INT106476

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Context Info
Confidence 0.60
First Reported 2002
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.32
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Syp)
Anatomy Link Frequency
synapse 4
spinal cord 2
brain 2
Syp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 147 99.64 Very High Very High Very High
Spinal cord 2 99.52 Very High Very High Very High
Eae 5 98.80 Very High Very High Very High
Hippocampus 20 97.92 Very High Very High Very High
Sciatic nerve 2 97.56 Very High Very High Very High
Peripheral nervous system 1 96.40 Very High Very High Very High
Spontaneous pain 1 94.88 High High
Hyperalgesia 1 94.16 High High
monoamine 2 93.60 High High
allodynia 1 93.48 High High
Disease Link Frequency Relevance Heat
Anxiety Disorder 76 99.72 Very High Very High Very High
Injury 9 97.96 Very High Very High Very High
Pain 1 94.40 High High
Hyperalgesia 3 94.16 High High
Neuropathic Pain 3 93.48 High High
Shock 21 90.08 High High
Nervous System Injury 1 88.80 High High
Cv Unclassified Under Development 48 85.12 High High
Middle Cerebral Artery Infarction 12 73.12 Quite High
Stroke 25 62.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altered synaptophysin expression in the rat spinal cord after chronic constriction injury of sciatic nerve.
Regulation (Altered) of Gene_expression (expression) of synaptophysin in spinal cord associated with eae, injury, sciatic nerve and spinal cord
1) Confidence 0.60 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 12429371 Disease Relevance 0.98 Pain Relevance 1.10
Here, we also determined the effects on the expression of two other genes (synaptophysin and growth-associated protein-43 (GAP-43)) known to be involved in synapse formation and axonal growth and likely regulated by BDNF.
Spec (determined) Regulation (effects) of Gene_expression (expression) of synaptophysin in synapse
2) Confidence 0.32 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17950272 Disease Relevance 0 Pain Relevance 0.50
In previous studies, an enriched environment (24), or motor balance and coordination training (7), influenced the expression of BDNF or synaptophysin in some brain regions, but not in other regions.
Regulation (influenced) of Gene_expression (expression) of synaptophysin in brain
3) Confidence 0.25 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967002 Disease Relevance 0.19 Pain Relevance 0.13
In our first series of experiments, we examined whether auditory fear conditioning regulates the expression of the postsynaptically-localized protein GluR1 [33] and the presynaptically-localized Ca2+-regulated synaptic vesicle proteins synapsin and synaptophysin [34] at LA synapses (Figure 1).
Spec (whether) Regulation (regulates) of Gene_expression (expression) of synaptophysin in synapses associated with anxiety disorder and amygdala
4) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.78 Pain Relevance 0.44
Our study reveals that the decrease in acute microglial activation was associated with a long term down regulation of synaptophysin and GAP-43 expression and to a significant decrease in BDNF production.
Regulation (regulation) of Gene_expression (expression) of synaptophysin
5) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779656 Disease Relevance 0.37 Pain Relevance 0.13

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