INT106482

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Context Info
Confidence 0.07
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 10.96
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Epo) aging (Epo) extracellular region (Epo)
Anatomy Link Frequency
kidney 4
neuronal 2
megakaryocytes 2
Epo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 12 97.16 Very High Very High Very High
cytokine 5 77.68 Quite High
Inflammation 7 77.28 Quite High
depression 1 53.92 Quite High
Inflammatory marker 3 26.12 Quite Low
palliative 1 25.00 Low Low
pruritus 1 25.00 Low Low
cva 12 5.00 Very Low Very Low Very Low
Migraine 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Erythremia 3 100.00 Very High Very High Very High
Sepsis 77 99.16 Very High Very High Very High
Chronic Renal Failure 162 98.70 Very High Very High Very High
Brain Injury 3 98.44 Very High Very High Very High
Anaemia 160 98.36 Very High Very High Very High
Erythrocytosis 1 97.80 Very High Very High Very High
Stroke 207 97.76 Very High Very High Very High
Cv Unclassified Under Development 10 97.16 Very High Very High Very High
Coagulation Disorder 3 94.52 High High
Renal Insufficiency 9 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tamion and colleagues [11] measured serial renin and erythropoietin levels over 48 hours in 50 septic shock patients.
Negative_regulation (measured) of Gene_expression (levels) of erythropoietin associated with sepsis
1) Confidence 0.07 Published 2005 Journal Crit Care Section Body Doc Link PMC1269453 Disease Relevance 1.64 Pain Relevance 0.10
Most patients with ESRD and even less severe kidney dysfunction are anemic because of a deficient erythropoietin production.
Negative_regulation (deficient) of Gene_expression (production) of erythropoietin in kidney associated with chronic renal failure
2) Confidence 0.04 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2973927 Disease Relevance 2.34 Pain Relevance 0.09
Polycythemia vera is distinguished from reactive erythrocytosis through erythropoietin independent growth of erythroid progenitors in vitro, suppressed levels of endogenous erythropoietin, possible overexpression of PRV-1 (polycythemia rubra vera-1), decreased c-Mpl expression on megakaryocytes, as well as overexpression of bcl-xL, and potentially aberrant activity of the Jak-Stat pathway.
Negative_regulation (decreased) of Gene_expression (expression) of erythropoietin in megakaryocytes associated with erythremia and erythrocytosis
3) Confidence 0.04 Published 2002 Journal Int. J. Hematol. Section Abstract Doc Link 12430925 Disease Relevance 1.75 Pain Relevance 0.04
Anemia is common among individuals with reduced kidney function, generally because of a decreased production of erythropoietin [25-31].
Negative_regulation (decreased) of Gene_expression (production) of erythropoietin in kidney associated with anaemia
4) Confidence 0.04 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2973927 Disease Relevance 2.90 Pain Relevance 0
When renal function is reduced, erythropoietin production is impaired, which could limit erythropoietin-induced neuronal protection against anemia-induced stroke.
Negative_regulation (impaired) of Gene_expression (production) of erythropoietin in neuronal associated with anaemia and stroke
5) Confidence 0.03 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2973927 Disease Relevance 2.34 Pain Relevance 0.08

General Comments

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