INT106483
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Mpl protein expression seems to peak around birth (Figure 2D-K) , but is maintained in the adult murine brain (Figure 3; Table 1). | |||||||||||||||
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The lack of Mpl expression in neuronal stem cells and the pattern of Mpl expression in the brain parenchyma support the concept that Thpo is critical for the selection of neurons to undergo apoptosis during a crucial period of neurogenesis. | |||||||||||||||
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RT-PCR analysis of Mpl expression | |||||||||||||||
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Mpl and Thpo mRNA expression in primary neurons, astrocytes, microglia, and neuronal stem cells | |||||||||||||||
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However, in the adult cerebellum, Mpl expression was located in Purkinje cells (Figure 3J).
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Amplification of Mpl transcripts showed the presence of Mpl expression not only in neurons, but also in cultured astrocytes (Figure 5A). | |||||||||||||||
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Biochemical and molecular studies of PV patients have revealed no mutations in the Epo receptor, but granulocytes from PV patients have increased transcripts for the urokinase plasminogen activator receptor family member PRV-1 [8], whereas PV platelets show decreased expression of c-Mpl, the receptor for thrombopoietin [9]. | |||||||||||||||
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Mpl and Thpo mRNA expression in primary neurons, astrocytes, microglia, and neuronal stem cells | |||||||||||||||
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Mpl and Thpo mRNA expression in primary neurons, astrocytes, microglia, and neuronal stem cells | |||||||||||||||
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Mpl and Thpo mRNA expression in primary neurons, astrocytes, microglia, and neuronal stem cells | |||||||||||||||
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ET is defined by thrombocytosis and is distinguished from reactive states by decreased megakaryocyte c-Mpl expression, and a propensity for thrombosis. | |||||||||||||||
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Polycythemia vera is distinguished from reactive erythrocytosis through erythropoietin independent growth of erythroid progenitors in vitro, suppressed levels of endogenous erythropoietin, possible overexpression of PRV-1 (polycythemia rubra vera-1), decreased c-Mpl expression on megakaryocytes, as well as overexpression of bcl-xL, and potentially aberrant activity of the Jak-Stat pathway. | |||||||||||||||
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We measured TPO and C-reactive protein (CRP), as well as monocyte-platelet binding and the platelet expression of P-selectin and of the TPO receptor, c-Mpl. | |||||||||||||||
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The UA patients also showed reduced platelet expression of the TPO receptor, c-Mpl. | |||||||||||||||
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General Comments
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