INT106484

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 6
Speculated 4
Reported most in Body
Documents 7
Total Number 87
Disease Relevance 20.20
Pain Relevance 16.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mpl)
Anatomy Link Frequency
brain 11
astrocytes 9
cerebellum 7
neurons 6
central nervous system 5
Mpl (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 8 100.00 Very High Very High Very High
Hippocampus 729 99.98 Very High Very High Very High
cerebral cortex 567 99.98 Very High Very High Very High
Central nervous system 1134 99.92 Very High Very High Very High
midbrain 324 99.48 Very High Very High Very High
medulla 648 99.44 Very High Very High Very High
Thalamus 405 98.72 Very High Very High Very High
Spinal cord 648 98.60 Very High Very High Very High
Pyramidal cell 81 94.00 High High
Inflammatory response 81 81.24 Quite High
Disease Link Frequency Relevance Heat
Erythremia 6 99.70 Very High Very High Very High
Hypoxia 324 99.64 Very High Very High Very High
Myelodysplastic Syndromes 130 99.48 Very High Very High Very High
Congenital Anomalies 668 99.40 Very High Very High Very High
Thrombosis 4 99.08 Very High Very High Very High
Thrombocytosis 4 98.60 Very High Very High Very High
Neurodegenerative Disease 324 98.56 Very High Very High Very High
Apoptosis 324 98.52 Very High Very High Very High
Myeloid Metaplasia 12 97.20 Very High Very High Very High
Erythrocytosis 72 96.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Widespread Mpl expression was found in the diencephalon (thalamus and hypothalamus) and mesencephalon (superior and inferior colliculus); other areas included the pons (metencephalon), medulla (myelencephalon), and the grey matter of the cervical spinal cord (Figure 2 D-G, Table 1).
Gene_expression (expression) of Mpl in diencephalon associated with medulla, thalamus and spinal cord
1) Confidence 0.78 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.40
Developmental changes in Mpl and Thpo mRNA expression throughout development
Gene_expression (expression) of Mpl
2) Confidence 0.78 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.04
However, from P4 onwards, Mpl is expressed in the hippocampus.
Gene_expression (expressed) of Mpl in hippocampus associated with hippocampus
3) Confidence 0.78 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.08 Pain Relevance 0.14
Mpl and Thpo mRNA expression in primary neurons, astrocytes, microglia, and neuronal stem cells
Gene_expression (expression) of Mpl in astrocytes
4) Confidence 0.78 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0
It becomes evident that the Mpl is developmentally regulated, since Mpl is not detectable on protein levels at the very early stages (E12 and E15) of brain development (Figure 2A-C).
Neg (not) Gene_expression (detectable) of Mpl in brain
5) Confidence 0.78 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.08 Pain Relevance 0.04
Amplification of Mpl transcripts showed the presence of Mpl expression not only in neurons, but also in cultured astrocytes (Figure 5A).
Gene_expression (expression) of Mpl in astrocytes
6) Confidence 0.78 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.05 Pain Relevance 0
However, in the adult cerebellum, Mpl expression was located in Purkinje cells (Figure 3J).


Gene_expression (expression) of Mpl in cerebellum
7) Confidence 0.78 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.04
Mpl expressing regions in the telencephalon included the cerebral cortex, the hippocampus and the mantle zone of the olfactory bulb (data not shown).
Gene_expression (expressing) of Mpl in hippocampus associated with hippocampus and cerebral cortex
8) Confidence 0.78 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.47
Expression pattern of Mpl in the developing brain
Gene_expression (Expression) of Mpl in brain
9) Confidence 0.78 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.15
To characterize the cells, which express Mpl in the brain, we performed double immunohistochemistry with antibodies directed against Mpl as well as with established markers for neurons and astrocytes.
Gene_expression (express) of Mpl in astrocytes
10) Confidence 0.78 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.42
During the neonatal period and in adulthood of mice, Mpl expression remains robust in the diencephalon, mesencephalon, myelencephalon and the grey matter of the spinal cord (Table 1).
Gene_expression (expression) of Mpl in spinal cord associated with spinal cord
11) Confidence 0.78 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.15
Similarly, Mpl-expression is maintained in most areas of the diencephalon, including thalamus and hypothalamus (Figures 3F-H, Table 1).
Gene_expression (expression) of Mpl in hypothalamus associated with thalamus
12) Confidence 0.78 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.44
RT-PCR analysis of Mpl expression
Gene_expression (expression) of Mpl
13) Confidence 0.78 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.04
To further elucidate the role of the Thpo/Mpl system in the brain, we analysed herein the expression pattern of the Mpl protein in the murine brain by immunohistochemistry.
Gene_expression (expression) of Mpl protein in brain
14) Confidence 0.78 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.08 Pain Relevance 0.03
The majority of Mpl-positive cells in the developing brain co-expressed the pan-neuronal marker NeuN with one exception: Mpl-expressing cells in the cerebellar white matter did not co-express NeuN (Figure 4A), indicating their possible glial origin.
Gene_expression (expressing) of Mpl in brain
15) Confidence 0.78 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.26
Mpl protein expression seems to peak around birth (Figure 2D-K) , but is maintained in the adult murine brain (Figure 3; Table 1).
Gene_expression (expression) of Mpl protein in brain
16) Confidence 0.78 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.07 Pain Relevance 0.04
Mpl expression peaks in some crucial brain areas at a period, when normal neurogenesis prunes.
Gene_expression (expression) of Mpl in brain associated with neurodegenerative disease
17) Confidence 0.78 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.52 Pain Relevance 0.04
Notably, the strongest variations of Mpl expression occur in the telencephalon and in the metencephalon: In the telencephalon, Mpl-positive cells are initially located in the cortical subventricular zone and in the caudal cortex (Figures 2H, I), but not in the developing white matter.
Gene_expression (expression) of Mpl in cortex
18) Confidence 0.78 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.20
From E18 onwards Mpl protein expression was detectable in the prosencephalon, midbrain, and rhombencephalon as well as in the spinal cord (Table 1).
Gene_expression (expression) of Mpl protein in rhombencephalon associated with midbrain and spinal cord
19) Confidence 0.78 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.36
Moreover, we performed double labelling with the Mpl antibody and the astrocyte marker GFAP to investigate Mpl expression in astrocytes under physiological conditions.
Spec (investigate) Gene_expression (expression) of Mpl in astrocytes
20) Confidence 0.78 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.10

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