INT106487

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Context Info
Confidence 0.02
First Reported 2002
Last Reported 2002
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.74
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD177, Mpl)
Anatomy Link Frequency
megakaryocytes 3
CD177 (Homo sapiens)
Mpl (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1 70.08 Quite High
palliative 1 25.00 Low Low
pruritus 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Erythremia 3 100.00 Very High Very High Very High
Erythrocytosis 1 97.30 Very High Very High Very High
Myelodysplastic Syndromes 3 90.72 High High
Thrombocytosis 2 89.36 High High
Myeloproliferative Disorder 3 87.96 High High
Myeloid Leukemia 2 81.00 Quite High
Thrombosis 1 79.52 Quite High
Myeloid Metaplasia 6 78.56 Quite High
Disease 4 71.56 Quite High
Fibrosis 1 70.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Polycythemia vera is distinguished from reactive erythrocytosis through erythropoietin independent growth of erythroid progenitors in vitro, suppressed levels of endogenous erythropoietin, possible overexpression of PRV-1 (polycythemia rubra vera-1), decreased c-Mpl expression on megakaryocytes, as well as overexpression of bcl-xL, and potentially aberrant activity of the Jak-Stat pathway.
Spec (1061) Gene_expression (overexpression) of polycythemia rubra vera-1 in megakaryocytes Negative_regulation (decreased) of Gene_expression (expression) of c-Mpl in megakaryocytes associated with erythremia and erythrocytosis
1) Confidence 0.02 Published 2002 Journal Int. J. Hematol. Section Abstract Doc Link 12430925 Disease Relevance 1.74 Pain Relevance 0.04

General Comments

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