INT106498

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Context Info
Confidence 0.08
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.41
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Lhcgr) endoplasmic reticulum (Lhcgr) cytoplasm (Lhcgr)
signal transducer activity (Lhcgr) extracellular space (Lhcgr) extracellular region (Lhcgr)
Anatomy Link Frequency
puncture 1
Lhcgr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 1 90.08 High High
agonist 4 52.48 Quite High
antagonist 4 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adrenocortical Hyperfunction 4 98.80 Very High Very High Very High
Targeted Disruption 6 78.88 Quite High
Hyperplasia 1 67.04 Quite High
Polycystic Ovary Syndrome 6 5.00 Very Low Very Low Very Low
Diabetes Mellitus 1 5.00 Very Low Very Low Very Low
Hyperandrogenism 1 5.00 Very Low Very Low Very Low
Hyperinsulinism 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Reprotox - General 3 1 5.00 Very Low Very Low Very Low
Anovulation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As expression of the LH receptor increases, the relative expression of PPAR?
Positive_regulation (increases) of LH receptor
1) Confidence 0.08 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2795759 Disease Relevance 0.08 Pain Relevance 0.03
Four studies were performed to test the hypothesis that gonadotrophic hormones, and particularly luteinizing hormone (LH) play a role in the pathogenesis of ferrets: (I) adrenal glands of ferrets with hyperadrenocorticism were studied immunohistochemically to detect LH-receptors (LH-R); (II) gonadotrophin-releasing hormone (GnRH) stimulation tests were performed in 10 neutered ferrets, with measurement of androstenedione, 17alpha-hydroxyprogesterone and cortisol as endpoints; (III) GnRH stimulation tests were performed in 15 ferrets of which 8 had hyperadrenocorticism, via puncture of the vena cava under anesthesia; and (IV) urinary corticoid/creatinine (C/C) ratios were measured at 2-week intervals for 1 year in the same ferrets as used in study II.
Positive_regulation (performed) of LH-R in puncture associated with anesthesia and adrenocortical hyperfunction
2) Confidence 0.04 Published 2002 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 12431804 Disease Relevance 0.33 Pain Relevance 0.09

General Comments

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