INT106504

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.32
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGDR2) signal transducer activity (PTGDR2)
Anatomy Link Frequency
lung 1
Th2 cells 1
basophils 1
mast cells 1
PTGDR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 37 100.00 Very High Very High Very High
Pain 3 95.00 High High
chemokine 23 93.96 High High
Central nervous system 3 92.92 High High
cytokine 91 78.56 Quite High
agonist 21 77.68 Quite High
cINOD 3 72.12 Quite High
Potency 2 49.28 Quite Low
adenocard 2 22.40 Low Low
Inflammation 96 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 12 99.98 Very High Very High Very High
Asthma 316 99.12 Very High Very High Very High
Pain 3 95.00 High High
INFLAMMATION 104 71.88 Quite High
Targeted Disruption 26 50.56 Quite High
Eosinophilia 19 5.00 Very Low Very Low Very Low
Disease 17 5.00 Very Low Very Low Very Low
Occupational Lung Diseases 15 5.00 Very Low Very Low Very Low
Rhinitis 11 5.00 Very Low Very Low Very Low
Hyperplasia 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In whole-cell saturation-binding assays, 1 and 2 both increase the number of [(3)H]prostaglandin D2 (PGD2)-recognizing CRTH2 sites and the affinity of PGD2 for CRTH2.
Positive_regulation (increase) of CRTH2
1) Confidence 0.49 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15870392 Disease Relevance 0.15 Pain Relevance 0.15
It is also actively produced by mast cells, basophils, and Th2 cells, acting as an allergic mediator through DP and CRTH2 receptors.
Positive_regulation (mediator) of CRTH2 in Th2 cells associated with hypersensitivity
2) Confidence 0.49 Published 2002 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 12432930 Disease Relevance 0.25 Pain Relevance 0.14
It is also actively produced by mast cells, basophils, and Th2 cells, acting as an allergic mediator through DP and CRTH2 receptors.
Positive_regulation (mediator) of CRTH2 in basophils associated with hypersensitivity
3) Confidence 0.17 Published 2002 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 12432930 Disease Relevance 0.25 Pain Relevance 0.14
It is also actively produced by mast cells, basophils, and Th2 cells, acting as an allergic mediator through DP and CRTH2 receptors.
Positive_regulation (mediator) of CRTH2 in mast cells associated with hypersensitivity
4) Confidence 0.17 Published 2002 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 12432930 Disease Relevance 0.25 Pain Relevance 0.14
CCR3, CCR4, CCR8, and CRTH2 non-peptide antagonists are involved in the recruitment and/or activation of Th2 cells in the lung and are now being evaluated for the treatment of bronchial asthma but so far, no clinical data for these compounds have been reported.
Neg (without) Positive_regulation (evaluated) of CRTH2 in lung associated with asthma and antagonist
5) Confidence 0.05 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.44 Pain Relevance 0.46

General Comments

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