INT106508

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Context Info
Confidence 0.20
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 12
Total Number 14
Disease Relevance 5.37
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptges) nucleus (Ptges) cytoplasm (Ptges)
Anatomy Link Frequency
muscle tissue 4
RAW 264 4
macrophage 2
peritoneal macrophages 2
Ptges (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 106 98.80 Very High Very High Very High
cINOD 16 98.36 Very High Very High Very High
IPN 3 97.08 Very High Very High Very High
Arthritis 5 96.20 Very High Very High Very High
cytokine 41 91.04 High High
Inflammatory response 15 91.04 High High
Inflammatory stimuli 11 81.28 Quite High
Pain 11 75.64 Quite High
chemokine 16 60.24 Quite High
COX-2 inhibitor 9 50.00 Quite Low
Disease Link Frequency Relevance Heat
Myositis 54 99.84 Very High Very High Very High
INFLAMMATION 142 98.80 Very High Very High Very High
Shock 1 98.12 Very High Very High Very High
Inflammatory Pain 3 97.08 Very High Very High Very High
Arthritis 5 96.20 Very High Very High Very High
Syndrome 1 96.08 Very High Very High Very High
Disease 25 95.48 Very High Very High Very High
Dermatomyositis 22 89.56 High High
Polymyositis 20 88.80 High High
Hypertension 17 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we examined the effects of liver X receptor (LXR) ligands on LPS-induced mPGES-1 expression in murine peritoneal macrophages.
Spec (examined) Positive_regulation (induced) of Gene_expression (expression) of mPGES-1 in peritoneal macrophages
1) Confidence 0.20 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17049841 Disease Relevance 0.56 Pain Relevance 0.28
The LXR ligands 22(R)-hydroxycholesterol (22R-HC) and T0901317 reduced LPS-induced expression of mPGES-1 mRNA and mPGES-1 protein as well as that of COX-2 protein.
Positive_regulation (induced) of Gene_expression (expression) of mPGES-1 mRNA
2) Confidence 0.20 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17049841 Disease Relevance 0.52 Pain Relevance 0.26
Angiotensin II infusion upregulated aortic expression of cyclooxygenase-2 and mPGES-1, increased aortic macrophage recruitment and vascular nitrotyrosine staining (which reflects local oxidative stress), and augmented urinary excretion of the isoprostane 8,12-iso-iPF(2alpha)-VI (which reflects lipid peroxidation in vivo) and the major metabolite of PGE(2) (PGE-M).
Positive_regulation (upregulated) of Gene_expression (expression) of mPGES-1 in macrophage
3) Confidence 0.17 Published 2008 Journal Circulation Section Body Doc Link 18285567 Disease Relevance 0.31 Pain Relevance 0
The LXR ligands 22(R)-hydroxycholesterol (22R-HC) and T0901317 reduced LPS-induced expression of mPGES-1 mRNA and mPGES-1 protein as well as that of COX-2 protein.
Positive_regulation (-) of Gene_expression (expression) of mPGES-1 mRNA
4) Confidence 0.14 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17049841 Disease Relevance 0.52 Pain Relevance 0.26
LPS stimulation induced the coordinated synthesis of COX-2 and mPGES-1 that resulted in an enhanced production of PGE(2) in RAW 264.7 macrophages.
Positive_regulation (induced) of Gene_expression (synthesis) of mPGES-1 in RAW 264
5) Confidence 0.08 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.41 Pain Relevance 0.16
Inhibition of Egr-1 expression reduced substantially LPS-mediated induction of COX-2 and mPGES-1 expression, resulting in a decrease in PGE(2) production.
Positive_regulation (induction) of Gene_expression (expression) of mPGES-1
6) Confidence 0.06 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.13 Pain Relevance 0.07
LPS stimulation induced the coordinated synthesis of COX-2 and mPGES-1 that resulted in an enhanced production of PGE(2) in RAW 264.7 macrophages.
Positive_regulation (resulted) of Gene_expression (synthesis) of mPGES-1 in RAW 264
7) Confidence 0.06 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.41 Pain Relevance 0.16
The coordinate increased expression of COX-2 and mPGES-1 is reversed by glucocorticoids.
Positive_regulation (increased) of Gene_expression (expression) of mPGES-1
8) Confidence 0.05 Published 2007 Journal Pharmacol. Rev. Section Abstract Doc Link 17878511 Disease Relevance 0.43 Pain Relevance 0.11
mRNA expression of mPGES-1 is increased in COX-2-/- mice after LPS
Positive_regulation (increased) of Gene_expression (expression) of mPGES-1
9) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0 Pain Relevance 0.15
mRNA expression of mPGES-1 is increased in COX-2-/- mice after LPS
Positive_regulation (after) of Gene_expression (expression) of mPGES-1
10) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0 Pain Relevance 0.15
These findings are consistent with increased mPGES expression
Positive_regulation (increased) of Gene_expression (expression) of mPGES
11) Confidence 0.03 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0.38 Pain Relevance 0.05
Moreover, we have shown for the first time that conventional immunosuppressive treatment led to a significant downregulation of COX-2 in myositis muscle tissue, while the expression of mPGES-1 and COX-1 remained unchanged.
Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (expression) of mPGES-1 in muscle tissue associated with myositis
12) Confidence 0.02 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2582339 Disease Relevance 0.66 Pain Relevance 0.10
In addition, mPGES-1 expression was enhanced in myositis muscle tissue, as an increased number of positively stained scattered mononuclear cells and as positively stained cells within inflammatory infiltrates compared to low constitutive expression in healthy muscle tissue.
Positive_regulation (enhanced) of Gene_expression (expression) of mPGES-1 in muscle tissue associated with inflammation and myositis
13) Confidence 0.02 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2582339 Disease Relevance 0.85 Pain Relevance 0.26
Membrane-associated PGES (mPGES), the expression of which is stimulus-inducible and is downregulated by anti-inflammatory glucocorticoids, is a perinuclear protein belonging to the microsomal glutathione S-transferase (GST) family.
Positive_regulation (inducible) of Gene_expression (expression) of mPGES associated with inflammation
14) Confidence 0.01 Published 2002 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 12432931 Disease Relevance 0.20 Pain Relevance 0.05

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