INT106509

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Context Info
Confidence 0.17
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.95
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptges) nucleus (Ptges) cytoplasm (Ptges)
Anatomy Link Frequency
RAW 264 2
Ptges (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 9 99.64 Very High Very High Very High
licofelone 8 95.92 Very High Very High Very High
IPN 2 92.12 High High
Arthritis 2 91.24 High High
Inflammatory response 2 86.08 High High
Angina 1 84.88 Quite High
Inflammatory stimuli 2 76.32 Quite High
Pain 2 73.52 Quite High
Osteoarthritis 1 42.16 Quite Low
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 10 99.64 Very High Very High Very High
Shock 1 98.12 Very High Very High Very High
Inflammatory Pain 2 92.12 High High
Arthritis 2 91.24 High High
Disease 3 90.52 High High
Trepenoma Infection 1 85.28 High High
Cv General 3 Under Development 1 84.88 Quite High
Pain 1 73.52 Quite High
Fever 1 73.04 Quite High
Appetite Loss 1 72.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The LXR ligands 22(R)-hydroxycholesterol (22R-HC) and T0901317 reduced LPS-induced expression of mPGES-1 mRNA and mPGES-1 protein as well as that of COX-2 protein.
Negative_regulation (reduced) of Gene_expression (expression) of mPGES-1 mRNA
1) Confidence 0.17 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17049841 Disease Relevance 0.53 Pain Relevance 0.26
The LXR ligands 22(R)-hydroxycholesterol (22R-HC) and T0901317 reduced LPS-induced expression of mPGES-1 mRNA and mPGES-1 protein as well as that of COX-2 protein.
Negative_regulation (reduced) of Gene_expression (expression) of mPGES-1 protein
2) Confidence 0.12 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17049841 Disease Relevance 0.53 Pain Relevance 0.26
The coordinate increased expression of COX-2 and mPGES-1 is reversed by glucocorticoids.
Negative_regulation (reversed) of Gene_expression (expression) of mPGES-1
3) Confidence 0.04 Published 2007 Journal Pharmacol. Rev. Section Abstract Doc Link 17878511 Disease Relevance 0.44 Pain Relevance 0.11
We conclude that licofelone suppresses inflammatory PGE(2) formation preferentially by inhibiting mPGES-1 at concentrations that do not affect COX-2, implying an attractive and thus far unique molecular pharmacological dynamics as inhibitor of COX-1, the 5-lipoxygenase pathway, and of mPGES-1.
Negative_regulation (inhibitor) of Gene_expression (pathway) of mPGES-1 associated with inflammation and licofelone
4) Confidence 0.02 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18550688 Disease Relevance 0.10 Pain Relevance 0.48
Membrane-associated PGES (mPGES), the expression of which is stimulus-inducible and is downregulated by anti-inflammatory glucocorticoids, is a perinuclear protein belonging to the microsomal glutathione S-transferase (GST) family.
Negative_regulation (downregulated) of Gene_expression (expression) of mPGES associated with inflammation
5) Confidence 0.01 Published 2002 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 12432931 Disease Relevance 0.20 Pain Relevance 0.05
Additionally, BSG inhibited mPGES protein expression and COX-2 activity in activated RAW 264.7 cells.
Negative_regulation (inhibited) of Gene_expression (expression) of mPGES protein in RAW 264
6) Confidence 0.00 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 14985087 Disease Relevance 0.17 Pain Relevance 0.08

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