INT10651

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Context Info
Confidence 0.67
First Reported 1992
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.16
Pain Relevance 2.22

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endoplasmic reticulum (Ugt2b7) molecular_function (Ugt2b7) cellular_component (Ugt2b7)
biological_process (Ugt2b7)
Anatomy Link Frequency
liver 2
2B7 1
Ugt2b7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 30 100.00 Very High Very High Very High
Patient controlled alalgesia 1 98.52 Very High Very High Very High
dexamethasone 1 77.44 Quite High
Angina 1 55.68 Quite High
Bile 1 55.52 Quite High
cINOD 1 52.80 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 1 57.04 Quite High
Cv General 3 Under Development 1 55.68 Quite High
INFLAMMATION 1 51.36 Quite High
Heart Disease 1 25.00 Low Low
Disorders Of Creatine Metabolism 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Within the selective induction of phase II enzymes following treatment with dipyridyls or N-heterocyclic analogs of phenanthrene, strong correlations (r > or = 0.70) are observed between the increase of microsomal epoxide hydrolase (mEH) activity and UDP-glucuronosyltransferase (UGT) activities towards 4-nitrophenol, 1-naphthol and morphine.
Positive_regulation (increase) of UGT associated with morphine
1) Confidence 0.67 Published 1996 Journal Toxicol. Lett. Section Abstract Doc Link 8619256 Disease Relevance 0 Pain Relevance 0.14
In vitro NADPH-mediated lipid peroxidation significantly increased the activity of both the high and low affinity morphine-UGT isoenzymes.
Positive_regulation (increased) of UGT associated with morphine
2) Confidence 0.45 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1510722 Disease Relevance 0 Pain Relevance 0.64
V79 (Chinese hamster lung fibroblast) cell lines expressing a functional recombinant phenobarbital-inducible rat liver UDP-glucuronosyltransferase (UGT), i.e., UGT2B1, were established.
Positive_regulation (inducible) of UGT in liver
3) Confidence 0.45 Published 1994 Journal Mol. Pharmacol. Section Abstract Doc Link 8302279 Disease Relevance 0.05 Pain Relevance 0.16
Although the morphine UGT activity in the liver of Gunn rats was increased by phenobarbital (PB) treatment, this was significantly less than that in the liver of PB-treated Wistar rats.
Positive_regulation (increased) of UGT in liver associated with morphine
4) Confidence 0.45 Published 1997 Journal Drug Metab. Dispos. Section Abstract Doc Link 9029046 Disease Relevance 0 Pain Relevance 0.61
In our previous study it was observed that the frequencies of UGT1A1*6, UGT2B7*3 and CYP2D6*10 in patients who have a low level ability of glucuronidation were significantly higher than those in patients with a high level of ability of glucuronidation.
Positive_regulation (frequencies) of UGT2B7
5) Confidence 0.36 Published 2007 Journal Biol. Pharm. Bull. Section Abstract Doc Link 17329852 Disease Relevance 0.11 Pain Relevance 0.06
We investigated the variation in the uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7) gene in patients receiving patient-controlled analgesia with morphine.
Spec (investigated) Positive_regulation (variation) of uridine diphosphate-glucuronosyltransferase 2B7 in 2B7 associated with patient controlled alalgesia and morphine
6) Confidence 0.13 Published 2003 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 12811366 Disease Relevance 0 Pain Relevance 0.62

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