INT106510

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 70
Total Number 73
Disease Relevance 36.18
Pain Relevance 9.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptges) nucleus (Ptges) cytoplasm (Ptges)
Anatomy Link Frequency
muscle tissue 9
macrophages 5
kidney 5
lung 3
muscle 2
Ptges (Mus musculus)
Pain Link Frequency Relevance Heat
licofelone 16 99.60 Very High Very High Very High
Neuropathic pain 11 99.36 Very High Very High Very High
cINOD 150 98.36 Very High Very High Very High
Inflammatory stimuli 34 98.32 Very High Very High Very High
rheumatoid arthritis 33 98.28 Very High Very High Very High
Thermal hyperalgesia 2 98.00 Very High Very High Very High
Inflammation 762 97.56 Very High Very High Very High
allodynia 2 97.00 Very High Very High Very High
IPN 7 96.80 Very High Very High Very High
Arthritis 43 95.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Myositis 729 99.96 Very High Very High Very High
Hypertension 425 99.76 Very High Very High Very High
Multiple Sclerosis 64 99.42 Very High Very High Very High
Neuropathic Pain 13 99.36 Very High Very High Very High
Targeted Disruption 332 99.24 Very High Very High Very High
Dermatomyositis 297 98.68 Very High Very High Very High
Polymyositis 270 98.60 Very High Very High Very High
INFLAMMATION 847 98.32 Very High Very High Very High
Rheumatoid Arthritis 34 98.28 Very High Very High Very High
Shock 2 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is also likely that the activity of PGE synthase (PGES), which produces PGE2 from PGH2, may increase in lungs of CFTR -/- mice.
Gene_expression (produces) of PGES in lungs
1) Confidence 0.75 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.33 Pain Relevance 0.16
These results demonstrate that PGE2 produced by mPGES-1 is involved in neuropathic pain.
Gene_expression (produced) of mPGES-1 associated with neuropathic pain
2) Confidence 0.59 Published 2004 Journal Neuroreport Section Abstract Doc Link 15194860 Disease Relevance 0.96 Pain Relevance 0.74
PGE2 is produced from arachidonic acid via PGH2 by at least three PGE synthases (PGES), cytosolic PGES (cPGES), and membrane-associated PGES (mPGES)-1 and -2.
Gene_expression (produced) of PGES
3) Confidence 0.51 Published 2004 Journal Neuroreport Section Abstract Doc Link 15194860 Disease Relevance 0.83 Pain Relevance 0.69
Angiotensin II infusion upregulated aortic expression of cyclooxygenase-2 and mPGES-1, increased aortic macrophage recruitment and vascular nitrotyrosine staining (which reflects local oxidative stress), and augmented urinary excretion of the isoprostane 8,12-iso-iPF(2alpha)-VI (which reflects lipid peroxidation in vivo) and the major metabolite of PGE(2) (PGE-M).
Gene_expression (expression) of mPGES-1 in macrophage
4) Confidence 0.26 Published 2008 Journal Circulation Section Body Doc Link 18285567 Disease Relevance 0.31 Pain Relevance 0
Here, we examined the effects of liver X receptor (LXR) ligands on LPS-induced mPGES-1 expression in murine peritoneal macrophages.
Gene_expression (expression) of mPGES-1 in peritoneal macrophages
5) Confidence 0.23 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17049841 Disease Relevance 0.55 Pain Relevance 0.28
The LXR ligands 22(R)-hydroxycholesterol (22R-HC) and T0901317 reduced LPS-induced expression of mPGES-1 mRNA and mPGES-1 protein as well as that of COX-2 protein.
Gene_expression (expression) of mPGES-1 mRNA
6) Confidence 0.23 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17049841 Disease Relevance 0.52 Pain Relevance 0.26
The LXR ligands 22(R)-hydroxycholesterol (22R-HC) and T0901317 reduced LPS-induced expression of mPGES-1 mRNA and mPGES-1 protein as well as that of COX-2 protein.
Gene_expression (expression) of mPGES-1 protein
7) Confidence 0.23 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17049841 Disease Relevance 0.52 Pain Relevance 0.26
However, LXR ligands did not influence the expression of microsomal PGES-2 (mPGES-2) or cytosolic PGES (cPGES) protein.
Gene_expression (expression) of cytosolic PGES
8) Confidence 0.15 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17049841 Disease Relevance 0.49 Pain Relevance 0.25
Cytosolic PGES (cPGES) is constitutively expressed in a wide variety of mammalian cell lines and tissues and is not responsive to stimulation with bacterial lipopolysaccharide (LPS) [7].
Gene_expression (expressed) of PGES
9) Confidence 0.11 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.11 Pain Relevance 0.08
EAE is less severe in mice that lack the microsomal PGE synthase 1 (MPGES-1) gene that codes for the enzyme that synthesizes PGE2 from COX-derived PGH2 [40].
Gene_expression (synthesizes) of MPGES-1 associated with multiple sclerosis
10) Confidence 0.11 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2873241 Disease Relevance 1.13 Pain Relevance 0.33
EAE is less severe in mice that lack the microsomal PGE synthase 1 (MPGES-1) gene that codes for the enzyme that synthesizes PGE2 from COX-derived PGH2 [40].
Neg (lack) Gene_expression (lack) of MPGES-1 associated with multiple sclerosis
11) Confidence 0.11 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2873241 Disease Relevance 1.23 Pain Relevance 0.35
Here, we have investigated the mechanisms involved in the regulation of COX-2 and mPGES-1 expressions in murine macrophages upon bacterial lipopolysaccharide (LPS) treatment.
Gene_expression (expressions) of mPGES-1 in macrophages
12) Confidence 0.09 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.43 Pain Relevance 0.17
Inhibition of Egr-1 expression reduced substantially LPS-mediated induction of COX-2 and mPGES-1 expression, resulting in a decrease in PGE(2) production.
Gene_expression (expression) of mPGES-1
13) Confidence 0.09 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.12 Pain Relevance 0.07
LPS stimulation induced the coordinated synthesis of COX-2 and mPGES-1 that resulted in an enhanced production of PGE(2) in RAW 264.7 macrophages.
Gene_expression (synthesis) of mPGES-1 in RAW 264
14) Confidence 0.09 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.41 Pain Relevance 0.16
mRNA expression of mPGES-1 is increased in COX-2-/- mice after LPS
Gene_expression (expression) of mPGES-1
15) Confidence 0.06 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0 Pain Relevance 0.15
No mPGES-1 expression was present
Gene_expression (expression) of mPGES
16) Confidence 0.06 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0 Pain Relevance 0
mPGES-2 is constitutively expressed
Gene_expression (expressed) of mPGES
17) Confidence 0.06 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0.20 Pain Relevance 0.15
The coordinate increased expression of COX-2 and mPGES-1 is reversed by glucocorticoids.
Gene_expression (expression) of mPGES-1
18) Confidence 0.05 Published 2007 Journal Pharmacol. Rev. Section Abstract Doc Link 17878511 Disease Relevance 0.43 Pain Relevance 0.11
cardiac distribution and cellular localization of mPGES-1, mPGES-2,
Gene_expression (distribution) of mPGES
19) Confidence 0.05 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0.31 Pain Relevance 0.05
L of primary anti-COX-1 (1:200), COX-2 (1:20), mPGES-1 (1:750), or mPGES-2 (1:1000) antibody (Cayman Chemical, Ann Arbor, MI) diluted with reagent diluent (Ventana Medical Systems) at room
Gene_expression (1:200) of mPGES
20) Confidence 0.05 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0 Pain Relevance 0

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