INT106511

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Context Info
Confidence 0.01
First Reported 2002
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.70
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cpox, Ptges3) unfolded protein binding (Ptges3) isomerase activity (Ptges3)
mitochondrion (Cpox) protein complex (Ptges3) cell proliferation (Ptges3)
Cpox (Rattus norvegicus)
Ptges3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 1 95.68 Very High Very High Very High
Inflammation 25 95.04 Very High Very High Very High
cytokine 3 91.08 High High
agonist 21 50.00 Quite Low
Inflammatory stimuli 2 28.28 Quite Low
Pain 3 25.00 Low Low
COX2 1 25.00 Low Low
cINOD 2 21.24 Low Low
Potency 16 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 29 95.04 Very High Very High Very High
Shock 2 86.60 High High
Cancer 1 10.96 Low Low
Necrosis 1 10.40 Low Low
Arthritis 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As mentioned above, PGES-1 isoforms display distinct functional coupling with upstream COX in cells; cPGES-1 is predominantly coupled with constitutive COX-1, thereby contributing to basal PG synthesis, whereas mPGES-1 is preferentially linked with inducible COX-2 and contributes to stimulated PG synthesis [7].
COX Binding (coupled) of cPGES-1
1) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.52 Pain Relevance 0.31
These two PGESs display distinct functional coupling with upstream COXs in cells; cPGES is predominantly coupled with the constitutive COX-1, whereas mPGES is preferentially linked with the inducible COX-2.
COX Binding (coupled) of cPGES
2) Confidence 0.00 Published 2002 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 12432931 Disease Relevance 0.18 Pain Relevance 0.05

General Comments

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