INT106522

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 65
Total Number 65
Disease Relevance 34.44
Pain Relevance 7.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
muscle 6
aortas 4
cortex 4
C16 4
myoblast 4
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 214 100.00 Very High Very High Very High
agonist 147 99.76 Very High Very High Very High
opioid receptor 88 99.68 Very High Very High Very High
Clonidine 59 99.66 Very High Very High Very High
Calcium channel 35 99.58 Very High Very High Very High
ischemia 44 99.54 Very High Very High Very High
antagonist 30 99.04 Very High Very High Very High
rheumatoid arthritis 10 98.68 Very High Very High Very High
Hippocampus 19 97.84 Very High Very High Very High
cytokine 124 97.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 419 100.00 Very High Very High Very High
Obesity 704 99.98 Very High Very High Very High
Diabetes Mellitus 211 99.84 Very High Very High Very High
Targeted Disruption 548 99.80 Very High Very High Very High
Apoptosis 342 99.66 Very High Very High Very High
Cv Unclassified Under Development 42 99.54 Very High Very High Very High
Lung Cancer 22 99.36 Very High Very High Very High
Aging 379 99.26 Very High Very High Very High
Toxicity 35 99.08 Very High Very High Very High
Injury 101 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As2O3 inhibits phosphorylation of Akt, mTOR (mammalian target of rapamycin), and p70s6k
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of Akt
1) Confidence 0.58 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0 Pain Relevance 0
M) significantly decreased the phosphorylation of Akt (Figure 5B) and its downstream targets, mTOR and p70s6k proteins, during myogenic differentiation in a dose-dependent manner Figure 6B).
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of Akt
2) Confidence 0.58 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0 Pain Relevance 0
In the present study, we found that a submicromolar concentration of As2O3 significantly and dose-dependently decreased phosphorylation of Akt protein and its downstream targets, mTOR and p70s6k, during myogenic differentiation.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of Akt
3) Confidence 0.58 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.50 Pain Relevance 0.03
Ethanol-induced AKT phosphorylation was blocked by the opioid receptor antagonist naltrexone but unaffected by blockade of dopamine D2 receptors via sulpiride.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of AKT associated with dopamine, antagonist and opioid receptor
4) Confidence 0.57 Published 2010 Journal Addict Biol Section Abstract Doc Link 20456289 Disease Relevance 0 Pain Relevance 0.32
Interestingly, downregulation of phosphorylated PKB/Akt levels by wartmannin resulted in apoptosis of synoviocytes and macrophages in rheumatoid arthritis [33].
Negative_regulation (downregulation) of Phosphorylation (phosphorylated) of PKB/Akt in macrophages associated with rheumatoid arthritis and apoptosis
5) Confidence 0.57 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526584 Disease Relevance 1.26 Pain Relevance 0.34
The phosphorylation level of Akt (Thr308) was also decreased in the cortex of DGK?
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of Akt in cortex
6) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.67 Pain Relevance 0.08
KO mice are partly caused by the reduced phosphorylation levels of Akt and GSK3?.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of Akt associated with targeted disruption
7) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.37 Pain Relevance 0.03
Celecoxib, in a dose- and time-dependent manner, induced MM cell apoptosis, which involved decreased Akt phosphorylation, loss of Bcl-2 and Survivin protein expression and caspase-3 activation.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of Akt associated with lung cancer and apoptosis
8) Confidence 0.47 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14961568 Disease Relevance 1.45 Pain Relevance 0.22
Evodiamine treatment also reduced insulin-stimulated phosphorylation of Akt, a crucial regulator of adipocyte differentiation; and the reduction of phosphorylated-Akt and augmentation of phosphorylated ERK were reversed by blockade of the MAPK kinase/MAPK signaling pathway, restoring adipogenesis in the cultures.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of Akt in adipocyte
9) Confidence 0.45 Published 2008 Journal Endocrinology Section Abstract Doc Link 17884939 Disease Relevance 0.39 Pain Relevance 0.16
Furthermore, we observed that the Akt phosphorylation induced by MES was suppressed in the presence of PI3K inhibitors, LY294002 and wortmannin (Fig. 8F; pAkt).
Negative_regulation (suppressed) of Phosphorylation (phosphorylation) of Akt
10) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.19 Pain Relevance 0
M methylarsonous acid inhibited insulin-dependent phosphorylation of Akt on both Ser473 and Thr308 residues in 3T3-L1 adipocytes.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of Akt in 3T3-L1 associated with obesity
11) Confidence 0.43 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.39 Pain Relevance 0
Moreover, the increase in Akt phosphorylation observed 3 days after glycerol injection in the soleus muscles of control animals was markedly suppressed in animals treated with As2O3.
Negative_regulation (suppressed) of Phosphorylation (phosphorylation) of Akt in muscles
12) Confidence 0.43 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.71 Pain Relevance 0.12
In diabetic males (versus both control males and diabetic females): a) the clonidine- and insulin-induced endothelium-dependent aortic relaxations were impaired, but the acetylcholine (ACh)-induced and sodium nitroprusside (SNP)-induced aortic relaxations were not, b) the norepinephrine (NE)-induced aortic contractile response was enhanced, c) systemic blood pressure was elevated, and d) the clonidine-stimulated Ser-473 phosphorylation of Akt in the aorta was decreased.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of Akt in aorta associated with diabetes mellitus and clonidine
13) Confidence 0.43 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19721331 Disease Relevance 0.84 Pain Relevance 0.27
Furthermore, phosphorylated Akt was also reduced.
Negative_regulation (reduced) of Phosphorylation (phosphorylated) of Akt
14) Confidence 0.41 Published 2006 Journal Nat. Neurosci. Section Abstract Doc Link 17099708 Disease Relevance 0.16 Pain Relevance 0.13
Of note, these authors detected a decrease in PKB/Akt phosphorylation on Ser473 with no apparent change in PKB/Akt expression in kidney cortex of Irs2-/- mice (Fig. 6A, C[24]).
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of PKB/Akt in kidney cortex
15) Confidence 0.40 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2910663 Disease Relevance 0.13 Pain Relevance 0
The expression levels of both total Akt protein and clonidine-induced Ser-473-phosphorylated Akt were significantly decreased in diabetic aortas, while chronic simvastatin administration improved these decreased levels.
Negative_regulation (decreased) of Phosphorylation (phosphorylated) of Akt in aortas associated with diabetes mellitus and clonidine
16) Confidence 0.38 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18391484 Disease Relevance 0.96 Pain Relevance 0.36
The Akt (Ser473) phosphorylation was suppressed by As2O3 during myoblast differentiation.
Negative_regulation (suppressed) of Phosphorylation (phosphorylation) of Akt in myoblast
17) Confidence 0.37 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.56 Pain Relevance 0.07
Therefore, we checked Akt (Ser473) phosphorylation during myoblast differentiation.
Negative_regulation (checked) of Phosphorylation (phosphorylation) of Akt in myoblast
18) Confidence 0.37 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0 Pain Relevance 0
The two agonists stimulated Akt phosphorylation and the effect was also abolished by beta-FNA and by LY294002.
Negative_regulation (abolished) of Phosphorylation (phosphorylation) of Akt associated with agonist
19) Confidence 0.37 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12646285 Disease Relevance 0.40 Pain Relevance 0.64
KO mice, we assessed the phosophorylation levels of Akt and GSK3?
Negative_regulation (assessed) of Phosphorylation (phosophorylation) of Akt associated with targeted disruption
20) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 1.28 Pain Relevance 0.20

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