INT106523

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.10
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) nucleus (Jun) DNA binding (Jun)
transcription factor binding (Jun)
Anatomy Link Frequency
T cells 4
liver 2
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 9 96.88 Very High Very High Very High
Eae 1 94.92 High High
COX-2 inhibitor 3 88.16 High High
Inflammation 214 87.56 High High
cytokine 192 83.76 Quite High
rheumatoid arthritis 2 75.16 Quite High
cINOD 3 67.32 Quite High
Inflammatory response 20 52.56 Quite High
Paracetamol 3 41.60 Quite Low
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Obesity 130 96.84 Very High Very High Very High
Insulin Resistance 36 90.32 High High
Eosinophilia 19 88.92 High High
INFLAMMATION 236 87.56 High High
Apoptosis 50 84.88 Quite High
Stress 6 81.44 Quite High
Targeted Disruption 37 76.40 Quite High
Hepatocellular Cancer 48 75.44 Quite High
Rheumatoid Arthritis 2 75.16 Quite High
Cancer 72 74.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In JB6, Cox-2(-/-), or wild-type Cox-2(+/+) cells, both NS-398 and piroxicam inhibited UVB-induced phosphorylation of c-Jun NH(2)-terminal kinases, the kinases that activate the AP-1/c-Jun complex.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of c-Jun
1) Confidence 0.45 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12433932 Disease Relevance 0.14 Pain Relevance 0.19
Activated JNKs phosphorylate c-Jun, JunD, ATF, and other transcriptional factors, which are involved in the formation and activation of the AP-1 complex [43].
Positive_regulation (Activated) of Phosphorylation (phosphorylate) of Jun
2) Confidence 0.30 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.78 Pain Relevance 0.07
This analysis revealed, that basal JNK activity, as assessed by phosphorylation of c-Jun, was significantly reduced in skeletal muscle and exhibited a trend towards reduction in liver of obese IR?
Positive_regulation (assessed) of Phosphorylation (phosphorylation) of c-Jun in liver associated with obesity
3) Confidence 0.22 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.93 Pain Relevance 0.25
PTPH1 overexpression in Jurkat T cells reduces indirectly the TCR-induced serine phosphorylation of Mek, Erk, Jnk and AP-1 leading to a decreased IL-2 gene activation [13].
Positive_regulation (-) of Phosphorylation (phosphorylation) of AP-1 in T cells
4) Confidence 0.16 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.22 Pain Relevance 0.04
PTPH1 overexpression in Jurkat T cells reduces indirectly the TCR-induced serine phosphorylation of Mek, Erk, Jnk and AP-1 leading to a decreased IL-2 gene activation [13].
Positive_regulation (induced) of Phosphorylation (phosphorylation) of AP-1 in T cells
5) Confidence 0.11 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.22 Pain Relevance 0.04
Additionally, ST2L is able to activate the transcription factor AP-1; increase phosphorylation of c-Jun, and activate the MAP kinases c-Jun N-terminal kinase (JNK), p42/p44 and p38.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of c-Jun
6) Confidence 0.10 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.14 Pain Relevance 0.12
-catenin and on the other hand, in the inhibition of c-jun phosphorylation leading to an increase in the DNA binding activity of AP-1.
Positive_regulation (leading) of Phosphorylation (phosphorylation) of c-jun
7) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.67 Pain Relevance 0.05

General Comments

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