INT106525
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
In this immunohistochemical study we have monitored phosphorylated Akt (p-Akt) levels in adult mouse DRGs and spinal cord following unilateral peripheral sciatic nerve transection (axotomy) or carrageenan-induced inflammation. | |||||||||||||||
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In this immunohistochemical study we have monitored phosphorylated Akt (p-Akt) levels in adult mouse DRGs and spinal cord following unilateral peripheral sciatic nerve transection (axotomy) or carrageenan-induced inflammation. | |||||||||||||||
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These results strongly suggest that simvastatin improves the endothelial dysfunction seen in type 2 diabetic mice via increases in Akt and Akt phosphorylation. | |||||||||||||||
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These results strongly suggest that simvastatin improves the endothelial dysfunction seen in type 2 diabetic mice via increases in Akt and Akt phosphorylation. | |||||||||||||||
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Dexamethasone treatment prevented the decline of mitochondrial potential caused by bupivacaine and increased the levels of Akt phosphorylation. | |||||||||||||||
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As2O3 inhibits phosphorylation of Akt, mTOR (mammalian target of rapamycin), and p70s6k | |||||||||||||||
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M methylarsonous acid inhibited insulin-dependent phosphorylation of Akt on both Ser473 and Thr308 residues in 3T3-L1 adipocytes. | |||||||||||||||
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In the present study, we found that a submicromolar concentration of As2O3 significantly and dose-dependently decreased phosphorylation of Akt protein and its downstream targets, mTOR and p70s6k, during myogenic differentiation. | |||||||||||||||
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Therefore, we investigated the effects of As2O3 on the phosphorylation of Akt and its downstream signals, mTOR and p70s6k, during myogenic differentiation. | |||||||||||||||
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M) significantly decreased the phosphorylation of Akt (Figure 5B) and its downstream targets, mTOR and p70s6k proteins, during myogenic differentiation in a dose-dependent manner Figure 6B). | |||||||||||||||
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As shown in Figure 5B, Akt protein phosphorylation was gradually activated during myogenic differentiation. | |||||||||||||||
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We observed an increase of myogenin expression and Akt phosphorylation in the soleus muscles on day 3 after glycerol injection, but it was suppressed in As2O3-treated mice compared with control mice (Figure 8). | |||||||||||||||
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Here we report that an acute ethanol challenge induces a robust phosphorylation of two key signal transduction kinases, AKT and DARPP-32, in the striatum of mice. | |||||||||||||||
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Ethanol-induced AKT phosphorylation was blocked by the opioid receptor antagonist naltrexone but unaffected by blockade of dopamine D2 receptors via sulpiride. | |||||||||||||||
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In contrast, we have not observed any modulation of the phosphorylation of TrkB Shc binding site, phosphorylation of mitogen-activated protein kinase or AKT by antidepressants. | |||||||||||||||
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Interestingly, downregulation of phosphorylated PKB/Akt levels by wartmannin resulted in apoptosis of synoviocytes and macrophages in rheumatoid arthritis [33]. | |||||||||||||||
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Arvanil blocks the G1/S phase transition of the cell cycle in stimulated peripheral blood mononuclear cells, inducing activation of p21waf-1/cip-1 and phosphorylation of Akt/PKB. | |||||||||||||||
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We performed Western blot analysis of the total protein lysate from the tissues of mouse PIN lesions to measure the level of expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, BclII, AKT (total and phosphorylated Ser473), p53, cyclin-dependent kinase inhibitor p21WAF1/CIP1, p27, BAX, and caspase-3 to demonstrate the COX-2-independent mechanism involved in the inhibition of PIN lesions of the dorsolateral prostate by both celecoxib and exisulind. | |||||||||||||||
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Arvanil blocks the G1/S phase transition of the cell cycle in stimulated peripheral blood mononuclear cells, inducing activation of p21waf-1/cip-1 and phosphorylation of Akt/PKB. | |||||||||||||||
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Vasudevan reported that the tumor suppressor PTEN, which functions as a negative regulator of the phosphorylated Akt-mediated cell survival pathway in cholesteatoma, is downregulated by activated NF-? | |||||||||||||||
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