INT10654

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Context Info
Confidence 0.57
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 31
Total Number 31
Disease Relevance 12.24
Pain Relevance 11.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (SGSM3) cell cycle (SGSM3) cytoplasm (SGSM3)
Anatomy Link Frequency
blood 3
SVR 1
brain 1
astrocyte 1
skin 1
SGSM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 175 99.82 Very High Very High Very High
rheumatoid arthritis 1 99.74 Very High Very High Very High
Opioid 29 99.68 Very High Very High Very High
cINOD 11 99.50 Very High Very High Very High
antagonist 6 99.40 Very High Very High Very High
anesthesia 41 99.30 Very High Very High Very High
Paracetamol 14 99.04 Very High Very High Very High
epidural 10 98.98 Very High Very High Very High
isoflurane 8 98.96 Very High Very High Very High
narcan 2 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 8 100.00 Very High Very High Very High
Cv General 3 Under Development 172 99.82 Very High Very High Very High
Rheumatoid Arthritis 1 99.74 Very High Very High Very High
INFLAMMATION 8 99.38 Very High Very High Very High
Brain Injury 36 99.24 Very High Very High Very High
Nociception 1 98.70 Very High Very High Very High
Cough 11 98.68 Very High Very High Very High
Toxicity 2 98.56 Very High Very High Very High
Skin Cancer 6 98.00 Very High Very High Very High
Natriuresis 2 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, fluoxetine-induced activation of both the cAMP-response element-binding (CREB) protein and extracellular signal-regulated protein kinases (ERK1/2), which was abolished by the selective inhibitor of MAP kinase kinase (MEK) 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene (U0126), and increased cyclin D1 expression.
Negative_regulation (inhibitor) of MAP associated with fluoxetine
1) Confidence 0.57 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18573488 Disease Relevance 0 Pain Relevance 1.00
Understanding the intercellular signalling pathways involved in nociception may lead to novel drugs, such as p38 mitogen-activated protein (MAP) kinase inhibitors, being used in the treatment of cough in the future.
Negative_regulation (inhibitors) of MAP associated with nociception and cough
2) Confidence 0.57 Published 2007 Journal Pulm Pharmacol Ther Section Abstract Doc Link 17189707 Disease Relevance 0.86 Pain Relevance 0.31
After clonidine treatment, in addition to a statistically significant reduction in SAP, DAP, MAP, and in NE and UNE (all p less than 0.01), a decrease in IVS (12.5 to 9.5 mm; p less than 0.01) and in PW (11.2 to 9.3 mm; p less than 0.01) thickness as well as in LVMI (152.3 to 108.6 g/m2; p less than 0.01) was observed in hypertensive patients.
Negative_regulation (reduction) of MAP associated with hypertension and clonidine
3) Confidence 0.57 Published 1987 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2455168 Disease Relevance 0.51 Pain Relevance 0.48
CONCLUSION: Our data show that despite to fluid challenge, we could not prevent MAP decrease in Group A, even if it is more marked in Group B.


Negative_regulation (decrease) of MAP
4) Confidence 0.57 Published 2007 Journal Minerva Anestesiol Section Body Doc Link 17159758 Disease Relevance 0 Pain Relevance 0
We also show that this action involves inhibition of mitogen-activated protein (MAP) kinase (ERK2) activity, interference with ERK nuclear translocation, is independent of protein kinase C and has prostaglandin-dependent and prostaglandin-independent components.
Negative_regulation (inhibition) of MAP associated with kinase c
5) Confidence 0.57 Published 1999 Journal Nat. Med. Section Abstract Doc Link 10581086 Disease Relevance 1.13 Pain Relevance 0.78
Concerning these similarities, we investigated the function of cytokine-suppressive anti-inflammatory drugs (CSAIDs), which act via inhibition of stress-activated MAP-kinases, in regulation of expression of proteolytic enzymes and in vitro invasion of malignant melanoma cells.
Negative_regulation (inhibition) of MAP associated with stress, inflammation, cinod, skin cancer and cytokine
6) Confidence 0.57 Published 2002 Journal Clin. Exp. Metastasis Section Abstract Doc Link 11918086 Disease Relevance 0.63 Pain Relevance 0.39
By classifying PVI >15 as positive, a MAP decrease >25 mmHg could be predicted, with sensitivity, specificity, positive predictive, and negative predictive values of 0.79, 0.71, 0.73, and 0.77, respectively.
Negative_regulation (decrease) of MAP
7) Confidence 0.57 Published 2010 Journal Acta Anaesthesiol Scand Section Body Doc Link 20236098 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: 0.5 and 1.0 MAC isoflurane, sevoflurane and desflurane in N2O all increased ICP and reduced MAP and CPP in a dose-dependent and clinically similar manner.
Negative_regulation (reduced) of MAP
8) Confidence 0.57 Published 2003 Journal Acta Anaesthesiol Scand Section Body Doc Link 12904183 Disease Relevance 0 Pain Relevance 0
Inhibition of EGF-induced ERK/MAP kinase-mediated astrocyte proliferation by mu opioids: integration of G protein and beta-arrestin 2-dependent pathways.
Negative_regulation (Inhibition) of MAP in astrocyte associated with opioid
9) Confidence 0.42 Published 2009 Journal J. Neurochem. Section Title Doc Link 19457093 Disease Relevance 0.06 Pain Relevance 0.66
The three drugs significantly reduced MAP at a similar rate.
Negative_regulation (reduced) of MAP
10) Confidence 0.42 Published 1992 Journal Perit Dial Int Section Abstract Doc Link 1511045 Disease Relevance 0.51 Pain Relevance 0.40
CONCLUSION: We conclude that administration of alfentanil to propofol-fentanyl anesthetized patients with supratentorial cerebral tumors decreases MAP and CPP in a dose-related way, but does not influence subdural ICP, AVDO2 or the CO2-reactivity.


Negative_regulation (decreases) of MAP
11) Confidence 0.42 Published 2005 Journal Acta Anaesthesiol Scand Section Body Doc Link 15777290 Disease Relevance 0 Pain Relevance 0
Deterioration of clinical signs in CTS recurrency was reflected by the electrophysiological findings with an increasing loss of SNAP and MAP.
Negative_regulation (loss) of MAP
12) Confidence 0.42 Published 2005 Journal Handchir Mikrochir Plast Chir Section Body Doc Link 15997425 Disease Relevance 0 Pain Relevance 0
An inhibitor of stress-activated MAP-kinases reduces invasion and MMP-2 expression of malignant melanoma cells.
Negative_regulation (inhibitor) of MAP associated with stress and skin cancer
13) Confidence 0.42 Published 2002 Journal Clin. Exp. Metastasis Section Title Doc Link 11918086 Disease Relevance 0.64 Pain Relevance 0.46
Wortmannin, an inhibitor of phosphatidylinositol-3 kinase, or SB203580, an inhibitor of p38 MAP kinase, did not reduce AAP-induced toxicity, indicating that these enzymes do not play a major role in cell toxicity.
Negative_regulation (inhibitor) of MAP associated with toxicity and paracetamol
14) Confidence 0.42 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11562448 Disease Relevance 0.89 Pain Relevance 0.78
In the epidural anesthesia group, there were clinically important decreases in MAP and RPP after reaching T-10 and skin incision.
Negative_regulation (decreases) of MAP in skin associated with anesthesia and epidural
15) Confidence 0.42 Published 1990 Journal J Clin Anesth Section Abstract Doc Link 2189450 Disease Relevance 0 Pain Relevance 1.09
In all four groups a slight decrease in HR and SVR occurred while a marked decrease in arterial blood pressure (SAP, MAP, DAP) and cardiac output was seen.
Negative_regulation (decrease) of MAP in blood
16) Confidence 0.42 Published 1987 Journal Anaesthesist Section Abstract Doc Link 2892430 Disease Relevance 0.09 Pain Relevance 0.28
There was no difference in the degree of MAP decrease between CPB group and TEB group.
Negative_regulation (decrease) of MAP
17) Confidence 0.42 Published 1994 Journal Masui Section Abstract Doc Link 7861594 Disease Relevance 0.09 Pain Relevance 0.27
On the other hand, in patients with brain injury and elevated ICP opioids did not further increase ICP despite MAP decreases.
Negative_regulation (decreases) of MAP in brain associated with cva, opioid and brain injury
18) Confidence 0.42 Published 1994 Journal Anaesthesist Section Abstract Doc Link 8092451 Disease Relevance 1.12 Pain Relevance 0.76
Therefore, ICP often remains unaltered despite MAP decreases.
Negative_regulation (decreases) of MAP associated with cva
19) Confidence 0.42 Published 1994 Journal Anaesthesist Section Abstract Doc Link 8092451 Disease Relevance 1.11 Pain Relevance 0.68
Induction of anesthesia was associated with significantly decreased MAP in the placebo and the 10 micrograms/kg alfentanil groups and increased HR in all groups with little change in SNA.
Negative_regulation (decreased) of MAP associated with rapifen and anesthesia
20) Confidence 0.42 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8712395 Disease Relevance 0.12 Pain Relevance 0.51

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