INT106540

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 25
Disease Relevance 9.32
Pain Relevance 29.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
spinal 10
dorsal horn 4
glial cell 2
neurons 2
paw 2
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 146 100.00 Very High Very High Very High
qutenza 39 100.00 Very High Very High Very High
antagonist 131 99.98 Very High Very High Very High
Clonidine 6 99.98 Very High Very High Very High
allodynia 319 99.88 Very High Very High Very High
Spinal cord 123 99.84 Very High Very High Very High
intrathecal 315 99.78 Very High Very High Very High
Kinase C 65 99.68 Very High Very High Very High
Analgesic 178 99.56 Very High Very High Very High
neuralgia 1 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 837 99.88 Very High Very High Very High
INFLAMMATION 55 99.32 Very High Very High Very High
Hyperalgesia 32 99.32 Very High Very High Very High
Nervous System Injury 42 95.16 Very High Very High Very High
Injury 38 92.64 High High
Targeted Disruption 10 92.64 High High
Pain 106 90.56 High High
Hypersensitivity 4 90.16 High High
Nociception 87 89.00 High High
Sleep Disorders 30 74.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To see if protein kinase C (PKC) also participates in the phosphorylation of NR1, we used electron microscopic techniques to determine further where the phosphorylated NR1 subunits (pNR1) are expressed in the spinothalamic tract (STT) cells and immunohistochemistry to examine whether a PKC inhibitor, chelerythrine chloride, blocks the enhanced phosphorylation of NR1 on serine 896.
Spec (whether) Negative_regulation (blocks) of Phosphorylation (phosphorylation) of NR1 associated with spinothalamic tract and kinase c
1) Confidence 0.58 Published 2004 Journal Brain Res. Section Abstract Doc Link 15312791 Disease Relevance 0 Pain Relevance 0.97
Western blots showed that pretreatment with the PKC inhibitor caused a decrease in CAP-induced phosphorylation of NR1 protein.
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of NR1 protein associated with kinase c and qutenza
2) Confidence 0.58 Published 2004 Journal Brain Res. Section Abstract Doc Link 15312791 Disease Relevance 0 Pain Relevance 1.10
The phosphorylation levels of GluR1 and NR1 subunits decreased in parallel with those of phospho-Thr-34 DARPP-32, supporting the hypothesis that morphine challenge elicited a decrease in PKA activity in morphine-sensitized rats.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of NR1 associated with morphine
3) Confidence 0.57 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15287884 Disease Relevance 0 Pain Relevance 1.06
Therefore, it is possible that ketamine blocks NMDA receptor and inhibits intracellular PKA, PKC or signals activity, and then decreases NR1 phosphorylation.
Negative_regulation (decreases) of Phosphorylation (phosphorylation) of NR1 associated with kinase c, ketamine and nmda receptor
4) Confidence 0.56 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.70 Pain Relevance 1.60
induces NR1 phosphorylation, which is blocked by an IL-1R antagonist [12].
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of NR1 associated with antagonist
5) Confidence 0.56 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.44 Pain Relevance 0.87
In this study, western blots and immunofluorescence staining were employed to observe if pretreatment with a PKA inhibitor, N-[2-((p-bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide, HCl (H89), blocks the enhanced phosphorylation of NR1 on serine 897 following injection of CAP into the glabrous skin of one hind paw of anesthetized rats.
Negative_regulation (blocks) of Phosphorylation (phosphorylation) of NR1 in paw associated with qutenza
6) Confidence 0.55 Published 2002 Journal Neuroscience Section Abstract Doc Link 12435416 Disease Relevance 0 Pain Relevance 1.00
Intrathecal clonidine suppresses phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit in spinal dorsal horn neurons of rats with neuropathic pain.
Negative_regulation (suppresses) of Phosphorylation (phosphorylation) of NR1 in spinal associated with nmda receptor, neuropathic pain, dorsal horn neuron, clonidine and intrathecal
7) Confidence 0.50 Published 2008 Journal Anesth. Analg. Section Title Doc Link 18633054 Disease Relevance 0.10 Pain Relevance 1.47
However, the intrathecal injection of NMDAR antagonist D-2-amino-5-phosphonopentanoic acid significantly prevented serine phosphorylation of NMDAR NR-1 subunits induced by EA stimulation in the dorsal horn of spinal cord.
Negative_regulation (prevented) of Phosphorylation (phosphorylation) of NR-1 in dorsal horn associated with antagonist, dorsal horn, electroacupuncture, spinal cord and intrathecal
8) Confidence 0.43 Published 2007 Journal Am. J. Chin. Med. Section Abstract Doc Link 18186585 Disease Relevance 0 Pain Relevance 0.93
However, the intrathecal injection of NMDAR antagonist D-2-amino-5-phosphonopentanoic acid significantly prevented serine phosphorylation of NMDAR NR-1 subunits induced by EA stimulation in the dorsal horn of spinal cord.
Negative_regulation (prevented) of Phosphorylation (phosphorylation) of NMDAR in dorsal horn associated with antagonist, dorsal horn, electroacupuncture, spinal cord and intrathecal
9) Confidence 0.43 Published 2007 Journal Am. J. Chin. Med. Section Abstract Doc Link 18186585 Disease Relevance 0 Pain Relevance 0.93
Previous study suggests that ketamine combined with methamphetamine could down-regulate NR1 receptor phosphorylation in rats (phosphorylation site: serine 897) [29].
Negative_regulation (down) of Phosphorylation (phosphorylation) of NR1 receptor associated with ketamine
10) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.88 Pain Relevance 1.65
Previous study suggests that ketamine combined with methamphetamine could down-regulate NR1 receptor phosphorylation in rats (phosphorylation site: serine 897) [29].
Negative_regulation (regulate) of Phosphorylation (phosphorylation) of NR1 receptor associated with ketamine
11) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.88 Pain Relevance 1.65
Combining ketamine with LAA suppressed neuropathic pain in a quick and stable way, whereas, NMDAR phosphorylation and astrocytic activation were both much more suppressed than those of either single drug administration.
Negative_regulation (suppressed) of Phosphorylation (phosphorylation) of NMDAR associated with ketamine and neuropathic pain
12) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.73 Pain Relevance 1.74
Furthermore, the combination of drug administration exerted more powerful inhibition on NR1 phosphorylation and astrocytic activation.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of NR1
13) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.67 Pain Relevance 1.63
Applying IL-1R antagonist and glial inhibitor, attenuates NMDAR phosphorylation [48].
Negative_regulation (attenuates) of Phosphorylation (phosphorylation) of NMDAR associated with antagonist
14) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.43 Pain Relevance 0.86
Intrathecal application of NMDAR antagonist ketamine alleviated mechanical allodynia with decreased NMDAR phosphorylation in a quick but short response, whereas astrocytic cytotoxin LAA relieved mechanical allodynia with attenuated astrocytic activation in a late but persistent manner. 3.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of NMDAR associated with allodynia, ketamine, antagonist and intrathecal
15) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.48 Pain Relevance 1.56
The NR1 phosphorylation returned to high level at 24 h after ketamine (100 ?
Negative_regulation (returned) of Phosphorylation (phosphorylation) of NR1 associated with ketamine
16) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.21 Pain Relevance 1.04
The enhanced NR1 serine phosphorylation reversed within six hours.
Negative_regulation (reversed) of Phosphorylation (phosphorylation) of NR1
17) Confidence 0.40 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1208948 Disease Relevance 0.56 Pain Relevance 0.50
Thus, in the sensitized neurons suppression of the NR1 phosphorylation results in reduction of thermal hyperalgesia and a decrease in NR2B expression produces an inhibition of mechanical allodynia.
Negative_regulation (suppression) of Phosphorylation (phosphorylation) of NR1 in neurons associated with allodynia and thermal hyperalgesia
18) Confidence 0.40 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.64 Pain Relevance 0.87
Western blots showed that pretreatment with H89 caused a decrease in CAP-induced phosphorylation of NR1 protein in spinal cord segments L(4)-S(1).
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of NR1 protein in spinal cord segments associated with qutenza and spinal cord
19) Confidence 0.40 Published 2002 Journal Neuroscience Section Abstract Doc Link 12435416 Disease Relevance 0 Pain Relevance 1.13
N-methyl-D-aspartate antagonist inhibits NR-1 subunit phosphorylation of the spinal N-methyl-D-aspartate receptor induced by low frequency electroacupuncture.
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of N-methyl-D-aspartate receptor in spinal associated with nmda receptor, antagonist and electroacupuncture
20) Confidence 0.38 Published 2007 Journal Am. J. Chin. Med. Section Title Doc Link 18186585 Disease Relevance 0 Pain Relevance 0.90

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