INT106549

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Context Info
Confidence 0.35
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.83
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adcyap1) extracellular space (Adcyap1) extracellular region (Adcyap1)
Anatomy Link Frequency
regulatory T cell 1
dorsal horn 1
Adcyap1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 16 100.00 Very High Very High Very High
Dorsal horn 2 100.00 Very High Very High Very High
primary afferent fibers 1 100.00 Very High Very High Very High
nMDA receptor 2 99.36 Very High Very High Very High
Dorsal horn neuron 4 95.88 Very High Very High Very High
Inflammation 24 92.56 High High
Neurotransmitter 4 92.08 High High
Spinal cord 8 83.52 Quite High
antagonist 10 81.68 Quite High
Central nervous system 46 81.04 Quite High
Disease Link Frequency Relevance Heat
Nociception 9 100.00 Very High Very High Very High
Fatigue 22 98.24 Very High Very High Very High
Hypoxia 6 93.92 High High
INFLAMMATION 38 92.56 High High
Increased Venous Pressure Under Development 4 86.60 High High
Autoimmune Disease 30 85.68 High High
Ganglion Cysts 6 84.56 Quite High
Multiple Sclerosis 56 73.56 Quite High
Experimental Autoimmune Encephalomyelitis 4 73.36 Quite High
Disease 46 69.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a corollary, PACAP, which may be released from primary afferent fibers potentiates nociceptive transmission to the dorsal horn by interacting primarily with NMDA receptors.
PACAP Binding (interacting) of in dorsal horn associated with nociception, nmda receptor, primary afferent fibers and dorsal horn
1) Confidence 0.35 Published 2002 Journal Pain Section Abstract Doc Link 12435456 Disease Relevance 0.40 Pain Relevance 0.54
Treatment in PACAP/VIP postulated autoimmune neuropsychiatric fatigue-related disorders
PACAP Binding (Treatment) of associated with fatigue
2) Confidence 0.26 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 0.62 Pain Relevance 0.10
Given this previous data, we became interested in understanding more about PACAP/glutamate interactions at the cellular level in the night.


PACAP Binding (interactions) of associated with glutamate
3) Confidence 0.23 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0.14 Pain Relevance 0.20
They have key roles in blood vessels in the CNS84 and VIP is associated with maintaining functional integrity of the BBB.83 PACAP and VIP influence regulatory T cell (Treg)29 and other immune functions.
PACAP Binding (integrity) of in regulatory T cell
4) Confidence 0.23 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 0.67 Pain Relevance 0.24

General Comments

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