INT106552

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Context Info
Confidence 0.68
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 19
Total Number 22
Disease Relevance 9.72
Pain Relevance 5.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2) cytosol (Ntrk2) plasma membrane (Ntrk2)
kinase activity (Ntrk2)
Anatomy Link Frequency
brain 6
neurons 4
DA neurons 2
dorsal horn 2
spinal 2
Ntrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 331 99.80 Very High Very High Very High
spinal dorsal horn 16 99.68 Very High Very High Very High
Inflammation 42 99.64 Very High Very High Very High
depression 339 99.44 Very High Very High Very High
medulla 14 98.52 Very High Very High Very High
Dopamine 169 98.40 Very High Very High Very High
midbrain 52 98.28 Very High Very High Very High
Eae 43 97.92 Very High Very High Very High
Hyperalgesia 13 97.32 Very High Very High Very High
fluoxetine 76 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 179 99.88 Very High Very High Very High
Anxiety Disorder 106 99.64 Very High Very High Very High
INFLAMMATION 42 99.64 Very High Very High Very High
Depression 433 99.44 Very High Very High Very High
Hypersensitivity 46 97.36 Very High Very High Very High
Hyperalgesia 18 97.32 Very High Very High Very High
Nociception 48 96.80 Very High Very High Very High
Shock 40 96.54 Very High Very High Very High
Ganglion Cysts 239 93.24 High High
Sprains And Strains 10 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of the tyrosine kinase receptor that selectively binds BDNF, trkB, is increased in the spinal dorsal horn during inflammation as well.
Positive_regulation (increased) of Gene_expression (Expression) of trkB in spinal associated with inflammation and spinal dorsal horn
1) Confidence 0.68 Published 2002 Journal Pain Section Abstract Doc Link 12435470 Disease Relevance 1.09 Pain Relevance 0.73
It has been shown that long-term treatment with electro-convulsive shock, desipramine, fluoxetine, tranylcypromine, and sertraline all increased mRNA levels of TrkB in the rat brain.98 Recently, Rantamäki et al131,132 reported that not only the expression, but TrkB signaling, is rapidly activated by a variety of antidepressants in mouse medial prefrontal cortex (PFC) and hippocampus.
Positive_regulation (activated) of Gene_expression (expression) of TrkB in cortex associated with antidepressant, desipramine, shock, hippocampus and fluoxetine
2) Confidence 0.66 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.30 Pain Relevance 0.43
Noxious stimulation increases BDNF and trkB.FL production in the spinal dorsal horn [5-9] and brainstem [10,11], leading to hyperalgesia and the formation of nocifensive behaviors.
Positive_regulation (increases) of Gene_expression (production) of trkB in dorsal horn associated with medulla, hyperalgesia and spinal dorsal horn
3) Confidence 0.50 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.59 Pain Relevance 0.38
Thus, our results demonstrating attenuation in thermal and mechanical sensitivity in the absence of trkB.T1 could be because increased trkB.T1 expression induces increased intracellular calcium signaling which promotes hypersensitivity.
Positive_regulation (increased) of Gene_expression (expression) of trkB associated with hypersensitivity
4) Confidence 0.50 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.74 Pain Relevance 0.43
We show that calyx formation around type I hair cells in the vestibular sensory epithelia requires BDNF/TrkB signalling via the PLC?
Positive_regulation (requires) of Gene_expression (signalling) of TrkB in hair cells
5) Confidence 0.50 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0 Pain Relevance 0.04
docking sites (referred to as TrkBD mice) [13] results in a loss of vestibular neurons that is essentially indistinguishable from that of Trkb null mice (Trkb-/-), suggesting that the survival function of BDNF/TrkB is mediated predominantly through the cooperative action of these two docking sites, whereas the PLC?
Positive_regulation (mediated) of Gene_expression (/) of TrkB in neurons
6) Confidence 0.50 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0 Pain Relevance 0
Here we show that TRPC3 is overexpressed in vestibular neurons of TrkBPLC point mutants.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of TrkBPLC in neurons
7) Confidence 0.50 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0 Pain Relevance 0.05
T48 cells are TrkB stably transfected SN56 cells.
Positive_regulation (transfected) of Gene_expression (transfected) of TrkB
8) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.55 Pain Relevance 0.12
To test whether deoxygedunin triggers TrkB dimerization, we cotransfected GST-TrkB with HA-TrkB plasmid into HEK293 cells, and treated the cells with 0.5 µM of various gedunin derivatives for 30 min.
Positive_regulation (cotransfected) of Gene_expression (cotransfected) of TrkB
9) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0 Pain Relevance 0
To test whether deoxygedunin triggers TrkB dimerization, we cotransfected GST-TrkB with HA-TrkB plasmid into HEK293 cells, and treated the cells with 0.5 µM of various gedunin derivatives for 30 min.
Positive_regulation (cotransfected) of Gene_expression (cotransfected) of TrkB
10) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0 Pain Relevance 0
T48 and T62 cells, stably transfected with rat TrkB in SN56 cells were cultured in the same medium containing 300 µg/ml G418 [19].
Positive_regulation (transfected) of Gene_expression (transfected) of TrkB
11) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.27 Pain Relevance 0.07
Discrete populations of TrkB and TrkC/Runx3 expressing neurons are maintained in wild-type ganglia at E13.5 (Figure 4I, K), and throughout development.
Positive_regulation (populations) of Gene_expression (expressing) of TrkB in ganglia
12) Confidence 0.47 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.21 Pain Relevance 0.12
The expression of trkB.FL and trkB.T1 is conserved across species and throughout evolution, and trkB isoform expression is regulated during development when the dominant trkB isoform expression in the brain switches from trkB.FL to trkB.T1 [39].
Positive_regulation (switches) of Gene_expression (expression) of trkB in brain
13) Confidence 0.47 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.66 Pain Relevance 0.25
Transgenic mice overexpressing the full-length trkB receptor (TrkB.TK+) and showing increased trkB activity in brain, and their wild type (WT) littermates, were injected with the antidepressant fluoxetine or saline, and analyzed behaviorally in the forced swimming test paradigm and biochemically for the concentrations of brain monoamines and their metabolites. 4.
Spec (analyzed) Positive_regulation (overexpressing) of Spec (analyzed) Gene_expression (overexpressing) of trkB in brain associated with targeted disruption, antidepressant, monoamine and fluoxetine
14) Confidence 0.47 Published 2005 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16392030 Disease Relevance 0.19 Pain Relevance 0.50
However, recent studies suggest that a reduction in BDNF level in BDNF heterozygous knockout mice does not produce depression-like symptoms,229 although overexpression of TrkB reduces anxiety and depressive behavior in mice.230,231 On the other hand, overexpression of TrkB.T1 fails to induce a depression-like effect in the forced swim test.121 Thus, more in-depth studies are required to answer this question.
Positive_regulation (overexpression) of Gene_expression (overexpression) of TrkB associated with targeted disruption, depression, eae and anxiety disorder
15) Confidence 0.45 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.86 Pain Relevance 0.44
Further localization of TrkB occurs at the synaptic sites after neuroanal activity.55 Neuronal activity, therefore, is critical for synthesis and intracellular targeting of TrkB receptors.55 Thus, BDNF release and expression of TrkB receptors in a coordinated fashion are important for optimal synaptic response.
Positive_regulation (important) of Gene_expression (expression) of TrkB in Neuronal
16) Confidence 0.45 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.45 Pain Relevance 0.19
However, recent studies suggest that a reduction in BDNF level in BDNF heterozygous knockout mice does not produce depression-like symptoms,229 although overexpression of TrkB reduces anxiety and depressive behavior in mice.230,231 On the other hand, overexpression of TrkB.T1 fails to induce a depression-like effect in the forced swim test.121 Thus, more in-depth studies are required to answer this question.
Positive_regulation (overexpression) of Gene_expression (overexpression) of TrkB associated with targeted disruption, depression, eae and anxiety disorder
17) Confidence 0.45 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.72 Pain Relevance 0.47
Our results for stage-specific changes in neurotrophin expression are consistent with prior studies showing early loss of TrkC expression [11,18], abnormally increased expression of TrkB at E12.5 to E13.5, and late loss of TrkA [18].
Positive_regulation (increased) of Gene_expression (expression) of TrkB
18) Confidence 0.44 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.41 Pain Relevance 0.16
Another striking observation of our work was the almost 10-fold higher expression of Ntrk2, the gene encoding the neurotrophic tyrosine receptor kinase 2 TrkB, in SPF mice.
Positive_regulation (higher) of Gene_expression (expression) of Ntrk2
19) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0.26 Pain Relevance 0
Increased expression of the brain-derived neurotrophic factor receptor, TrkB, and the smoothened (SMO) receptor was also confirmed in SPIE treated cultures.
Positive_regulation (Increased) of Gene_expression (expression) of TrkB in brain
20) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.29

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