INT106553

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Context Info
Confidence 0.43
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 5.35
Pain Relevance 4.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
brain 4
dorsal 2
colon 2
vagus nerve 2
neural 2
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 226 100.00 Very High Very High Very High
bDMF 20 100.00 Very High Very High Very High
Inflammation 46 99.52 Very High Very High Very High
Serotonin 26 98.98 Very High Very High Very High
Transcranial magnetic stimulation 6 98.72 Very High Very High Very High
depression 202 98.26 Very High Very High Very High
vagus nerve 2 97.56 Very High Very High Very High
Hyperalgesia 8 97.52 Very High Very High Very High
Kinase C 84 97.44 Very High Very High Very High
agonist 5 96.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Colitis 2 99.86 Very High Very High Very High
Virus Diseases 94 99.68 Very High Very High Very High
Asthma 6 99.66 Very High Very High Very High
INFLAMMATION 49 99.52 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

4 98.36 Very High Very High Very High
Depression 262 98.26 Very High Very High Very High
Hyperalgesia 10 97.52 Very High Very High Very High
Disease 108 93.28 High High
Targeted Disruption 64 86.96 High High
Shock 8 83.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, intra-midbrain infusion of BDNF in rodents produces antidepressant-like effect in the forced swim test and learned helpless models of depression.134 Infusion of BDNF in the dorsal raphe nucleus also resulted in antidepressant-like effect in the learned helpless model of depression.136 Interestingly, the effects of BDNF on these behavioral paradigms were much longer lasting compared with classic antidepressants.135,137

Clinical studies of BDNF response in depressed patients before and after antidepressant treatment

Positive_regulation (lasting) of Positive_regulation (response) of BDNF in dorsal associated with antidepressant, depression, eae, midbrain and raphe
1) Confidence 0.43 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.70 Pain Relevance 0.80
Finally, with the accumulating evidence linking BDNF to synaptic plasticity, we investigated whether BDNF-induced hyperalgesia in normal mice involves the N-methyl-D-aspartate (NMDA) receptor.
Positive_regulation (accumulating) of Positive_regulation (linking) of BDNF associated with hyperalgesia
2) Confidence 0.43 Published 2002 Journal Pain Section Abstract Doc Link 12435470 Disease Relevance 1.03 Pain Relevance 1.10
In inflammatory state of colitis, TNBS induced upregulation of BDNF in dorsal root ganglia of both genotypes while BDNF(+/-) mice showing significantly lower sensitivity in the colon at 30 mm Hg and lower sensitivity in bladder than BDNF(+/+) mice.
Positive_regulation (induced) of Positive_regulation (upregulation) of BDNF in colon associated with colitis and inflammation
3) Confidence 0.41 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19932037 Disease Relevance 0.94 Pain Relevance 0.30
Similarly, increases in serum BDNF level by amitriptyline after 36 days, paroxetine after 4 or 8 weeks, or venalfaxine after 12 weeks of treatment to depressed patients were reported.145–147 Not only antidepressants but vagus nerve stimulation, repetitive transcranial magnetic stimulation,148 or electroconvulsive therapy149 to depressed patients also cause an increase in serum BDNF level in depressed patients.
Positive_regulation (cause) of Positive_regulation (increase) of BDNF in vagus nerve associated with antidepressant, transcranial magnetic stimulation, vagus nerve and endep
4) Confidence 0.40 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.22 Pain Relevance 0.51
Asthmatic airways contain elevated levels of neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF) albeit, their effect on neural activity is unclear.
Positive_regulation (elevated) of Positive_regulation (levels) of brain-derived neurotrophic factor in neural associated with asthma
5) Confidence 0.36 Published 2005 Journal Respir Physiol Neurobiol Section Abstract Doc Link 15848126 Disease Relevance 0.19 Pain Relevance 0.11
Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brain.
Positive_regulation (activate) of Positive_regulation (activate) of brain-derived neurotrophic factor in brain associated with antidepressant
6) Confidence 0.34 Published 2007 Journal Neuropsychopharmacology Section Title Doc Link 17314919 Disease Relevance 0 Pain Relevance 0.50
The molecular mechanisms by which CaRF regulates transcription are not fully understood, however our previous overexpression experiments indicated that the C-terminal region of CaRF was required for its ability to activate the Bdnf promoter IV reporter plasmid [14].
Positive_regulation (required) of Positive_regulation (activate) of Bdnf
7) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877716 Disease Relevance 0.13 Pain Relevance 0
Serotonin enhancement of synaptic plasticity is mediated by activation of CREB and increases in BDNF levels [140].
Positive_regulation (activation) of Positive_regulation (increases) of BDNF associated with bdmf and serotonin
8) Confidence 0.21 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2845130 Disease Relevance 1.10 Pain Relevance 0.44
The increase in IL-6 protein with NGF or BDNF stimulation without any inhibitors was statistically significant (p?
Positive_regulation (increase) of Positive_regulation (stimulation) of BDNF
9) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0 Pain Relevance 0
The increase in IL-6 protein with NGF or BDNF stimulation without any inhibitors was statistically significant (p?
Positive_regulation (with) of Positive_regulation (stimulation) of BDNF
10) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0 Pain Relevance 0
We previously described that BDV blocks ERK 1/2 activation in response to brain-derived neurotrophic factor (BDNF) [17].
Positive_regulation (activation) of Positive_regulation (activation) of brain-derived neurotrophic factor in brain associated with virus diseases
11) Confidence 0.09 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.67 Pain Relevance 0.31

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