INT106555

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Context Info
Confidence 0.48
First Reported 2002
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 15
Total Number 19
Disease Relevance 6.31
Pain Relevance 5.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2) cytosol (Ntrk2) plasma membrane (Ntrk2)
kinase activity (Ntrk2)
Anatomy Link Frequency
spinal 1
brain 1
Ntrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
intrathecal 9 99.98 Very High Very High Very High
Nerve growth factor 99 99.26 Very High Very High Very High
spinal dorsal horn 16 99.12 Very High Very High Very High
GABAergic 9 98.88 Very High Very High Very High
Inflammation 43 98.08 Very High Very High Very High
bDMF 91 98.04 Very High Very High Very High
Pain 53 96.32 Very High Very High Very High
agonist 189 95.16 Very High Very High Very High
allodynia 10 94.36 High High
Thermal hyperalgesia 4 93.80 High High
Disease Link Frequency Relevance Heat
Nociception 44 99.92 Very High Very High Very High
Targeted Disruption 133 98.60 Very High Very High Very High
INFLAMMATION 43 98.08 Very High Very High Very High
Hypersensitivity 43 98.04 Very High Very High Very High
Apoptosis 170 97.12 Very High Very High Very High
Pain 59 96.32 Very High Very High Very High
Neuropathic Pain 34 94.36 High High
Hyperalgesia 22 93.80 High High
Nervous System Injury 11 92.32 High High
Neuroblastoma 21 91.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Filter assay demonstrated that increasing concentrations of [3H]deoxygedunin progressively bound TrkB ECD but not ICD, indicating that TrkB ECD but not ICD selectively binds deoxygedunin.
TrkB Binding (bound) of
1) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0 Pain Relevance 0
Filter assay demonstrated that increasing concentrations of [3H]deoxygedunin progressively bound TrkB ECD but not ICD, indicating that TrkB ECD but not ICD selectively binds deoxygedunin.
TrkB Binding (binds) of
2) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0 Pain Relevance 0
To determine whether deoxygedunin directly binds TrkB, we conducted a ligand binding assay with [3H]deoxygedunin.
TrkB Spec (whether) Binding (binds) of
3) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0 Pain Relevance 0
TrkB is a membrane-bound neurotrophin receptor that phosphorylates itself, and members of the MAPK pathway, after binding of its ligand; the brain-derived neurotrophin (Bdnf) [28], [29].
TrkB Binding (binding) of in brain
4) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0.49 Pain Relevance 0
Few studies, however, have examined a specific role for trkB.T1.
trkB Spec (examined) Binding (role) of
5) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.98 Pain Relevance 0.52
Most studies have focused on trkB.FL as the receptor responsible for BDNF-mediated nociception, since antibodies specific for trkB.FL [12] and abrogation of trkB.FL activation using the trkBF616A transgenic mouse [14] attenuate thermal and mechanical hypersensitivity.
trkB Binding (abrogation) of associated with targeted disruption, nociception and hypersensitivity
6) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 1.05 Pain Relevance 0.56
Deoxygedunin might bind to different motif on TrkB ECD from that of 7,8-DHF and NAS.
TrkB Spec (might) Binding (bind) of
7) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.08 Pain Relevance 0.14
Conceivably, these two compounds share the same binding pocket on TrkB ECD.
TrkB Binding (pocket) of
8) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.07 Pain Relevance 0.15
This indicates that these compounds might act either directly through TrkB receptor or its downstream signaling effectors.
TrkB Spec (might) Binding (receptor) of
9) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.30 Pain Relevance 0.14
Conceivably, these two compounds share the same binding pocket on TrkB ECD.
TrkB Binding (binding) of
10) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.07 Pain Relevance 0.15
TrkB dimerization Assay
TrkB Binding (dimerization) of
11) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0 Pain Relevance 0
BDNF exerts effects on nociception by binding to trkB.FL and initiating intracellular signaling cascades that lead to transcriptional changes.
trkB Binding (binding) of associated with nociception
12) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.56 Pain Relevance 0.36
The interaction of neurotrophins with the Trk receptors is specific: NGF binds with TrkA, BDNF and NT 4 both bind with TrkB, and NT 3 binds with the highest affinity to TrkC but is also capable of signaling through TrkA and TrkB.
TrkB Binding (bind) of associated with nerve growth factor
13) Confidence 0.36 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.13 Pain Relevance 0.19
GST pull-down assay revealed that deoxygedunin robustly provoked TrkB dimerization with an effect even stronger than BDNF.
TrkB Binding (dimerization) of
14) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0 Pain Relevance 0
Deoxygedunin binds to the ECD domain of TrkB (Figure 3).
TrkB Binding (binds) of
15) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0 Pain Relevance 0.03
Expression of the tyrosine kinase receptor that selectively binds BDNF, trkB, is increased in the spinal dorsal horn during inflammation as well.
trkB Binding (binds) of in spinal associated with inflammation and spinal dorsal horn
16) Confidence 0.35 Published 2002 Journal Pain Section Abstract Doc Link 12435470 Disease Relevance 1.07 Pain Relevance 0.72
Using the TrkB inhibitor K-252a, or mice deficient for the common neurotrophin receptor p75(NTR), the regulation of GABAergic activity was shown specifically to be mediated by BDNF binding to the neurotrophin receptor TrkB.
TrkB Binding (binding) of associated with gabaergic
17) Confidence 0.35 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19812317 Disease Relevance 0 Pain Relevance 0.50
This compound binds TrkA, but not TrkB or TrkC, and causes receptor dimerization and phosphorylation.
TrkB Binding (binds) of
18) Confidence 0.21 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.52 Pain Relevance 0.12
They are also reduced following intrathecal injection of TrkB/Fc; a chimeric binding protein which sequesters BDNF [71].
TrkB Binding (injection) of associated with bdmf and intrathecal
19) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2918544 Disease Relevance 0.99 Pain Relevance 1.45

General Comments

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