INT106556

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 42
Total Number 44
Disease Relevance 34.71
Pain Relevance 17.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
hippocampus 21
brain 8
neurons 8
plasma 6
PFC 3
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 1516 100.00 Very High Very High Very High
Hippocampus 862 100.00 Very High Very High Very High
bDMF 108 100.00 Very High Very High Very High
GABAergic 9 99.98 Very High Very High Very High
gABA 9 99.92 Very High Very High Very High
neurotrophin 3 9 99.80 Very High Very High Very High
depression 1710 99.68 Very High Very High Very High
amygdala 172 98.68 Very High Very High Very High
Neuropeptide 23 98.16 Very High Very High Very High
antinociception 1 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Repression 42 100.00 Very High Very High Very High
Stress 593 99.98 Very High Very High Very High
Disease 293 99.90 Very High Very High Very High
Suicidal Behaviour 2095 99.88 Very High Very High Very High
Depression 2256 99.84 Very High Very High Very High
Cancer 38 99.84 Very High Very High Very High
Congenital Anomalies 176 99.80 Very High Very High Very High
Targeted Disruption 166 99.76 Very High Very High Very High
Infection 62 99.62 Very High Very High Very High
Mental Disorders 102 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with piperine (6.25-25 microM) for 72 h reversed the CORT-induced reduction of BDNF mRNA expression in cultured hippocampal neurons.
Negative_regulation (reversed) of Gene_expression (expression) of BDNF mRNA in neurons
1) Confidence 0.59 Published 2007 Journal Life Sci. Section Abstract Doc Link 17289085 Disease Relevance 0.34 Pain Relevance 0.28
Our study shows that developmental exposure to low levels of MeHg predisposes mice to depression and induces epigenetic suppression of BDNF gene expression in the hippocampus.
Negative_regulation (suppression) of Gene_expression (expression) of BDNF gene in hippocampus associated with depression and hippocampus
2) Confidence 0.58 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18485098 Disease Relevance 0.24 Pain Relevance 0.44
Altogether, these studies suggest that although BDNF expression is repressed or induced by stress or antidepressants by different mechanisms, epigenetic regulation of the BDNF gene plays an important role in depression and in the mechanisms of action of antidepressants.


Negative_regulation (repressed) of Gene_expression (expression) of BDNF associated with stress, antidepressant and depression
3) Confidence 0.58 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.11 Pain Relevance 0.32
We observed that corticosterone selectively decreased the expression of transcripts II and IV, but not transcripts I or III, in both the frontal cortex and hippocampus.92 Two other recent studies suggest that immobilization stress decreases total BDNF expression, along with a specific decrease in exon IV in the hippocampus96 and hypothalamus.97 These studies suggest that the decrease of BDNF mRNA expression by glucocorticoids may be due to a decrease in expression of the specific BDNF transcripts that contain exons II and IV.


Negative_regulation (decreases) of Gene_expression (expression) of BDNF in hippocampus associated with stress, urological neuroanatomy and hippocampus
4) Confidence 0.58 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.51 Pain Relevance 0.27
Based on these studies, the neurotrophin hypothesis of depression was proposed, which suggests that stress and depression is associated with decreased expression of BDNF and that antidepressants alleviate depressive behavior by increasing its level.15,16 This is quite relevant given that BDNF is involved in synaptic plasticity and, as earlier mentioned, compromised synaptic and structural plasticity have been shown to be associated with depression.
Negative_regulation (decreased) of Gene_expression (expression) of BDNF associated with stress, antidepressant and depression
5) Confidence 0.58 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.06 Pain Relevance 0.32
Several studies have shown that exposure of exogenous corticosterone (to mimic the stress effect) also reduces BDNF expression in rodent hippocampus, similar to that observed in various pre-clinical stress models.83,89–91 Recently, we examined the effects of corticosterone treatment on BDNF expression in detail and found that the mRNA level of BDNF was not only decreased in the hippocampus but that the frontal cortex also showed significantly reduced expression of BDNF.92 This suggests that the effects of glucocorticoids on BDNF are not limited to the hippocampus; other brain areas are also equally affected.
Negative_regulation (reduces) of Gene_expression (expression) of BDNF in hippocampus associated with stress, urological neuroanatomy and hippocampus
6) Confidence 0.58 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.74 Pain Relevance 0.38
Interestingly, when we divided suicide subjects into those who had depression and those who had another psychiatric disorder, we found that the decrease in expression of BDNF was present in all suicide subjects regardless of psychiatric diagnosis.
Negative_regulation (decrease) of Gene_expression (expression) of BDNF associated with mental disorders, suicidal behaviour and depression
7) Confidence 0.58 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.26 Pain Relevance 0.26
We observed that corticosterone selectively decreased the expression of transcripts II and IV, but not transcripts I or III, in both the frontal cortex and hippocampus.92 Two other recent studies suggest that immobilization stress decreases total BDNF expression, along with a specific decrease in exon IV in the hippocampus96 and hypothalamus.97 These studies suggest that the decrease of BDNF mRNA expression by glucocorticoids may be due to a decrease in expression of the specific BDNF transcripts that contain exons II and IV.


Negative_regulation (decrease) of Gene_expression (expression) of BDNF in hippocampus associated with stress, urological neuroanatomy and hippocampus
8) Confidence 0.58 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.61 Pain Relevance 0.33
Selective inhibition of BDNF expression by i.t. antisense oligodeoxynucleotide treatment produces antinociception in normal mice and attenuates carrageenan-induced hyperalgesia.
Negative_regulation (inhibition) of Gene_expression (expression) of BDNF associated with antinociception and hyperalgesia
9) Confidence 0.58 Published 2002 Journal Pain Section Abstract Doc Link 12435470 Disease Relevance 1.21 Pain Relevance 0.92
As with adult suicide subjects, we found that protein expression of BDNF was significantly decreased in the PFC of teenaged suicide subjects.
Negative_regulation (decreased) of Gene_expression (expression) of BDNF associated with suicidal behaviour
10) Confidence 0.50 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.00 Pain Relevance 0.27
Several lines of evidence suggest that BDNF is involved in depression, such that the expression of BDNF is decreased in depressed patients.
Negative_regulation (decreased) of Gene_expression (expression) of BDNF associated with depression
11) Confidence 0.50 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2732010 Disease Relevance 0.88 Pain Relevance 0.30
Conversely, an antidepressant treatment reverses repression of BDNF expression likely by inducing H3 acetylation and H3-K4 methylation, acting as histone codes for transcriptional activation, at the BDNF promoter region [49].
Negative_regulation (reverses) of Gene_expression (expression) of BDNF associated with antidepressant, repression and bdmf
12) Confidence 0.48 Published 2010 Journal Mol Brain Section Body Doc Link PMC2848031 Disease Relevance 0.70 Pain Relevance 0.80
This hypothesis is based on the evidence that stress can decrease the expression of BDNF and lead to the atrophy of the same populations of stress-vulnerable hippocampal neurons, while electroconvulsive therapy (ECT) and antidepressants increase BDNF expression and may reverse or block the atrophy and cell loss resulting from stress and depression.5 In the past decade, this novel hypothesis has greatly changed the landscape for human and animal research on MDD.
Negative_regulation (decrease) of Gene_expression (expression) of BDNF in neurons associated with stress, antidepressant, depression and frailty
13) Confidence 0.43 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022309 Disease Relevance 1.01 Pain Relevance 0.74
Treatment with piperine (6.25-25 microM) for 72 h reversed the CORT-induced reduction of BDNF mRNA expression in cultured hippocampal neurons.
Negative_regulation (reduction) of Gene_expression (expression) of BDNF mRNA in neurons
14) Confidence 0.43 Published 2007 Journal Life Sci. Section Abstract Doc Link 17289085 Disease Relevance 0.34 Pain Relevance 0.28
Increasing evidence demonstrates that suicidal behavior is also associated with lower expression of BDNF, which may be independent from depression.
Negative_regulation (lower) of Gene_expression (expression) of BDNF associated with suicidal behaviour and depression
15) Confidence 0.42 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2732010 Disease Relevance 1.01 Pain Relevance 0.31
Also, in a post-mortem study of depressed patients, a reduction in BDNF expression was reported [37].
Negative_regulation (reduction) of Gene_expression (expression) of BDNF associated with bdmf
16) Confidence 0.42 Published 2010 Journal Mol Brain Section Body Doc Link PMC2848031 Disease Relevance 0.62 Pain Relevance 0.67
It is entirely possible that the downregulation of Bdnf expression in postnatal ears [37-39] is different in the two hair cell types and thus provides the proper signalling for afferent transformation into calyces.
Spec (possible) Negative_regulation (downregulation) of Gene_expression (expression) of Bdnf in hair cell
17) Confidence 0.42 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0.05 Pain Relevance 0
Both hippocampal cell proliferation and BDNF mRNA expression were down-regulated in GR-i mice, and these alterations were reversed by chronic agomelatine and fluoxetine treatments, whereas GR mRNA down-regulation was reversed only by agomelatine.
Negative_regulation (down-regulated) of Gene_expression (expression) of BDNF mRNA associated with fluoxetine
18) Confidence 0.40 Published 2010 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 19775499 Disease Relevance 0.39 Pain Relevance 0.74
In our study, real-time PCR experiments revealed a marked decrease in BDNF expression in hippocampus of mice submitted to our protocol of depression, when assessed at both the 6- and the 24-h time-points (an approximate 50% reduction).
Negative_regulation (decrease) of Gene_expression (expression) of BDNF in hippocampus associated with depression and hippocampus
19) Confidence 0.40 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.25 Pain Relevance 0.70
To analyze the functional effects of these changes in BDNF in Huntington's disease, we disrupted the expression of bdnf in a transgenic mouse model by cross-mating bdnf(+/ -) mice with R6/1 mice.
Negative_regulation (disrupted) of Gene_expression (expression) of bdnf associated with targeted disruption and disease
20) Confidence 0.38 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15342740 Disease Relevance 0.53 Pain Relevance 0.06

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