INT106560

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.14
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.47
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2) cytosol (Ntrk2) extracellular region (Ntf3)
plasma membrane (Ntrk2) cytoplasmic membrane-bounded vesicle (Ntf3) kinase activity (Ntrk2)
Anatomy Link Frequency
brain 2
Ntf3 (Mus musculus)
Ntrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
neurotrophin 3 6 100.00 Very High Very High Very High
agonist 2 99.98 Very High Very High Very High
Hyperalgesia 14 99.52 Very High Very High Very High
Nerve growth factor 58 99.04 Very High Very High Very High
antinociception 2 84.68 Quite High
nMDA receptor antagonist 2 79.28 Quite High
Inflammation 20 75.00 Quite High
Peripheral nervous system 2 72.12 Quite High
intrathecal 2 68.00 Quite High
spinal dorsal horn 2 65.80 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 20 99.52 Very High Very High Very High
Nociception 8 75.28 Quite High
INFLAMMATION 14 75.00 Quite High
Ganglion Cysts 134 70.24 Quite High
Targeted Disruption 28 5.00 Very Low Very Low Very Low
Apoptosis 16 5.00 Very Low Very Low Very Low
Death 14 5.00 Very Low Very Low Very Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 12 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with a trkB.FL-mediated mechanism, the i.t. administration of another trkB ligand, neurotrophin-4/5, also produces hyperalgesia while the trkC agonist neurotrophin-3, which weakly cross-reacts with trkB, has little effect.
neurotrophin-3 Binding (cross) of trkB associated with hyperalgesia and agonist
1) Confidence 0.14 Published 2002 Journal Pain Section Abstract Doc Link 12435470 Disease Relevance 1.16 Pain Relevance 1.14
Consistent with a trkB.FL-mediated mechanism, the i.t. administration of another trkB ligand, neurotrophin-4/5, also produces hyperalgesia while the trkC agonist neurotrophin-3, which weakly cross-reacts with trkB, has little effect.
neurotrophin-3 Binding (reacts) of trkB associated with hyperalgesia and agonist
2) Confidence 0.14 Published 2002 Journal Pain Section Abstract Doc Link 12435470 Disease Relevance 1.16 Pain Relevance 1.14
Modified from Airaksinen and Saarma (2002). b The neurotrophins, viz. nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) bind with high affinity to the tyrosine kinase receptors trkA, trkB and trkC, respectively.
NT3 Binding (bind) of trkB in brain associated with neurotrophin 3 and nerve growth factor
3) Confidence 0.12 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.28
Modified from Airaksinen and Saarma (2002). b The neurotrophins, viz. nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) bind with high affinity to the tyrosine kinase receptors trkA, trkB and trkC, respectively.
neurotrophin 3 Binding (bind) of trkB in brain associated with neurotrophin 3 and nerve growth factor
4) Confidence 0.12 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox