INT106565

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 6.98
Pain Relevance 9.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cnr1) plasma membrane (Cnr1) response to stress (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
spinal 4
ventromedial hypothalamic nucleus 3
amygdala 3
substantia nigra 2
smooth muscle 2
Cnr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 214 100.00 Very High Very High Very High
antagonist 152 100.00 Very High Very High Very High
agonist 137 100.00 Very High Very High Very High
Cannabinoid receptor 98 100.00 Very High Very High Very High
intrathecal 16 99.84 Very High Very High Very High
tail-flick 1 99.76 Very High Very High Very High
Ventral tegmentum 105 99.68 Very High Very High Very High
Substantia nigra 4 99.66 Very High Very High Very High
Neurotransmitter 17 99.44 Very High Very High Very High
anticonvulsant 5 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 18 100.00 Very High Very High Very High
Obesity 81 99.16 Very High Very High Very High
Li-fraumeni Syndrome 16 98.88 Very High Very High Very High
Neuropathic Pain 109 98.84 Very High Very High Very High
Depression 100 98.40 Very High Very High Very High
Apoptosis 23 98.32 Very High Very High Very High
Hyperalgesia 15 98.32 Very High Very High Very High
Urological Neuroanatomy 57 97.64 Very High Very High Very High
Spasticity 43 96.08 Very High Very High Very High
Aids-related Complex 1 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This treatment resulted in a decrease in lumbar spinal CB1 receptor expression accompanied by a decrease in the response thresholds to both innocuous tactile and noxious thermal stimuli.
Negative_regulation (decrease) of Gene_expression (expression) of CB1 receptor in spinal associated with cannabinoid receptor
1) Confidence 0.59 Published 2002 Journal Pain Section Abstract Doc Link 12435473 Disease Relevance 0.32 Pain Relevance 0.81
The presence of immunoreactive TRPV1 in uNK cells was observed from day 10 until degranulation, contrary to CB1 expression that diminishes around day 12.
Negative_regulation (diminishes) of Gene_expression (expression) of CB1
2) Confidence 0.54 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0.23 Pain Relevance 0.07
The distinctive expression of TRPV1 and the loss of CB1 expression could be related to the induction of the apoptosis that occurs in these cells during this period [27], as has been suggested for other cell types [43].
Negative_regulation (loss) of Gene_expression (expression) of CB1 associated with apoptosis
3) Confidence 0.54 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0.23 Pain Relevance 0.08
1) Detection of CB1R messenger RNA expression
Negative_regulation (messenger) of Gene_expression (expression) of CB1R
4) Confidence 0.43 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 0.24 Pain Relevance 0.07
For peripheral delivery of the CB1 antagonist, we performed daily intraperitoneal injection of SR141716 at a dose of 10 mg · kg?
Negative_regulation (delivery) of Gene_expression (antagonist) of CB1 associated with antagonist
5) Confidence 0.42 Published 2008 Journal Diabetes Section Body Doc Link PMC2570394 Disease Relevance 0 Pain Relevance 0.32
Higher levels of CB1 receptor expression in frontal, cingulated and piriform cortex, without differences in temporal, parietal and occipital cortex, were observed in obese Zucker rats, with respect to their lean littermates.
Negative_regulation (levels) of Gene_expression (expression) of CB1 receptor in piriform cortex associated with obesity
6) Confidence 0.42 Published 2008 Journal Brain Res. Section Abstract Doc Link 18722357 Disease Relevance 0.57 Pain Relevance 0.37
In contrast, a significant decrease in the cannabinoid CB1 receptor gene expression was found in caudate-putamen, central amygdala and ventromedial hypothalamic nucleus.
Negative_regulation (decrease) of Gene_expression (expression) of cannabinoid CB1 receptor gene in ventromedial hypothalamic nucleus associated with cannabinoid and amygdala
7) Confidence 0.40 Published 2008 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17964122 Disease Relevance 0.08 Pain Relevance 0.48
Spatiotemporal expression of CB1, CB2 and TRPV1 receptor - Days 12 to 14 of pregnancy
Negative_regulation (Spatiotemporal) of Gene_expression (expression) of CB1
8) Confidence 0.40 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0 Pain Relevance 0.04
In other brain regions, such as the amygdala, the antinociceptive effects of intrabasolateral amygdala injection of WIN55212 in formalin and tail-flick tests were abolished by CB1 receptor antagonism but not CB2 receptor antagonism in naïve rats (Hasanein et al., 2007).
Neg (not) Negative_regulation (abolished) of Gene_expression (antagonism) of CB1 receptor in amygdala associated with tail-flick, antinociceptive and amygdala
9) Confidence 0.37 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.43 Pain Relevance 0.73
4) or mixed CB1 and CB2 receptor antagonists followed by saline vehicle on days 14 and 15 (n?
Negative_regulation (mixed) of Gene_expression (antagonists) of CB1 associated with antagonist
10) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0 Pain Relevance 0.31
We then administered concomitant CB1 and CB2 receptor antagonists/inverse agonists (AM281 and AM630, 1 mg.kg?
Negative_regulation (administered) of Gene_expression (/) of CB1 associated with antagonist and agonist
11) Confidence 0.37 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2878341 Disease Relevance 0.84 Pain Relevance 1.17
Lack of a direct effect of CB1/CB2 agonist CP55,940 and the nonselective agonist anandamide on carbachol induced contractions indicated the absence of direct CB mediated functions of isolated detrusor smooth muscle.[34]
Negative_regulation (effect) of Gene_expression (/) of CB1 in smooth muscle associated with agonist and overactive bladder
12) Confidence 0.33 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2878434 Disease Relevance 0.31 Pain Relevance 0.25
After a bilateral injection of the vectors into the major part of the VTA (Figure 2B), the CB1R shRNA, but not its scrambled sequence, significantly suppressed CB1R expression in the VTA (Figure 2C) and LFS-induced LTD in HU210-treated rats (Figure 2D,E).
Negative_regulation (suppressed) of Gene_expression (expression) of CB1R associated with ventral tegmentum, li-fraumeni syndrome and depression
13) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.95 Pain Relevance 1.11
Thus, CB1-mediated inhibitory effects on these two neurotransmitter
Negative_regulation (inhibitory) of Gene_expression (effects) of CB1 associated with neurotransmitter
14) Confidence 0.30 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2593468 Disease Relevance 0.35 Pain Relevance 0.56
Even synthetic CB1 receptor agonists may have variable effects in the CNS, as a result of their action at different CB receptors and individual variability in CB receptor expression.44

Conclusion

Negative_regulation (variability) of Gene_expression (expression.44) of CB1 associated with agonist
15) Confidence 0.22 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835560 Disease Relevance 0.30 Pain Relevance 0.42
On days 16 and 31, tyrosine hydroxylase gene expression in ventral tegmental area and substantia nigra and cannabinoid CB1 receptor gene expression in the CPu decreased (approximately 45-50% from vehicle).
Negative_regulation (decreased) of Gene_expression (expression) of CB1 receptor in substantia nigra associated with ventral tegmentum, cannabinoid and substantia nigra
16) Confidence 0.18 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15936043 Disease Relevance 0.09 Pain Relevance 0.94
The expression of CB1R in CCI rats was substantially attenuated by intrathecal treatment with either the GR antagonist RU38486 or a GR antisense oligonucleotide given twice daily for postoperative day 1-6, whereas the expression of spinal CB1R was enhanced following intrathecal administration of a GR sense oligonucleotide twice daily for postoperative day 1-6.
Negative_regulation (attenuated) of Gene_expression (expression) of CB1R in spinal associated with nervous system injury, antagonist and intrathecal
17) Confidence 0.16 Published 2007 Journal Pain Section Abstract Doc Link 17258396 Disease Relevance 0.69 Pain Relevance 0.63
In contrast, a significant decrease in the cannabinoid CB1 receptor gene expression was found in caudate-putamen, central amygdala and ventromedial hypothalamic nucleus.
Negative_regulation (decrease) of in amygdala Gene_expression (expression) of cannabinoid CB1 receptor gene in ventromedial hypothalamic nucleus associated with cannabinoid and amygdala
18) Confidence 0.14 Published 2008 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17964122 Disease Relevance 0.08 Pain Relevance 0.48
On the other hand, CB-1 antagonists, like SR141716A, decrease the activation threshold, increasing the response to mechanic and thermic stimuli.
Negative_regulation (decrease) of Gene_expression (antagonists) of CB-1 associated with antagonist
19) Confidence 0.05 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2771268 Disease Relevance 1.19 Pain Relevance 1.11

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