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Context Info
Confidence 0.60
First Reported 2002
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.35
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Jak1) cytoplasm (Jak1)
Jak1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 4 99.74 Very High Very High Very High
fluoxetine 3 98.68 Very High Very High Very High
Kinase C 3 98.30 Very High Very High Very High
ischemia 3 89.76 High High
Opioid 4 88.84 High High
Serotonin 2 88.60 High High
sSRI 2 86.12 High High
MU agonist 1 82.92 Quite High
antidepressant 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Stress 1 98.58 Very High Very High Very High
Cv Unclassified Under Development 3 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine induced the phosphorylation of JAK2, yet not JAK1, in the area at risk.
Phosphorylation (phosphorylation) of JAK1 associated with morphine
1) Confidence 0.60 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16517948 Disease Relevance 0.25 Pain Relevance 0.86
Protein kinase C (PKC)-delta, PKC-gamma, stress-activated protein kinase, cAMP-dependent protein kinase beta isoform, Janus protein kinase, and phosphofructokinase M were all down regulated chronically with citalopram and fluoxetine, but not with acute fluoxetine.
Neg (not) Phosphorylation (regulated) of Janus protein kinase associated with stress, kinase c and fluoxetine
2) Confidence 0.19 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12435479 Disease Relevance 0.10 Pain Relevance 0.65

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