INT106574

Context Info Confidence 0.60 First Reported 2002 Last Reported 2006 Negated 1 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.35 Pain Relevance 1.50

nucleus (Jak1) cytoplasm (Jak1)

Jak1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Morphine 4 99.74 fluoxetine 3 98.68 Kinase C 3 98.30 ischemia 3 89.76 Opioid 4 88.84 Serotonin 2 88.60 sSRI 2 86.12 MU agonist 1 82.92 antidepressant 1 75.00

Disease Link Frequency Relevance Heat Stress 1 98.58 Cv Unclassified Under Development 3 89.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Morphine induced the phosphorylation of JAK2, yet not JAK1, in the area at risk.

Phosphorylation (phosphorylation) of JAK1 associated with morphine

1) Confidence 0.60 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16517948 Disease Relevance 0.25 Pain Relevance 0.86

Protein kinase C (PKC)-delta, PKC-gamma, stress-activated protein kinase, cAMP-dependent protein kinase beta isoform, Janus protein kinase, and phosphofructokinase M were all down regulated chronically with citalopram and fluoxetine, but not with acute fluoxetine.

Neg (not) Phosphorylation (regulated) of Janus protein kinase associated with stress, kinase c and fluoxetine

2) Confidence 0.19 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12435479 Disease Relevance 0.10 Pain Relevance 0.65

General Comments

This test has worked.