INT106585

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Context Info
Confidence 0.76
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.21
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain structures 1
Rabif (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 6 99.92 Very High Very High Very High
Neurotransmitter 6 99.92 Very High Very High Very High
Hippocampus 6 97.32 Very High Very High Very High
antidepressant 12 95.60 Very High Very High Very High
amygdala 6 93.00 High High
tricyclic antidepressant 3 86.68 High High
tolerance 40 5.00 Very Low Very Low Very Low
sSRI 8 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 3 82.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mss4 was also overexpressed in other brain structures as judged by in situ hybridization.
Gene_expression (overexpressed) of Mss4 in brain structures
1) Confidence 0.76 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435800 Disease Relevance 0.07 Pain Relevance 0.53
The kinetics of the up-regulation of Mss4 gene expression measured by Northern blot during the imipramine, tianeptine, or fluoxetine treatments are consistent with an antidepressant effect that occurs after 3 weeks.
Gene_expression (expression) of Mss4 associated with antidepressant and fluoxetine
2) Confidence 0.76 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435800 Disease Relevance 0.08 Pain Relevance 0.60
Mss4 protein has the properties of a guanine nucleotide exchange factor, interacting with several members of the Rab family implicated in Ca(2+)-dependent exocytosis of neurotransmitters.
Gene_expression (has) of Mss4 associated with neurotransmitter
3) Confidence 0.66 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435800 Disease Relevance 0.06 Pain Relevance 0.45
The dashed lines are the null clines through, respectively, (R0,M0) and (Rss,Mss)
Gene_expression (clines) of Mss
4) Confidence 0.08 Published 2008 Journal AAPS J Section Body Doc Link PMC2751452 Disease Relevance 0 Pain Relevance 0
The dashed lines are the null clines through (R0,M0) and through (Rss,Mss)
Gene_expression (clines) of Mss
5) Confidence 0.08 Published 2008 Journal AAPS J Section Body Doc Link PMC2751452 Disease Relevance 0 Pain Relevance 0

General Comments

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