INT106596

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0
Pain Relevance 4.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dnm2) cytoskeleton (Dnm2) nucleus (Dnm2)
GTPase activity (Dnm2) protein complex (Dnm2) cytoplasm (Dnm2)
Anatomy Link Frequency
spinal cord 3
Dnm2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 13 99.60 Very High Very High Very High
Immobilon 21 98.96 Very High Very High Very High
opioid receptor 17 98.88 Very High Very High Very High
Opioid 7 97.92 Very High Very High Very High
Morphine 11 97.04 Very High Very High Very High
analgesia 2 96.56 Very High Very High Very High
Enkephalin 1 95.84 Very High Very High Very High
Potency 2 95.64 Very High Very High Very High
Analgesic 1 95.32 Very High Very High Very High
tolerance 4 94.64 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In other mice, spinal cord was removed for [(3)H]DAMGO binding studies or GRK-2 and DYN-2 protein and mRNA abundance were determined.
Transcription (abundance) of DYN-2 protein in spinal cord associated with spinal cord
1) Confidence 0.69 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435815 Disease Relevance 0 Pain Relevance 1.65
NTX decreased protein and mRNA abundance of GRK-2 (-32%; -48%) and DYN-2 (-25%; -29%) in spinal cord at 0 h.
Transcription (abundance) of DYN-2 in spinal cord associated with spinal cord
2) Confidence 0.58 Published 2003 Journal Synapse Section Abstract Doc Link 12872295 Disease Relevance 0 Pain Relevance 0.92
Results indicate that etorphine induced dose-dependent regulation of muOR density, DYN-2 proteins, and mRNA abundance in mouse spinal cord.
Transcription (abundance) of DYN-2 in spinal cord associated with spinal cord and immobilon
3) Confidence 0.53 Published 2005 Journal Synapse Section Abstract Doc Link 15765525 Disease Relevance 0 Pain Relevance 0.91
These data indicate that mu-opioid receptor density, determined in radioligand binding assays, and immunoreactive dynamin-2 abundance are regulated by continuous, but not intermittent, opioid ligand treatment.
Transcription (abundance) of immunoreactive dynamin-2 associated with opioid receptor and opioid
4) Confidence 0.40 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15363980 Disease Relevance 0 Pain Relevance 1.02

General Comments

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