INT106599

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 0.28
Pain Relevance 7.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dnm2) cytoskeleton (Dnm2) nucleus (Dnm2)
GTPase activity (Dnm2) protein complex (Dnm2) cytoplasm (Dnm2)
Anatomy Link Frequency
spinal cord 1
Dnm2 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 23 99.50 Very High Very High Very High
opioid receptor 34 99.42 Very High Very High Very High
Immobilon 44 99.14 Very High Very High Very High
Kinase C 1 98.00 Very High Very High Very High
Spinal cord 27 97.32 Very High Very High Very High
MU agonist 20 96.40 Very High Very High Very High
agonist 10 95.52 Very High Very High Very High
antagonist 12 94.88 High High
mu opioid receptor 14 92.44 High High
Opioid 5 91.64 High High
Disease Link Frequency Relevance Heat
Disease 4 86.76 High High
Generalized Epilepsy 3 79.40 Quite High
Depression 4 59.08 Quite High
Epilepsy 15 50.00 Quite Low
Convulsion 34 5.00 Very Low Very Low Very Low
Ataxia 7 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Hearing Impairment 4 5.00 Very Low Very Low Very Low
Neurological Disease 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been suggested that muOR down-regulation may depend upon increases in Dynamin-2 (DYN-2) proteins.
Positive_regulation (increases) of DYN-2
1) Confidence 0.69 Published 2005 Journal Synapse Section Abstract Doc Link 15765525 Disease Relevance 0 Pain Relevance 0.83
It has been suggested that muOR down-regulation may depend upon increases in Dynamin-2 (DYN-2) proteins.
Positive_regulation (increases) of Dynamin-2
2) Confidence 0.69 Published 2005 Journal Synapse Section Abstract Doc Link 15765525 Disease Relevance 0 Pain Relevance 0.83
Higher infusion doses significantly down-regulated muOR density, increased DYN-2 protein abundance, and decreased DYN-2 mRNA.
Positive_regulation (increased) of DYN-2 protein
3) Confidence 0.50 Published 2005 Journal Synapse Section Abstract Doc Link 15765525 Disease Relevance 0 Pain Relevance 0.89
Finally, the decrease in DYN-2 mRNA may be related to stabilization of DYN-2 protein abundance, which might inhibit transcription.
Positive_regulation (stabilization) of DYN-2 protein
4) Confidence 0.45 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435815 Disease Relevance 0 Pain Relevance 1.04
The alternate splice in exon 10 that occurs in Dnm1 and Dnm2, but not Dnm3 or in the dynamin-related protein Drp, has been recognized previously.
Positive_regulation (occurs) of Dnm2
5) Confidence 0.45 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2916854 Disease Relevance 0.28 Pain Relevance 0.06
Continuous (7 days) s.c. infusion of etorphine (200 microg/kg/day) decreased immunoreactive mu-opioid receptor (approximately -35%) and [3H] DAMGO binding (approximately -30%), and concurrently increased dynamin-2 abundance (approximately +40%).
Positive_regulation (increased) of dynamin-2 associated with opioid receptor and immobilon
6) Confidence 0.33 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15363980 Disease Relevance 0 Pain Relevance 1.12
Mu-opioid receptor up-regulation has been associated with decreases in the trafficking protein dynamin-2, whereas mu-opioid receptor down-regulation produces an increase in dynamin-2 abundance.
Positive_regulation (increase) of dynamin-2 associated with opioid receptor
7) Confidence 0.33 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15363980 Disease Relevance 0 Pain Relevance 1.24
In the present study, we demonstrated that repeated s.c. treatment with etorphine, but not morphine, produced a significant increase in protein levels of G protein-coupled receptor kinase 2, dynamin II, beta-arrestin 2 and phosphorylated-conventional protein kinase C in membranes of the mouse spinal cord, suggesting that the etorphine-induced mu-opioid receptor desensitization may result from G protein-coupled receptor kinase 2/dynaminII/beta-arrestin2-dependent phosphorylation of mu-opioid receptors.
Positive_regulation (increase) of dynamin II in spinal cord associated with kinase c, mu opioid receptor, opioid receptor, spinal cord, morphine and immobilon
8) Confidence 0.05 Published 2006 Journal Neuroscience Section Abstract Doc Link 16417975 Disease Relevance 0 Pain Relevance 1.01

General Comments

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