INT106603

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Context Info
Confidence 0.63
First Reported 2002
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 6.99
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (SKP2) cytosol (SKP2) nucleoplasm (SKP2)
SKP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 12 97.28 Very High Very High Very High
agonist 60 5.00 Very Low Very Low Very Low
Inflammation 50 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 232 99.72 Very High Very High Very High
Lymphatic System Cancer 244 99.60 Very High Very High Very High
Malignant Neoplastic Disease 16 96.72 Very High Very High Very High
Disease 50 96.32 Very High Very High Very High
Lung Cancer 1 92.92 High High
Hepatitis B Virus Infection 8 91.08 High High
Diffuse Large B-cell Lymphoma 112 88.48 High High
INFLAMMATION 61 88.12 High High
Hepatotoxicity 10 87.52 High High
Cervical Cancer 3 79.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoblotting and in vitro ubiquitination assays indicated that the expression of Cul1 and Skp2 and ubiquitination activity toward p27(Kip1) were not regulated by NSAIDs.
Gene_expression (expression) of Skp2 associated with cinod
1) Confidence 0.63 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435820 Disease Relevance 0.26 Pain Relevance 0.62
Skp2 overexpression is observed in
Gene_expression (overexpression) of Skp2
2) Confidence 0.29 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 1.24 Pain Relevance 0
The E3 ubiquitin ligase Skp2 is responsible for ubiquitination of the
Gene_expression (ligase) of Skp2
3) Confidence 0.26 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 1.22 Pain Relevance 0
The E3 ubiquitin ligase Skp2 is responsible for ubiquitination of the
Gene_expression (The) of Skp2
4) Confidence 0.26 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 1.23 Pain Relevance 0
Xiang-Lan analyzed the expression of Skp2 and p27 proteins in 48 cases of ENKL and found that the Skp2/p27 expression profile was an independent prognostic factor for overall survival in this highly malignant disease [70].


Spec (analyzed) Gene_expression (expression) of Skp2 associated with malignant neoplastic disease, lymphatic system cancer and disease
5) Confidence 0.21 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.55 Pain Relevance 0
Xiang-Lan analyzed the expression of Skp2 and p27 proteins in 48 cases of ENKL and found that the Skp2/p27 expression profile was an independent prognostic factor for overall survival in this highly malignant disease [70].


Gene_expression (expression) of Skp2 associated with malignant neoplastic disease, lymphatic system cancer and disease
6) Confidence 0.21 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.50 Pain Relevance 0

General Comments

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