INT106604

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Context Info
Confidence 0.90
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.24
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CIB1) cell adhesion (CIB1) endoplasmic reticulum (CIB1)
plasma membrane (CIB1) nucleus (CIB1) cytoplasm (CIB1)
CIB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 27 99.72 Very High Very High Very High
chemokine 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 3 96.44 Very High Very High Very High
INFLAMMATION 7 91.64 High High
Mantle-cell Lymphoma 33 89.08 High High
Apoptosis 5 65.28 Quite High
Lymphatic System Cancer 122 50.00 Quite Low
Cancer 41 47.76 Quite Low
Severe Combined Immunodeficiency 2 20.72 Low Low
Diffuse Large B-cell Lymphoma 56 8.96 Low Low
Epstein-barr Virus 30 5.00 Very Low Very Low Very Low
B-cell Lymphoma 27 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we elucidate the molecular mechanism by which NSAIDs modulate p27(Kip1) proteolysis.
Protein_catabolism (proteolysis) of Kip1 associated with cinod
1) Confidence 0.90 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435820 Disease Relevance 0.26 Pain Relevance 0.61
Collectively, our results revealed the mechanism by which NSAIDs modulate p27(Kip1) protein degradation and suggest that NSAIDs are a novel class of proteasome inhibitors.
Protein_catabolism (degradation) of Kip1 associated with cinod
2) Confidence 0.90 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435820 Disease Relevance 0.19 Pain Relevance 0.68
In vitro degradation experiments showed that p27(Kip1) degradation was inhibited by NS398, and the addition of purified 26S proteasome reversed this inhibitory effect.
Protein_catabolism (degradation) of Kip1
3) Confidence 0.90 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435820 Disease Relevance 0.21 Pain Relevance 0.69
These effects are mediated by nuclear accumulation of the p27(Kip1) inhibitor induced by the downregulation of the p45(Skp2) and Cks1 proteins, which target p27(Kip1) for degradation.
Protein_catabolism (degradation) of Kip1
4) Confidence 0.14 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.57 Pain Relevance 0

General Comments

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