INT106613

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.12
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (IFI27) molecular_function (IFI27)
Anatomy Link Frequency
bone marrow 1
placenta 1
IFI27 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 21 99.84 Very High Very High Very High
adenocard 1 57.48 Quite High
Inflammation 7 25.00 Low Low
palliative 1 25.00 Low Low
COX-2 inhibitor 9 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
pain pelvic 2 5.00 Very Low Very Low Very Low
endometriosis 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 76 99.76 Very High Very High Very High
Endometrial Cancer 9 98.00 Very High Very High Very High
Apoptosis 17 96.32 Very High Very High Very High
Metastasis 7 92.64 High High
Lung Cancer 47 90.40 High High
Breast Cancer 24 89.04 High High
Adenocarcinoma 1 87.96 High High
INFLAMMATION 10 85.60 High High
Carcinoma 5 74.72 Quite High
Adhesions 3 63.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For preparation of protein lysates from tissue samples (levator ani muscle; rectus fascia = ~negative control; and whole placenta = low p27 positive control) 100 tissue sections (7 ?
Regulation (control) of p27 in placenta
1) Confidence 0.57 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0 Pain Relevance 0
Immunoblotting and in vitro ubiquitination assays indicated that the expression of Cul1 and Skp2 and ubiquitination activity toward p27(Kip1) were not regulated by NSAIDs.
Neg (not) Regulation (regulated) of p27 associated with cinod
2) Confidence 0.42 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435820 Disease Relevance 0.25 Pain Relevance 0.63
The tumor suppressor p27 was not down-regulated in the present case.
Regulation (regulated) of p27 associated with cancer
3) Confidence 0.26 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1947947 Disease Relevance 1.39 Pain Relevance 0
Cyclins and the cyclin-dependent kinase inhibitors p21 and p27 are also regulated by proteasome-dependent proteolysis [4].
Regulation (regulated) of p27
4) Confidence 0.11 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234426 Disease Relevance 0.48 Pain Relevance 0.03
Interestingly, in Ist-Mes-1 and MPP89 no differences in p21 and p27 were observed, when compared to control (Figure 5).
Neg (no) Regulation (differences) of p27
5) Confidence 0.09 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.13 Pain Relevance 0
Other prognostic and predictive factors have been studied in an effort to explain this phenomenon, some of which are more relevant than others: HER-2/neu gene amplification and protein expression, expression of other members of the epithelial growth factor receptor family, S phase fraction, DNA ploidy, p53 gene mutations, cyclin E, p27 dysregulation, the presence of tumor cells in the circulation or bone marrow, and perineural and lymphovascular space invasion.
Regulation (dysregulation) of p27 in bone marrow associated with cancer
6) Confidence 0.02 Published 2007 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 17993229 Disease Relevance 0.86 Pain Relevance 0

General Comments

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