INT106618

Context Info Confidence 0.63 First Reported 2002 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 9 Total Number 9 Disease Relevance 3.38 Pain Relevance 3.63

nucleoplasm (CIB1) cell adhesion (CIB1) endoplasmic reticulum (CIB1) plasma membrane (CIB1) nucleus (CIB1) cytoplasm (CIB1)

Anatomy Link Frequency osteoblasts 1 lung 1 femurs 1 CIB1 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 39 100.00 Pain 22 100.00 aspirin 13 99.00 Inflammation 7 97.76 withdrawal 11 92.32 Cancer pain 4 88.08 dexamethasone 2 74.60 peptic ulcer disease 1 66.20 Inflammatory response 1 46.64 TRP channel 5 5.00

Disease Link Frequency Relevance Heat Pain 23 100.00 INFLAMMATION 26 99.98 Prostate Cancer 12 99.84 Nociception 11 97.84 Lung Cancer 3 97.00 Cancer Pain 2 88.08 Helminth Infection 14 86.72 Alagille Syndrome 2 84.92 Metastasis 6 84.80 Cancer 43 83.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We demonstrated previously that nonsteroidal anti-inflammatory drugs (NSAIDs) increased p27(Kip1) by inhibiting protein degradation to suppress the proliferation of human lung cancer cells.

Positive_regulation (increased) of Kip1 in lung associated with lung cancer, inflammation and cinod

1) Confidence 0.63 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435820 Disease Relevance 0.27 Pain Relevance 0.56

Mechanisms underlying nonsteroidal anti-inflammatory drug-induced p27(Kip1) expression.

Positive_regulation (drug-induced) of Kip1 associated with inflammation and cinod

2) Confidence 0.45 Published 2002 Journal Mol. Pharmacol. Section Title Doc Link 12435820 Disease Relevance 0.29 Pain Relevance 0.73

On the contrary, we found that NSAIDs inhibited proteasome activity to increase p27(Kip1) protein levels.

Positive_regulation (increase) of Kip1 associated with cinod

3) Confidence 0.45 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435820 Disease Relevance 0.24 Pain Relevance 0.68

Previous studies indicated that anti-inflammatory drugs up-regulated p27(Kip1), and this effect might play an important role in anti-inflammatory drug-induced cell cycle arrest of human osteoblasts (hOBs).

Positive_regulation (up-regulated) of Kip1 in osteoblasts associated with inflammation and cinod

4) Confidence 0.42 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 19883628 Disease Relevance 0.35 Pain Relevance 0.29

On the other hand, FOXO silencing significantly attenuated the drug-induced up-regulation of p27(Kip1) and suppression of proliferation in hOBs.

Positive_regulation (up-regulation) of Kip1

5) Confidence 0.42 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 19883628 Disease Relevance 0.44 Pain Relevance 0.47

The finding was associated to increased levels of some CDKIs, namely p27(Kip1) and p21(Cip1), whereas ASA did not affected p16(Ink4A) level at any of the concentrations employed.

Positive_regulation (increased) of Kip1 associated with aspirin

6) Confidence 0.40 Published 2008 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 19144277 Disease Relevance 0.13 Pain Relevance 0.51

IP3 independent activation of IP3Rs by proteins ligands such as CaBP (Ca2+ binding protein), CIB1 (Ca2+ and integrin binding 1, also known as calmyrin) and G-protein ??

Positive_regulation (activation) of CIB1

7) Confidence 0.13 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0.09 Pain Relevance 0

The cell cycle inhibition occurred concomitantly with an increase in p27(KIP1) protein levels, a reduction in Rb protein phosphorylation on serine residues 807-811, and a significant decrease in cyclin E-associated cdk2 activity.

Positive_regulation (increase) of KIP1

8) Confidence 0.10 Published 2002 Journal Exp. Cell Res. Section Abstract Doc Link 12441136 Disease Relevance 0.57 Pain Relevance 0.07

To our knowledge, this is the first study to provide a complete analysis of histological and radiographic results of rodent femurs combined with behavioral analysis in a model for CIBP induced by prostate cancer cell lines and via measurement of nociceptive scores.

Positive_regulation (induced) of CIBP in femurs associated with nociception, pain and prostate cancer

9) Confidence 0.09 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004636 Disease Relevance 1.01 Pain Relevance 0.33

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