INT106636

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Context Info
Confidence 0.28
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.06
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCA) mitochondrion (PRKCA) small molecule metabolic process (PRKCA)
endoplasmic reticulum (PRKCA) enzyme binding (PRKCA) cytoplasm (PRKCA)
Anatomy Link Frequency
neuronal 1
platelet 1
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 158 100.00 Very High Very High Very High
agonist 8 99.24 Very High Very High Very High
Inflammation 26 96.84 Very High Very High Very High
Glutamate receptor 6 93.60 High High
Central nervous system 20 93.36 High High
Dismenorea 1 93.08 High High
Paracetamol 3 84.76 Quite High
Serotonin 5 82.20 Quite High
Glutamate 1 77.72 Quite High
gABA 1 77.16 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 17 100.00 Very High Very High Very High
Virus Diseases 178 99.68 Very High Very High Very High
Apoptosis 7 97.84 Very High Very High Very High
Schizophrenia 100 97.04 Very High Very High Very High
INFLAMMATION 32 96.84 Very High Very High Very High
Infection 69 96.04 Very High Very High Very High
Ocular Hypertension 2 94.08 High High
Reprotox - General 1 2 93.08 High High
Disorder Of Lipid Metabolism 1 92.52 High High
Cirrhosis 1 91.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Role for protein kinase C delta in the functional activity of human UGT1A6: implications for drug-drug interactions between PKC inhibitors and UGT1A6.
PKC Binding (interactions) of associated with kinase c
1) Confidence 0.28 Published 2010 Journal Xenobiotica Section Title Doc Link 20196639 Disease Relevance 0 Pain Relevance 0.75
The S26/28A mutation of BDV P corrects the interference with PKC signaling
PKC Binding (interference) of associated with virus diseases and kinase c
2) Confidence 0.24 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.54 Pain Relevance 0.20
Recently, we showed that BDV selectively impairs neuronal plasticity through interfering with protein kinase C (PKC)–dependent signaling in neurons.
PKC Binding (interfering) of in neuronal associated with virus diseases and kinase c
3) Confidence 0.24 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673689 Disease Relevance 1.02 Pain Relevance 0.43
By immunoprecipitation and immunoblotting, we elucidated the phosphorylation pattern of green fluorescent protein-tagged AVP receptors and showed interactions with the specific kinases PKC and GRK5 that are agonist-, time- and receptor subtype-dependent.
PKC Binding (interactions) of associated with agonist
4) Confidence 0.16 Published 2002 Journal Prog. Brain Res. Section Abstract Doc Link 12436935 Disease Relevance 0.82 Pain Relevance 0.18
This is because, as PS-ODNS are more negatively charged as compared to phosphodiester ODNs, their polyanionic nature enhances their affinity for proteins, such as heparin-binding proteins, cell surface proteins, viral protein CD4, HIV glycoprotein 120, epidermal growth factor receptor (EGFR), platelet-derived growth factor (PDGF) and certain isoforms of protein kinase C (PKC), resulting in non-specific side effects.
PKC Binding (affinity) of in platelet associated with kinase c and acquired immune deficiency syndrome or hiv infection
5) Confidence 0.12 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 0.17 Pain Relevance 0.10
At least 12 different PKC isoforms have been characterized so far, and these can be grouped into the following three subgroups: conventional PKCs (?
PKC Binding (into) of
6) Confidence 0.10 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Moreover, we observed that those pathways were interlinked via PKC and AKT, suggesting their important roles in the molecular mechanisms of schizophrenia.
PKC Binding (interlinked) of associated with schizophrenia
7) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894047 Disease Relevance 0.51 Pain Relevance 0.26

General Comments

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