INT106638

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Context Info
Confidence 0.39
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.05
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (AVPR2) Golgi apparatus (AVPR2) endoplasmic reticulum (AVPR2)
plasma membrane (AVPR2) transmembrane transport (AVPR2) signal transducer activity (AVPR2)
Anatomy Link Frequency
heart 1
AVPR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 7 75.00 Quite High
Dismenorea 1 63.48 Quite High
depression 1 55.12 Quite High
Bioavailability 1 35.60 Quite Low
Glutamate 11 25.68 Quite Low
chemokine 7 5.00 Very Low Very Low Very Low
Cannabinoid receptor 2 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
Somatostatin 2 5.00 Very Low Very Low Very Low
Cannabinoid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Insipidus 1 98.44 Very High Very High Very High
Ocular Hypertension 2 98.16 Very High Very High Very High
Disease 6 98.04 Very High Very High Very High
Syndrome 2 97.20 Very High Very High Very High
Hyponatremia 2 94.88 High High
Cirrhosis 2 94.56 High High
Heart Rate Under Development 1 93.76 High High
Chondrodysplasia 1 93.16 High High
Hypercalcemia 2 88.28 High High
Pressure And Volume Under Development 1 87.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, V2 receptor blockade could be of interest in several water-retaining diseases such as the syndrome of inappropriate antidiuretic hormone secretion (SIADH), liver cirrhosis and congestive heart failure and deserves to be widely explored.
Negative_regulation (blockade) of V2 receptor in heart associated with hyponatremia, heart rate under development, cirrhosis, syndrome and disease
1) Confidence 0.39 Published 2002 Journal Prog. Brain Res. Section Abstract Doc Link 12436936 Disease Relevance 1.47 Pain Relevance 0.20
EST matches for CASR, PTHR1 and AVPR2 orthologs can be recovered in Ciona [Additional data file 2: Sheet 2].
Negative_regulation (recovered) of AVPR2
2) Confidence 0.27 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2396169 Disease Relevance 0.58 Pain Relevance 0

General Comments

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