INT106646

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 6.19
Pain Relevance 4.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Socs3) aging (Socs3) cytoplasm (Socs3)
Anatomy Link Frequency
blood cells 2
SH2 1
neuronal 1
Socs3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 409 100.00 Very High Very High Very High
ischemia 39 99.82 Very High Very High Very High
Inflammation 76 98.68 Very High Very High Very High
Ultiva 20 97.72 Very High Very High Very High
agonist 34 92.24 High High
anesthesia 14 89.16 High High
gABA 1 85.48 High High
Inflammatory response 7 79.92 Quite High
Central nervous system 1 76.16 Quite High
cerebral cortex 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 28 99.82 Very High Very High Very High
Sepsis 272 99.22 Very High Very High Very High
Middle Cerebral Artery Infarction 4 99.08 Very High Very High Very High
Necrosis 11 98.90 Very High Very High Very High
Reperfusion Injury 3 98.84 Very High Very High Very High
Cancer 11 98.72 Very High Very High Very High
INFLAMMATION 83 98.68 Very High Very High Very High
Death 39 97.12 Very High Very High Very High
Apoptosis 14 92.16 High High
Aids-related Complex 1 87.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antisense knockdown of ischemia-induced SOCS-3 protein expression exacerbated transient MCAO-induced infarct volume assigning a neuroprotective role to SOCS-3, a gene not heretofore implicated in ischemic neuronal damage.
Gene_expression (expression) of SOCS-3 in neuronal associated with middle cerebral artery infarction and ischemia
1) Confidence 0.69 Published 2002 Journal J. Neurochem. Section Abstract Doc Link 12437578 Disease Relevance 0.96 Pain Relevance 0.50
In addition, the increased expression of Nur77 and SOCS3 could be part of a broader anti-inflammatory effect.
Gene_expression (expression) of SOCS3 associated with inflammation
2) Confidence 0.65 Published 2010 Journal Peptides Section Abstract Doc Link 19799952 Disease Relevance 0.20 Pain Relevance 0.20
Hepatic mRNA of CIS, SOCS-2 and SOCS-3 is transiently increased following endotoxin administration [31], while SOCS-1 expression and SOCS-3 expression were found to be increased 24 hours following CLP [14].
Gene_expression (expression) of SOCS-3
3) Confidence 0.34 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.41 Pain Relevance 0.12
We now demonstrate continued induction of SOCS-3 expression at 72 hours after CLP, associated with reduced hepatic expression of mRNA of IGF-I and reduced serum IGF-I concentrations.
Gene_expression (expression) of SOCS-3
4) Confidence 0.34 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.46 Pain Relevance 0.12
We found greater SOCS-3 expression with PN compared with EN in sepsis, whereas in sham-operated animals the SOCS-3 expression was lowest in those given PN.
Gene_expression (expression) of SOCS-3 associated with sepsis
5) Confidence 0.34 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.54 Pain Relevance 0.12
SOCS-1 and CIS expression were increased 4 hours following induction of sepsis, but by 24 hours were no different from measurements in sham-operated animals – whereas SOCS-3 expression remained elevated at 24 hours.
Gene_expression (expression) of SOCS-3 associated with sepsis
6) Confidence 0.34 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.42 Pain Relevance 0.12
We found greater SOCS-3 expression with PN compared with EN in sepsis, whereas in sham-operated animals the SOCS-3 expression was lowest in those given PN.
Gene_expression (expression) of SOCS-3 associated with sepsis
7) Confidence 0.34 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.54 Pain Relevance 0.10
In addition, caloric restricted animals showed decreased expression levels of insulin receptor, and higher expression of SOCS-3 after weaning, suggesting that these animals were programmed for a lower sensitivity to insulin [12].
Gene_expression (expression) of SOCS-3
8) Confidence 0.27 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.43 Pain Relevance 0.04
Hepatic expression of mRNA for CIS, SOCS-2, SOCS-3, IGF-I and GHR
Gene_expression (expression) of SOCS-3
9) Confidence 0.27 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.08 Pain Relevance 0.17
Serum levels of IL-6 and IL-10 were measured by immunoassay, and hepatic expressions of cytokine-inducible SH2-containing protein, SOCS-2, SOCS-3, IGF-I and the growth hormone receptor (GHR) were measured by real-time quantitative PCR.


Gene_expression (expressions) of SOCS-3 in SH2 associated with cytokine
10) Confidence 0.27 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2206515 Disease Relevance 0.28 Pain Relevance 0.25
, whereas those of SOCS3 did not (Fig. 6B).
Gene_expression (those) of SOCS3
11) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.42 Pain Relevance 0.30
and others demonstrated that rosiglitazone and 15dPGJ2 induce SOCS3 expression
Gene_expression (expression) of SOCS3
12) Confidence 0.18 Published 2008 Journal PPAR Research Section Body Doc Link PMC2293414 Disease Relevance 0.48 Pain Relevance 0.36
The IFN-gamma/IL-10 ratio after concanavalin A stimulation in whole blood cells on post-operative day 1 and SOCS-3 gene expression on post-operative day 2 were significantly lower in the remifentanil group than in the fentanyl group.
Gene_expression (expression) of SOCS-3 in blood cells associated with ultiva
13) Confidence 0.10 Published 2008 Journal J. Int. Med. Res. Section Abstract Doc Link 19094432 Disease Relevance 0.26 Pain Relevance 0.68
Levels of interleukin (IL)-6, IL-10, tumour necrosis factor-alpha and interferon-gamma (IFN-gamma) and the expression of SOCS-3 were measured pre- and post-operatively.
Gene_expression (expression) of SOCS-3 associated with necrosis and cancer
14) Confidence 0.10 Published 2008 Journal J. Int. Med. Res. Section Abstract Doc Link 19094432 Disease Relevance 0.26 Pain Relevance 0.57
/IL-10 ratio after Con-A stimulation in whole blood cells on post-operative day 1, and SOCS-3 gene expression on post-operative day 2 were significantly lower in the remifentanil group than in the fentanyl group.
Gene_expression (expression) of SOCS-3 in blood cells associated with ultiva
15) Confidence 0.05 Published 2010 Journal Crit Care Section Body Doc Link PMC2887136 Disease Relevance 0.46 Pain Relevance 0.65

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