INT106647

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Context Info
Confidence 0.38
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.42
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Socs3) aging (Socs3) cytoplasm (Socs3)
Anatomy Link Frequency
neuronal 2
Socs3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 5 100.00 Very High Very High Very High
cytokine 2 99.24 Very High Very High Very High
Inflammation 2 98.28 Very High Very High Very High
gABA 1 86.68 High High
Central nervous system 1 78.84 Quite High
cerebral cortex 2 75.00 Quite High
Neurotransmitter 1 64.32 Quite High
anesthesia 3 48.48 Quite Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 4 100.00 Very High Very High Very High
Middle Cerebral Artery Infarction 4 99.08 Very High Very High Very High
INFLAMMATION 2 98.28 Very High Very High Very High
Aids-related Complex 1 89.76 High High
Insulin Resistance 9 85.84 High High
Hypertension 3 75.00 Quite High
Brain Hemorrhage 1 75.00 Quite High
Hyperphagia 6 72.84 Quite High
Overweight 1 69.44 Quite High
Hyperinsulinism 4 61.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antisense knockdown of ischemia-induced SOCS-3 protein expression exacerbated transient MCAO-induced infarct volume assigning a neuroprotective role to SOCS-3, a gene not heretofore implicated in ischemic neuronal damage.
Negative_regulation (knockdown) of Gene_expression (expression) of SOCS-3 in neuronal associated with middle cerebral artery infarction and ischemia
1) Confidence 0.38 Published 2002 Journal J. Neurochem. Section Abstract Doc Link 12437578 Disease Relevance 0.97 Pain Relevance 0.51
In addition, caloric restricted animals showed decreased expression levels of insulin receptor, and higher expression of SOCS-3 after weaning, suggesting that these animals were programmed for a lower sensitivity to insulin [12].
Negative_regulation (showed) of Gene_expression (expression) of SOCS-3
2) Confidence 0.15 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.45 Pain Relevance 0.04

General Comments

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