INT106649

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Context Info
Confidence 0.62
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.04
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Socs3) aging (Socs3) cytoplasm (Socs3)
Anatomy Link Frequency
neuronal 2
Socs3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 7 99.98 Very High Very High Very High
Inflammation 7 98.68 Very High Very High Very High
cytokine 110 98.36 Very High Very High Very High
gABA 1 85.80 High High
cerebral cortex 2 75.00 Quite High
melanocortin 1 receptor 1 70.96 Quite High
Neurotransmitter 1 63.44 Quite High
anesthesia 3 47.60 Quite Low
agonist 1 40.44 Quite Low
analgesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 4 99.98 Very High Very High Very High
Reperfusion Injury 2 99.24 Very High Very High Very High
Middle Cerebral Artery Infarction 4 99.08 Very High Very High Very High
INFLAMMATION 7 98.68 Very High Very High Very High
Sepsis 74 98.22 Very High Very High Very High
Brain Hemorrhage 1 75.00 Quite High
Hypertension 1 75.00 Quite High
Stress 1 59.00 Quite High
Stroke 1 46.28 Quite Low
Death 1 44.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antisense knockdown of ischemia-induced SOCS-3 protein expression exacerbated transient MCAO-induced infarct volume assigning a neuroprotective role to SOCS-3, a gene not heretofore implicated in ischemic neuronal damage.
Positive_regulation (induced) of Gene_expression (expression) of SOCS-3 in neuronal associated with middle cerebral artery infarction and ischemia
1) Confidence 0.62 Published 2002 Journal J. Neurochem. Section Abstract Doc Link 12437578 Disease Relevance 0.96 Pain Relevance 0.50
In addition, the increased expression of Nur77 and SOCS3 could be part of a broader anti-inflammatory effect.
Positive_regulation (increased) of Gene_expression (expression) of SOCS3 associated with inflammation
2) Confidence 0.58 Published 2010 Journal Peptides Section Abstract Doc Link 19799952 Disease Relevance 0.20 Pain Relevance 0.20
We now demonstrate continued induction of SOCS-3 expression at 72 hours after CLP, associated with reduced hepatic expression of mRNA of IGF-I and reduced serum IGF-I concentrations.
Positive_regulation (induction) of Gene_expression (expression) of SOCS-3
3) Confidence 0.31 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.46 Pain Relevance 0.12
SOCS-1 and CIS expression were increased 4 hours following induction of sepsis, but by 24 hours were no different from measurements in sham-operated animals – whereas SOCS-3 expression remained elevated at 24 hours.
Positive_regulation (elevated) of Gene_expression (expression) of SOCS-3 associated with sepsis
4) Confidence 0.21 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.43 Pain Relevance 0.12

General Comments

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