INT106667

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 9.96
Pain Relevance 5.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NDRG1) plasma membrane (NDRG1) nucleus (NDRG1)
cytoplasm (NDRG1)
Anatomy Link Frequency
neurons 6
neuronal 1
sciatic nerve 1
pancreas 1
Caco-2 1
NDRG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 40 100.00 Very High Very High Very High
sodium channel 9 100.00 Very High Very High Very High
nav1.8 9 100.00 Very High Very High Very High
calcitonin gene related peptide 24 99.84 Very High Very High Very High
Enkephalin 37 99.78 Very High Very High Very High
Congenital analgesia 3 99.44 Very High Very High Very High
Sciatic nerve 73 98.96 Very High Very High Very High
qutenza 125 98.14 Very High Very High Very High
c fibre 22 97.84 Very High Very High Very High
agonist 71 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 205 100.00 Very High Very High Very High
Colon Cancer 26 100.00 Very High Very High Very High
Metastasis 11 100.00 Very High Very High Very High
Congenital Pain Insensitivity 3 99.44 Very High Very High Very High
Cold Sores 109 99.32 Very High Very High Very High
Breast Cancer 229 98.78 Very High Very High Very High
Nervous System Injury 32 98.64 Very High Very High Very High
Colorectal Cancer 3 98.16 Very High Very High Very High
Injury 46 97.64 Very High Very High Very High
Nociception 31 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Caco-2 cells, the differentiation-related gene NDRG1, which is expressed during differentiation and down-regulated in colorectal neoplasms [62], was up-regulated at 12 hrs.
Gene_expression (expressed) of NDRG1 in Caco-2 associated with colorectal cancer
1) Confidence 0.70 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.40 Pain Relevance 0
WalBC cells also over expressed the tumor metastasis suppressor NDRG1, which has been shown to be negatively correlated with tumor metastasis.
Gene_expression (expressed) of NDRG1 associated with metastasis
2) Confidence 0.46 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2263075 Disease Relevance 0.97 Pain Relevance 0
In vitro and in vivo studies have also demonstrated a significant reduction in the metastatic ability of cells over-expressing NDRG1[48].
Gene_expression (expressing) of NDRG1
3) Confidence 0.40 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2263075 Disease Relevance 0.85 Pain Relevance 0
WalBC cells exhibited expression of known markers of basal invasive human breast cancers as well as increased KRT17, KRT 14 and KRT 19, DSP, s100A4, NDRG-1, ANXA1, TK1 and AQP3 gene expression and decreased gene expression of TIMP3, VIM and TAGLN.
Gene_expression (expression) of NDRG-1 associated with breast cancer
4) Confidence 0.35 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2263075 Disease Relevance 0.81 Pain Relevance 0
Notably WalBC cells showed up regulated expression of DSP, s100A4, ANXA1, NDRG-1, TK1 and down regulation of genes such as tissue inhibitor of TIMP-3 and TAGLN.
Gene_expression (expression) of NDRG-1
5) Confidence 0.35 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2263075 Disease Relevance 0.40 Pain Relevance 0
We also show that ranolazine, at a clinically-relevant concentration, blocks high-frequency firing of DRG neurons expressing wild-type but not mutant channels.
Gene_expression (expressing) of DRG in neurons
6) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link 20529343 Disease Relevance 0 Pain Relevance 0
Expression of sodium channel Nav1.8 in DRG neurons has also been shown to be essential for the manifestation of mutant Nav1.7-induced neuronal hyperexcitability.
Gene_expression (Expression) of DRG in neuronal associated with sodium channel, nav1.8, hyperexcitability and nav1.7
7) Confidence 0.13 Published 2010 Journal Mol Pain Section Abstract Doc Link 20529343 Disease Relevance 0.64 Pain Relevance 1.39
CONCLUSIONS: Our data suggest that ranalozine can attenuate hyperexcitability of DRG neurons over-expressing wild-type Nav1.7 channels, as occurs in acquired neuropathic and inflammatory pain, and thus merits further study as an alternative to existing non-selective sodium channel blockers.


Gene_expression (expressing) of DRG in neurons
8) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link 20529343 Disease Relevance 0 Pain Relevance 0
Drg-1 (differentiation-related gene-1), a putative suppressor gene in human colorectal cancer, and PTEN, a tumor suppressor gene which modulates several cellular functions, including cell migration, survival, and proliferation, were found to be controlled at least in part by PPAR?
Gene_expression (found) of Drg-1 associated with cancer and colon cancer
9) Confidence 0.13 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 1.04 Pain Relevance 0.12
Previous studies with comparable means demonstrated that a minor fraction of keratinocytes may exhibit a CAP-induced fluorometric Ca2+ influx signal similar to that demonstrated by one of us in TRPV1+ DRG neurons.
Gene_expression (neurons) of DRG in neurons associated with qutenza
10) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566593 Disease Relevance 0 Pain Relevance 0.39
On the other hand, a HaCaT cell line established to express TRPV1 ectopically and primary DRG culture readily showed 45Ca2+ influx upon challenge with these agonists.
Gene_expression (express) of DRG associated with agonist
11) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566593 Disease Relevance 0.32 Pain Relevance 0.51
Delivery of recombinant viruses to the skin of mice results in expression of encoded complementary DNA (cDNA) genes in DRG neurons within three to four days.
Gene_expression (expression) of DRG in neurons
12) Confidence 0.02 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12438172 Disease Relevance 0.42 Pain Relevance 0.50
However, there was a significant expression of caspase-3 in 25.3% of cells ipsilateral to treatment as compared to no significant expression in contralateral DRG or in sham DRG (Fig. 7A, c and Table 2).
Neg (no) Gene_expression (expression) of DRG
13) Confidence 0.01 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.47 Pain Relevance 0.15
Similar to ATF3 expression in sections from the same DRG, the majority of caspase-3 cells were small diameter C-fibre neurons as determined by NF-200 immunostaining.
Gene_expression (expression) of DRG in neurons associated with c fibre
14) Confidence 0.01 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.42 Pain Relevance 0.16
At the time of peak behavioural change we found no change in DRG expression of CGRP or TRPV1.
Gene_expression (expression) of DRG associated with calcitonin gene related peptide
15) Confidence 0.01 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 1.19 Pain Relevance 0.39
Therefore, as a positive control we assessed expression levels of GAP-43-IR in the ipsilateral DRG 7 days following partial sciatic nerve injury of the sciatic nerve (Seltzer et al., 1990).
Gene_expression (expression) of DRG in sciatic nerve associated with nervous system injury and sciatic nerve
16) Confidence 0.01 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.57 Pain Relevance 0.22
TRPA1 is colocalized with 30% - 50% TRPV1 expressing neurons in rodent [43] and human DRG, where the expression of both channels is increased after injury [44].
Gene_expression (expressing) of DRG in neurons associated with injury
17) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC3003244 Disease Relevance 0.66 Pain Relevance 0.75
Increased met-Enkephalin (met-ENK) expression in spinal cord, DRG and pancreas in HSV-ENK-treated animals
Gene_expression (expression) of DRG in pancreas associated with cold sores, enkephalin and spinal cord
18) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2292157 Disease Relevance 0.81 Pain Relevance 0.57

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