INT10668

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Context Info
Confidence 0.69
First Reported 1986
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 61
Total Number 63
Disease Relevance 15.21
Pain Relevance 52.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Anatomy Link Frequency
Ovary 8
NG108-15 6
immune cells 6
hypothalamus 5
peripheral neurons 4
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 1515 100.00 Very High Very High Very High
Opioid 1400 100.00 Very High Very High Very High
Inflammation 747 100.00 Very High Very High Very High
Pain 418 100.00 Very High Very High Very High
Endogenous opioid 399 100.00 Very High Very High Very High
agonist 282 100.00 Very High Very High Very High
antagonist 154 100.00 Very High Very High Very High
MU agonist 148 100.00 Very High Very High Very High
narcan 103 100.00 Very High Very High Very High
cytokine 93 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 417 100.00 Very High Very High Very High
INFLAMMATION 799 99.98 Very High Very High Very High
Neuropathic Pain 63 99.80 Very High Very High Very High
Targeted Disruption 36 99.78 Very High Very High Very High
Glioma 6 99.64 Very High Very High Very High
Pruritus 9 99.28 Very High Very High Very High
Inflammatory Pain 72 99.04 Very High Very High Very High
Drug Dependence 4 98.56 Very High Very High Very High
Nervous System Injury 7 98.44 Very High Very High Very High
Sepsis 151 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present data suggested that the central, but not peripheral, plasticity triggered by inflammation-induced facilitation of A(beta) fibers plays an important role in morphine-induced alleviation of allodynia, whereas activation of opioid receptor expression on the peripheral terminals of C fibers may contribute to morphine-induced alleviation of persistent pain of inflammation.
Positive_regulation (activation) of Gene_expression (expression) of opioid receptor associated with pain, allodynia, inflammation, lasting pain, opioid receptor and morphine
1) Confidence 0.69 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14642787 Disease Relevance 0.76 Pain Relevance 1.14
Inflammation not only increases the opioid receptor expression in DRG neurons but also enhances transport and accumulation of opioid receptors on the peripheral terminals of sensory neurons.
Positive_regulation (increases) of Gene_expression (expression) of opioid receptor in sensory neurons associated with inflammation and opioid receptor
2) Confidence 0.65 Published 2003 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 12617566 Disease Relevance 0.34 Pain Relevance 0.87
NaCl increased its affinity by about 4-fold in membranes of rat brain and Chinese Hamster Ovary Cells stably transfected with the human delta-opioid receptors (hDOR-CHO) showing that the new ligand is an antagonist.
Positive_regulation (increased) of Gene_expression (transfected) of delta-opioid in Ovary associated with antagonist and delta opioid receptors
3) Confidence 0.49 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18068762 Disease Relevance 0.31 Pain Relevance 0.30
NaCl increased its affinity by about 4-fold in membranes of rat brain and Chinese Hamster Ovary Cells stably transfected with the human delta-opioid receptors (hDOR-CHO) showing that the new ligand is an antagonist.
Positive_regulation (transfected) of Gene_expression (transfected) of delta-opioid in Ovary associated with antagonist and delta opioid receptors
4) Confidence 0.49 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18068762 Disease Relevance 0.30 Pain Relevance 0.30
Intense expression of mu-opioid receptor mRNA was observed in the internal granular and glomerular layers of the olfactory bulb, caudate putamen, nucleus accumbens, medial septum, diagonal band, medial preoptic area, several nuclei of thalamus, amygdala, interpeduncular nucleus, medial raphe nucleus, inferior colliculus, parabrachial nucleus, locus coeruleus, nucleus solitary tract and ambiguus nucleus.
Positive_regulation (Intense) of Gene_expression (expression) of mu-opioid receptor mRNA in preoptic area associated with locus ceruleus, thalamus, opioid receptor, parabrachial, nucleus accumbens, urological neuroanatomy, amygdala and raphe
5) Confidence 0.44 Published 1994 Journal Neurosci. Res. Section Abstract Doc Link 8190373 Disease Relevance 0.09 Pain Relevance 0.94
These results strongly suggest that cotransfection of mu- and delta-opioid receptors alters the binding and functional characteristics of the receptors.
Positive_regulation (cotransfection) of Gene_expression (cotransfection) of delta-opioid associated with delta opioid receptors
6) Confidence 0.43 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11259622 Disease Relevance 0 Pain Relevance 0.89
Importantly, during this treatment the mRNA expression of all three opioid receptors (MOR1, KOR1 and DOR1) was increased as assessed by real-time RTPCR though subsequent western blot analysis revealed a selective increase in the protein level of DOR1, only.
Positive_regulation (increased) of Gene_expression (expression) of DOR1 associated with opioid receptor
7) Confidence 0.41 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19560378 Disease Relevance 0 Pain Relevance 1.12
Northern blot analysis showed that expression of mu-opioid receptor mRNA was intensive in the thalamus, striatum, hypothalamus and pons-medulla, moderate in the hippocampus and midbrain, and slight in the cerebral cortex and cerebellum.
Positive_regulation (intensive) of Gene_expression (expression) of mu-opioid receptor mRNA in hypothalamus associated with medulla, midbrain, hippocampus, thalamus, opioid receptor and cerebral cortex
8) Confidence 0.41 Published 1994 Journal Neurosci. Res. Section Abstract Doc Link 8190373 Disease Relevance 0.06 Pain Relevance 0.82
To study the mechanism of this receptor modulation we have employed CHO cells containing a single, transfected opioid receptor of the delta-type.
Positive_regulation (transfected) of Gene_expression (transfected) of opioid receptor associated with opioid receptor
9) Confidence 0.38 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9073176 Disease Relevance 0.17 Pain Relevance 0.36
Evidence that weaning stimulates the developmental expression of a delta-opioid receptor subtype in the rat.
Positive_regulation (stimulates) of Gene_expression (expression) of delta-opioid receptor associated with analgesic and opioid receptor
10) Confidence 0.37 Published 1994 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 8004769 Disease Relevance 0 Pain Relevance 0.52
The levels of this biologically active K opioid receptor agonist significantly increased after 4 h of KCl treatment and were markedly reduced following a 24-h exposure of the cardiac myocytes to KCl.
Positive_regulation (increased) of Gene_expression (levels) of K opioid receptor in cardiac myocytes associated with agonist and opioid receptor
11) Confidence 0.37 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 7906274 Disease Relevance 0 Pain Relevance 0.46
These data imply that specific regulatory processes that include stimulation of opioid gene expression are strongly engaged in the spinal cord in certain types of peripheral nerve injuries and inflammation, but not in others.
Positive_regulation (stimulation) of Gene_expression (expression) of opioid gene in spinal cord associated with nervous system injury, inflammation, opioid and spinal cord
12) Confidence 0.32 Published 1991 Journal Brain Res. Section Abstract Doc Link 1684729 Disease Relevance 0.73 Pain Relevance 1.15
Activation of HEK293 cells, stably expressing the micro-opioid receptor with micro-opioid agonists results in the transcriptional activation of a STAT-responsive reporter gene.
Positive_regulation (results) of Gene_expression (expressing) of opioid receptor associated with mu agonist and opioid receptor
13) Confidence 0.32 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15857395 Disease Relevance 0.09 Pain Relevance 0.61
The opioid receptor antagonists used were as follows: µ opioid receptor antagonist, CTOP (15 µg); ?
Positive_regulation (follows) of Gene_expression (antagonist) of opioid receptor associated with antagonist and opioid receptor
14) Confidence 0.30 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC3000619 Disease Relevance 0.06 Pain Relevance 0.75
For this purpose we transfected HEK-293 cells with rat delta-opioid receptor (DOR).
Positive_regulation (transfected) of Gene_expression (transfected) of opioid receptor associated with opioid receptor
15) Confidence 0.30 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11731019 Disease Relevance 0 Pain Relevance 0.49
To evaluate the potential of this system, we chose a series of (-)-5,9 alpha-dimethyl-2-hydroxy-N-substituted-6,7-benzomorphans, for which the receptor selectivity and in vivo activity had been characterized recently, and tested them in CHO cells stably transfected with either the rat delta-opioid receptor or the mouse mu-opioid receptor. [3H]Diprenorphine was used to measure opioid receptors in P2 membrane preparations.
Positive_regulation (transfected) of Gene_expression (transfected) of delta-opioid receptor in CHO associated with opioid receptor
16) Confidence 0.24 Published 1995 Journal Biochem. Pharmacol. Section Abstract Doc Link 7575648 Disease Relevance 0 Pain Relevance 0.33
Up-regulation of opioid gene expression in spinal cord evoked by experimental nerve injuries and inflammation.
Positive_regulation (Up-regulation) of Gene_expression (expression) of opioid gene in spinal cord associated with nervous system injury, inflammation, opioid and spinal cord
17) Confidence 0.23 Published 1991 Journal Brain Res. Section Title Doc Link 1684729 Disease Relevance 0.71 Pain Relevance 1.09
A C6 glioma cell line stably transfected with the rat delta opioid receptor (C6delta) was used to characterize receptor binding and G protein activation by both peptide and nonpeptide delta opioid ligands.
Positive_regulation (transfected) of Gene_expression (transfected) of delta opioid receptor associated with opioid receptor, opioid and glioma
18) Confidence 0.23 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353363 Disease Relevance 0.17 Pain Relevance 0.47
Delta opioid receptor mRNA expression is changed in the thalamus and brainstem of monoarthritic rats.
Positive_regulation (changed) of Gene_expression (expression) of Delta opioid receptor mRNA in thalamus associated with medulla, thalamus and opioid receptor
19) Confidence 0.20 Published 2008 Journal J. Chem. Neuroanat. Section Title Doc Link 18572383 Disease Relevance 0.39 Pain Relevance 0.81
Taken together, the changes that occur during inflammation contribute to enhanced opioid receptor expression and efficacy, particularly for MOR.


Positive_regulation (enhanced) of Gene_expression (expression) of opioid receptor associated with inflammation and opioid receptor
20) Confidence 0.19 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.49 Pain Relevance 1.76

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