INT106690

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Context Info
Confidence 0.61
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.12
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SIGMAR1) nuclear envelope (SIGMAR1) lipid particle (SIGMAR1)
endoplasmic reticulum (SIGMAR1) plasma membrane (SIGMAR1) nucleus (SIGMAR1)
Anatomy Link Frequency
reticulum 4
spinal cord dorsal horn 2
neurite 2
SIGMAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 8 98.60 Very High Very High Very High
fortral 5 94.24 High High
agonist 2 88.12 High High
antagonist 3 82.28 Quite High
antidepressant 6 75.00 Quite High
cocaine 3 53.64 Quite High
Neuropathic pain 2 50.00 Quite Low
intrathecal 2 50.00 Quite Low
allodynia 1 50.00 Quite Low
addiction 2 45.44 Quite Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 3 63.20 Quite High
Nociception 1 56.76 Quite High
Drug Dependence 2 45.44 Quite Low
Depression 2 44.60 Quite Low
Schizophrenia 2 44.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have successfully reconstituted this hypothetical model in HEK-293 cells overexpressing both the sigma1 receptor and sphingosine kinase-1.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of sigma1 receptor
1) Confidence 0.61 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19285059 Disease Relevance 0 Pain Relevance 0.10
Indeed, the overexpression of Sig-1R per se in PC12 cells enhanced the NGF-induced neurite sprouting.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Sig-1R in neurite associated with nerve growth factor
2) Confidence 0.36 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12438547 Disease Relevance 0 Pain Relevance 0.73
Sig-1R expression significantly increased in the ipsilateral spinal cord dorsal horn from days 1 to 3 after CCI.
Positive_regulation (increased) of Gene_expression (expression) of Sig-1R in spinal cord dorsal horn
3) Confidence 0.27 Published 2008 Journal Anesthesiology Section Body Doc Link 18946301 Disease Relevance 0.12 Pain Relevance 0
EYFP-Sig-1R-transfected cells showed an unrestricted distribution of neutral lipids all over the endoplasmic reticulum network, decreases in c-LDs and cholesterol in plasma membranes, and the bulbous aggregation of endoplasmic reticulum.
Positive_regulation (transfected) of Gene_expression (transfected) of EYFP-Sig-1R in reticulum
4) Confidence 0.00 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12730355 Disease Relevance 0 Pain Relevance 0.09
EYFP-Sig-1R-transfected cells showed an unrestricted distribution of neutral lipids all over the endoplasmic reticulum network, decreases in c-LDs and cholesterol in plasma membranes, and the bulbous aggregation of endoplasmic reticulum.
Positive_regulation (transfected) of Gene_expression (transfected) of EYFP-Sig-1R in reticulum
5) Confidence 0.00 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12730355 Disease Relevance 0 Pain Relevance 0.09

General Comments

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