INT106709

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Context Info
Confidence 0.06
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 4.89
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (LAMB2) cell adhesion (LAMB2) structural molecule activity (LAMB2)
Anatomy Link Frequency
neurons 2
plasma 1
keratinocyte 1
neurite 1
LAMB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 15 93.12 High High
Spinal cord 10 86.44 High High
midbrain 2 85.76 High High
imagery 14 85.44 High High
Central nervous system 35 79.76 Quite High
Neuritis 8 56.92 Quite High
Multiple sclerosis 6 53.76 Quite High
GABAergic 5 48.72 Quite Low
metalloproteinase 5 47.76 Quite Low
alcohol 5 37.44 Quite Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 23 99.32 Very High Very High Very High
Leptospirosis 87 98.96 Very High Very High Very High
Cancer 128 98.92 Very High Very High Very High
Fibrosarcoma 8 96.76 Very High Very High Very High
Carcinoma 8 96.04 Very High Very High Very High
Injury 73 95.78 Very High Very High Very High
Neuromyelitis Optica 57 94.20 High High
Skin Cancer 11 92.08 High High
Wound Healing 16 91.00 High High
Adhesions 36 90.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, binding to fibronectin was significantly reduced by alphaMSH in the wild type transfectants whereas this was not observed in the variant transfected clones; binding to laminin was not affected by alphaMSH in this cell line.
laminin Binding (binding) of
1) Confidence 0.06 Published 2002 Journal Oncogene Section Abstract Doc Link 12439754 Disease Relevance 0.70 Pain Relevance 0.93
To examine the effects of laminin concentrations on hESC-derived neurogenesis, we systematically measured neural progenitor expansion and total neurite length per neuron at 5 laminin coating concentrations: 1 ?
laminin Binding (concentrations) of in neurite associated with neurodegenerative disease
2) Confidence 0.05 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570688 Disease Relevance 0.22 Pain Relevance 0
Neurite outgrowth of hESC-derived neurons is greater on laminin and laminin-rich matrigel
laminin Binding (greater) of in neurons
3) Confidence 0.05 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570688 Disease Relevance 0 Pain Relevance 0
Neurite outgrowth of hESC-derived neurons is greater on laminin and laminin-rich matrigel
laminin Binding (greater) of in neurons
4) Confidence 0.05 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570688 Disease Relevance 0 Pain Relevance 0
Ours and other studies indicate laminin interactions with ?
laminin Binding (interactions) of
5) Confidence 0.05 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570688 Disease Relevance 0 Pain Relevance 0.04
6, clone NKI-GoH3 is well characterized antibody which has been used to inhibit laminin binding [21,22].
laminin Binding (binding) of
6) Confidence 0.05 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570688 Disease Relevance 0.18 Pain Relevance 0
Laminin oxidation by sodium metaperiodate reduced the protein-laminin interaction in a concentration-dependent manner, indicating that laminin sugar moieties are crucial for this interaction.
laminin Binding (interaction) of
7) Confidence 0.02 Published 2008 Journal BMC Microbiol Section Abstract Doc Link PMC2386478 Disease Relevance 0.52 Pain Relevance 0
A stronger interaction was observed with laminin, collagen IV and plasma fibronectin.
laminin Binding (interaction) of in plasma
8) Confidence 0.02 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2386478 Disease Relevance 0.41 Pain Relevance 0
The outer membrane protein YadA of Yersinia enterocolitica has been shown to bind to laminin, fibronectin, and several types of collagens [41-43].
laminin Binding (bind) of
9) Confidence 0.02 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2386478 Disease Relevance 0.17 Pain Relevance 0
Importantly, a trimerbody that recognizes an angiogenesis-associated laminin epitope, showed excellent tumor localization in several cancer types, including fibrosarcomas and carcinomas.
laminin Binding (recognizes) of associated with fibrosarcoma, cancer and carcinoma
10) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2670539 Disease Relevance 0.81 Pain Relevance 0.08
Trimerbodies were then tested for their capability to retain functional binding to murine laminin by ELISA.


laminin Binding (binding) of
11) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670539 Disease Relevance 0 Pain Relevance 0
In the wound area, keratinocytes come in contact with the newly exposed dermal matrix, which contains Type I collagen and laminin 5 not found in the intact keratinocyte basement membrane, typically composed of collagen IV, laminin 1, fibronectin, and other molecules.8,9 The newly exposed dermal matrix components bind and activate the ?
laminin Neg (not) Binding (bind) of in keratinocyte associated with injury
12) Confidence 0.00 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501117 Disease Relevance 0.91 Pain Relevance 0
Moreover, its partial colocalization with laminin [54] is consistent with the auto-antigen being a component of the glia limitans at the BBB [66].
laminin Spec (partial) Binding (colocalization) of
13) Confidence 0.00 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.97 Pain Relevance 0.21

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