INT106718

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.70
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
NAc 2
endothelial cells 2
neurons 2
brain 2
cingulate cortex 2
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 12 100.00 Very High Very High Very High
Anterior cingulate cortex 32 99.86 Very High Very High Very High
Nucleus accumbens 15 99.68 Very High Very High Very High
Ventral tegmentum 5 99.36 Very High Very High Very High
addiction 39 97.52 Very High Very High Very High
allodynia 2 95.28 Very High Very High Very High
Opioid 1 93.84 High High
Inflammatory stimuli 1 93.40 High High
Morphine 7 91.96 High High
cocaine 7 91.20 High High
Disease Link Frequency Relevance Heat
Stress 106 100.00 Very High Very High Very High
INFLAMMATION 21 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 137 99.36 Very High Very High Very High
Anxiety Disorder 143 99.28 Very High Very High Very High
Targeted Disruption 67 96.64 Very High Very High Very High
Neuropathic Pain 2 95.28 Very High Very High Very High
Frailty 3 93.40 High High
Pain 6 90.12 High High
Drug Dependence 8 84.56 Quite High
Disease 8 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consequently, the 90% reduction of CREB in CREBalphaDelta mutant mice differentially affects CREB phosphorylation and induction of downstream targets of CREB in the NAc and VTA.
Regulation (affects) of Positive_regulation (induction) of CREB in NAc associated with ventral tegmentum and nucleus accumbens
1) Confidence 0.45 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 14622103 Disease Relevance 0 Pain Relevance 0.70
Effect of imipramine treatment on the stress-induced increase in CREB-phosphorylation
Regulation (Effect) of Positive_regulation (increase) of CREB associated with stress
2) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.66 Pain Relevance 0.08
The collective in situ and immunoblotting data indicated that CREB and/or activated CREB are regulated by various drugs of abuse within brain regions implicated in addiction.
Regulation (regulated) of Positive_regulation (activated) of CREB in brain associated with addiction
3) Confidence 0.44 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.22 Pain Relevance 0.34
Our results suggest that a nuclear protein kinase, with broad forebrain distribution and the ability to affect gene expression through the activation of CREB, plays a role in anxiety-like behavior and that modulation of CaMKIV activity may prove useful in modifying anxious behavior.
Regulation (affect) of Positive_regulation (activation) of CREB in forebrain associated with anxiety disorder
4) Confidence 0.39 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208947 Disease Relevance 0.85 Pain Relevance 0.14
Rolipram was effective in increasing significantly the levels of activated CREB and of BDNF the striatal spiny neurons, which might account for the beneficial effects observed in this model.
Regulation (effective) of Positive_regulation (increasing) of CREB in neurons
5) Confidence 0.36 Published 2008 Journal Neurobiol. Dis. Section Abstract Doc Link 18424161 Disease Relevance 0.32 Pain Relevance 0.09
AC1 and AC8 are highly expressed in the anterior cingulate cortex (ACC), and contribute to inflammation-induced activation of CREB.
Regulation (contribute) of Positive_regulation (activation) of CREB in cingulate cortex associated with inflammation and anterior cingulate cortex
6) Confidence 0.31 Published 2002 Journal Neuron Section Abstract Doc Link 12441059 Disease Relevance 0.74 Pain Relevance 0.64
Two major pathways responsible for CREB activation are the cAMP signaling pathway and the CaMKIV pathway [22,23] [for review, see [24]].
Regulation (responsible) of Positive_regulation (activation) of CREB
7) Confidence 0.28 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0 Pain Relevance 0.03
Furthermore, we performed an analysis of intracellular signaling mechanisms that could mediate the actions of 3-MT on hTAAR1 expressed in HEK cells. 3-MT caused a rapid and prolonged phosphorylation of Erk2 and CREB only in cells expressing hTAAR1 (Figure 2B,C) thus indicating that a Gs-dependent signaling cascade involving accumulation of cAMP and activation of Erk2 and CREB is likely involved in the action of TAAR1.


Regulation (involved) of Positive_regulation (activation) of CREB
8) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956650 Disease Relevance 0.15 Pain Relevance 0.10
HDL also induce the phosphorylation of p38MAPK, which is implicated in the activation of CREB and subsequent HDL dependent Cox-2 induction and prostacyclin release in endothelial cells (Norata, Callegari, et al 2004).
Regulation (implicated) of Positive_regulation (activation) of CREB in endothelial cells associated with disorder of lipid metabolism
9) Confidence 0.14 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.77 Pain Relevance 0.03

General Comments

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