INT106720

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Context Info
Confidence 0.50
First Reported 2002
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 30
Total Number 35
Disease Relevance 22.05
Pain Relevance 22.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Adcy1) plasma membrane (Adcy1) nucleus (Adcy1)
Anatomy Link Frequency
spinal cord 3
muscle 3
brain 2
ACC neurons 2
neuronal 2
Adcy1 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 276 100.00 Very High Very High Very High
long-term potentiation 474 99.92 Very High Very High Very High
Anterior cingulate cortex 721 99.64 Very High Very High Very High
Spinal cord 193 99.64 Very High Very High Very High
allodynia 443 99.58 Very High Very High Very High
IPN 154 99.48 Very High Very High Very High
opioid receptor 2 99.20 Very High Very High Very High
Hippocampus 139 99.04 Very High Very High Very High
Calcium channel 37 98.52 Very High Very High Very High
Inflammation 303 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 1098 99.88 Very High Very High Very High
Neuropathic Pain 485 99.58 Very High Very High Very High
Inflammatory Pain 154 99.48 Very High Very High Very High
Bordatella Infection 2 99.40 Very High Very High Very High
Nervous System Injury 22 99.26 Very High Very High Very High
Injury 97 98.68 Very High Very High Very High
INFLAMMATION 307 98.28 Very High Very High Very High
Myalgia 435 97.24 Very High Very High Very High
Drug Dependence 19 96.20 Very High Very High Very High
Pain 352 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, we found that both presynaptic and postsynaptic changes after nerve injury were absent in genetic mice lacking calcium-stimulated adenylyl cyclase 1 (AC1).
Positive_regulation (calcium-stimulated) of adenylyl cyclase 1 in nerve associated with nervous system injury
1) Confidence 0.50 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18632948 Disease Relevance 0.84 Pain Relevance 0.71
Finally, we found that both presynaptic and postsynaptic changes after nerve injury were absent in genetic mice lacking calcium-stimulated adenylyl cyclase 1 (AC1).
Positive_regulation (calcium-stimulated) of AC1 in nerve associated with nervous system injury
2) Confidence 0.50 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18632948 Disease Relevance 0.84 Pain Relevance 0.71
These genes were classified as developmental gene changes that resulted from knocking out AC1 and AC8 from birth.
Positive_regulation (knocking) of AC1
3) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954788 Disease Relevance 0.17 Pain Relevance 0
Of the ten AC isoforms in mammals, AC1 and AC8 are the only two that are primarily stimulated by Ca2+/calmodulin [3], [4], [5].
Positive_regulation (stimulated) of AC1
4) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954788 Disease Relevance 0.64 Pain Relevance 0
Two of the adenylyl cyclases, AC1 and AC8, are activated by calcium through the calcium-binding protein calmodulin [3].
Positive_regulation (activated) of AC1
5) Confidence 0.47 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 0.29 Pain Relevance 0.45
The Ca2+/calmodulin-stimulated adenylyl cyclase (AC) isoforms AC1 and AC8, couple NMDA receptor activation to cAMP signaling pathways in neurons and are important for development, learning and memory, drug addiction and persistent pain.
Positive_regulation (activation) of AC1 in neurons associated with pain, drug dependence, addiction, lasting pain and nmda receptor
6) Confidence 0.47 Published 2006 Journal Mol Pain Section Abstract Doc Link PMC1395303 Disease Relevance 0.73 Pain Relevance 0.77
Our results provide genetic, pharmacological and behavioral evidence that adenylyl cyclase isoforms AC1 and AC8 are important for behavioral sensitization after muscle inflammation.
Positive_regulation (important) of AC1 in muscle associated with inflammation
7) Confidence 0.47 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 1.00 Pain Relevance 0.90
Adenylyl cyclase types 1 (AC1) and 8 (AC8), the two major calmodulin-stimulated adenylyl cyclases in the brain, couple NMDA receptor activation to cAMP signaling pathways.
Positive_regulation (activation) of Adenylyl cyclase types 1 in brain associated with nmda receptor
8) Confidence 0.46 Published 2002 Journal Neuron Section Abstract Doc Link 12441059 Disease Relevance 0.53 Pain Relevance 0.32
Adenylyl cyclase types 1 (AC1) and 8 (AC8), the two major calmodulin-stimulated adenylyl cyclases in the brain, couple NMDA receptor activation to cAMP signaling pathways.
Positive_regulation (activation) of AC1 in brain associated with nmda receptor
9) Confidence 0.46 Published 2002 Journal Neuron Section Abstract Doc Link 12441059 Disease Relevance 0.53 Pain Relevance 0.32
To examine whether activation of other adenylyl cyclases rescues the mechanical allodynia phenotype seen in the carrageenan muscle pain model in AC1&8 DKO mice, we injected forskolin (a non-specific adenylyl cyclase activator) into either the ACC, spinal cord or muscle on day 9 when mechanical allodynia was significantly reduced.
Spec (whether) Positive_regulation (activation) of adenylyl cyclase in spinal cord associated with targeted disruption, pain, allodynia, anterior cingulate cortex, myalgia and spinal cord
10) Confidence 0.45 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 1.45 Pain Relevance 1.18
This indicated that activation of adenylyl cyclases in the spinal cord by forskolin produced sufficient cAMP to activate the downstream cascade, rescuing the mechanical allodynia.
Positive_regulation (activation) of adenylyl cyclase in spinal cord associated with allodynia and spinal cord
11) Confidence 0.45 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 0.95 Pain Relevance 1.02
Two of the adenylyl cyclases, AC1 and AC8, are activated by calcium through the calcium-binding protein calmodulin [3].
Positive_regulation (activated) of adenylyl cyclase
12) Confidence 0.45 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 0.29 Pain Relevance 0.45
Activation of adenylyl cyclases in the spinal cord, but not in peripheral tissue, rescued mechanical allodynia
Positive_regulation (Activation) of adenylyl cyclase in spinal cord associated with allodynia and spinal cord
13) Confidence 0.45 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 1.15 Pain Relevance 1.24
The data suggests that cAMP produced by forskolin through the activation of other adenylyl cyclases in AC1&8 DKO can rescue mechanical allodynia.
Positive_regulation (activation) of adenylyl cyclase associated with targeted disruption and allodynia
14) Confidence 0.45 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 1.19 Pain Relevance 1.24
To test whether there is similar activation of adenylyl cyclases at the peripheral nerve endings in the muscle, we injected forskolin into the gastrocnemius muscle, where muscle injections were originally given.
Spec (whether) Positive_regulation (activation) of adenylyl cyclase in muscle
15) Confidence 0.45 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 0.90 Pain Relevance 0.95
This did not produce any significant effect on mechanical allodynia (Fig. 7B) (forskolin injection, n = 4 mice; vehicle injection,n = 3 mice; p > 0.05) indicating that peripheral activation of adenylyl cyclases, either within the nerve endings or in the non-neuronal cells, to increase cAMP has no effect in reducing the threshold of mechanical allodynia.


Positive_regulation (activation) of adenylyl cyclase in neuronal associated with allodynia
16) Confidence 0.45 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 0.85 Pain Relevance 0.92
Activation of other adenylyl cyclases in these KO mice by microinjection of forskolin into the ACC or spinal cord, but not into the peripheral tissue, rescued the behavioral nociceptive responses.
Positive_regulation (Activation) of adenylyl cyclase in ACC associated with nociception, targeted disruption, anterior cingulate cortex and spinal cord
17) Confidence 0.45 Published 2006 Journal Mol Pain Section Abstract Doc Link PMC1395303 Disease Relevance 1.68 Pain Relevance 1.16
Activation of non-Ca2+/calmodulin-stimulated adenylyl cyclases in the ACC 'rescued' behavioral sensitization
Positive_regulation (Activation) of adenylyl cyclase associated with anterior cingulate cortex
18) Confidence 0.45 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 1.51 Pain Relevance 1.16
While the reason for this is not yet known, we hypothesize that direct activation of non-Ca2+/calmodulin-stimulated adenylyl cyclases may initiate cellular changes in neuronal and/or non-neuronal cells ultimately triggering downstream pathways following the cAMP step in neurons.
Positive_regulation (activation) of adenylyl cyclase in neuronal
19) Confidence 0.45 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 0.47 Pain Relevance 0.46
Among them, we found that activation of AC1 and CaMKIV is essential for the induction of LTP in the ACC [11,15].
Positive_regulation (activation) of AC1 associated with long-term potentiation and anterior cingulate cortex
20) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0 Pain Relevance 0.66

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