INT106721

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.32
Pain Relevance 4.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Adcy1) plasma membrane (Adcy1) nucleus (Adcy1)
Anatomy Link Frequency
neuronal 1
cingulate cortex 1
Adcy1 (Mus musculus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 241 100.00 Very High Very High Very High
Inflammation 16 99.84 Very High Very High Very High
antagonist 22 99.80 Very High Very High Very High
long-term potentiation 235 98.44 Very High Very High Very High
nMDA receptor 116 97.92 Very High Very High Very High
Inflammatory stimuli 1 96.48 Very High Very High Very High
Spinal cord 7 95.84 Very High Very High Very High
Hippocampus 10 94.40 High High
Glutamate 24 93.88 High High
Acute pain 2 93.20 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 17 99.84 Very High Very High Very High
Targeted Disruption 66 99.72 Very High Very High Very High
Pain 104 93.20 High High
Neuropathic Pain 17 91.84 High High
Injury 34 88.64 High High
Drug Dependence 3 87.64 High High
Brain Disease 3 81.16 Quite High
Amnesia 2 78.96 Quite High
Cognitive Disorder 2 76.80 Quite High
Convulsion 1 75.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AC1 and AC8 are highly expressed in the anterior cingulate cortex (ACC), and contribute to inflammation-induced activation of CREB.
Regulation (contribute) of AC1 in cingulate cortex associated with inflammation and anterior cingulate cortex
1) Confidence 0.45 Published 2002 Journal Neuron Section Abstract Doc Link 12441059 Disease Relevance 0.75 Pain Relevance 0.64
Both AC1 and CaMKIV contribute to the regulation of FMRP by group I mGluRs probably through cAMP response element-binding protein activation.
Regulation (regulation) of AC1
2) Confidence 0.42 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18434517 Disease Relevance 0.37 Pain Relevance 0.37
Alternatively, in the case that side effects in humans are found with NR2B antagonists, one may target on downstream proteins such as AC1.
Spec (may) Regulation (target) of AC1 associated with antagonist
3) Confidence 0.34 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 1.00 Pain Relevance 0.83
Genetic evidence for adenylyl cyclase 1 as a target for preventing neuronal excitotoxicity mediated by N-methyl-D-aspartate receptors.
Regulation (target) of cyclase 1 in neuronal associated with nmda receptor
4) Confidence 0.24 Published 2007 Journal J. Biol. Chem. Section Title Doc Link 17121841 Disease Relevance 0.21 Pain Relevance 0.40
As the downstream target of AC1, cAMP-dependent protein kinase (PKA) may activate MEK and ERK/MAPK.
Regulation (target) of AC1
5) Confidence 0.18 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0 Pain Relevance 0.62
As the downstream target of AC1, cyclic-AMP (cAMP)-dependent protein kinase (PKA) is known to activate extracellular signal-regulated kinase (ERK) and ERK/MAPK (mitogen-activated protein kinase).
Regulation (target) of AC1
6) Confidence 0.16 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0 Pain Relevance 0.53
As compared with AC8, AC1 is more sensitive to calcium increase.
Regulation (sensitive) of AC1
7) Confidence 0.09 Published 2007 Journal Mol Pain Section Body Doc Link PMC1904186 Disease Relevance 0 Pain Relevance 0.78

General Comments

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