INT106733

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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.76
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CDK2) nucleoplasm (CDK2) cytoplasm (CDK2)
cytosol (CDK2) mitosis (CDK2) nucleus (CDK2)
Anatomy Link Frequency
keratinocyte 1
CDK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
peptic ulcer disease 1 92.28 High High
Inflammation 18 88.56 High High
Spinal cord 12 58.36 Quite High
Bile 3 50.60 Quite High
withdrawal 10 50.00 Quite Low
agonist 17 12.00 Low Low
Kinase C 13 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 68 99.36 Very High Very High Very High
Gastritis 3 98.26 Very High Very High Very High
Hypoxia 35 97.36 Very High Very High Very High
Acantholysis 65 96.68 Very High Very High Very High
Apoptosis 95 96.64 Very High Very High Very High
Bullous Skin Disease 304 96.04 Very High Very High Very High
Ulcers 1 92.28 High High
Disease 24 91.76 High High
Stomach Cancer 1 91.28 High High
Death 12 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Helicobacter pylori releases a factor(s) inhibiting cell cycle progression of human gastric cell lines by affecting cyclin E/cdk2 kinase activity and Rb protein phosphorylation through enhanced p27(KIP1) protein expression.
Regulation (affecting) of cdk2 associated with gastritis
1) Confidence 0.44 Published 2002 Journal Exp. Cell Res. Section Title Doc Link 12441136 Disease Relevance 0.64 Pain Relevance 0.09
In addition, alterations in CDK1, CDK2, CDK4, cyclin D1 and cyclin E have been reported following exposure to PP [67,68,71].
Regulation (alterations) of CDK2
2) Confidence 0.26 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 0.39 Pain Relevance 0.06
Cyclin E over expression is a common feature in cancer [22], suggesting that cyclin E/CDK2 deregulation contributes to tumorigenesis.
Regulation (deregulation) of CDK2 associated with cancer
3) Confidence 0.24 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.93 Pain Relevance 0.04
Similar results showing that SHP1 downregulation effected p27Kip1 expression and Cdk2-cyclin E complex formation have been reported [43].
Regulation (effected) of Cdk2
4) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.07 Pain Relevance 0
Similar to c-Myc, cyclin-dependent kinase 2 (cdk2), another kinase involved in the regulation of cell cycle progression, seems to be involved in keratinocyte proliferation and acantholysis in pemphigus (Lanza et al. 2008).
Regulation (regulation) of cdk2 in keratinocyte associated with acantholysis and bullous skin disease
5) Confidence 0.12 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.49 Pain Relevance 0
S1, in an experimental hypoxic and DHP-d-induced ROS scavenging environment, de-ATSC grew continuously for more than 3 months (>20 passages) and their cell cycle controlling factors such as CDK1, CDK2, and RUNX3 expression was prominently increased along with active growth activity compared to in the case of hypoxic or DHP-d single treatment (Fig.
Regulation (controlling) of CDK2 associated with hypoxia
6) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 1.24 Pain Relevance 0.03

General Comments

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