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Context Info
Confidence 0.74
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.65
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MED1) small molecule metabolic process (MED1) cell morphogenesis (MED1)
nucleolus (MED1) nucleus (MED1) DNA binding (MED1)
Anatomy Link Frequency
fibroblasts 1
MED1 (Homo sapiens)
Pain Link Frequency Relevance Heat
peptic ulcer disease 3 94.16 High High
member 8 1 69.88 Quite High
Disease Link Frequency Relevance Heat
Gastritis 9 98.08 Very High Very High Very High
Ulcers 3 94.16 High High
Disease 3 93.64 High High
Alagille Syndrome 6 93.60 High High
Stomach Cancer 3 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MED1 phosphorylation was sensitive to activators and inhibitors of the ERK1/2 signaling and MED1 siRNA reduced 1,25(OH)(2)D(3)-regulated human CYP24 promoter activity.
Phosphorylation (phosphorylation) of MED1
1) Confidence 0.74 Published 2009 Journal J. Cell. Physiol. Section Abstract Doc Link 19097033 Disease Relevance 0 Pain Relevance 0.07
The cell cycle inhibition occurred concomitantly with an increase in p27(KIP1) protein levels, a reduction in Rb protein phosphorylation on serine residues 807-811, and a significant decrease in cyclin E-associated cdk2 activity.
Phosphorylation (phosphorylation) of Rb protein
2) Confidence 0.03 Published 2002 Journal Exp. Cell Res. Section Abstract Doc Link 12441136 Disease Relevance 0.56 Pain Relevance 0.06
In normal human fibroblasts, G1-phase cell accumulation was concomitant with the reduction in Rb protein phosphorylation; that, however, appeared to be dependent on p21(WAF1/CIP1) rather than on p27(KIP1) protein.
Phosphorylation (phosphorylation) of Rb protein in fibroblasts
3) Confidence 0.03 Published 2002 Journal Exp. Cell Res. Section Abstract Doc Link 12441136 Disease Relevance 0.39 Pain Relevance 0.05
Helicobacter pylori releases a factor(s) inhibiting cell cycle progression of human gastric cell lines by affecting cyclin E/cdk2 kinase activity and Rb protein phosphorylation through enhanced p27(KIP1) protein expression.
Phosphorylation (phosphorylation) of Rb protein associated with gastritis
4) Confidence 0.03 Published 2002 Journal Exp. Cell Res. Section Title Doc Link 12441136 Disease Relevance 0.70 Pain Relevance 0.09

General Comments

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