INT106735

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Context Info
Confidence 0.79
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.03
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CDK2) nucleoplasm (CDK2) cytoplasm (CDK2)
cytosol (CDK2) mitosis (CDK2) nucleus (CDK2)
CDK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 876 99.42 Very High Very High Very High
peptic ulcer disease 1 94.16 High High
cerebral cortex 6 74.80 Quite High
cINOD 4 66.08 Quite High
antagonist 44 5.00 Very Low Very Low Very Low
Central nervous system 31 5.00 Very Low Very Low Very Low
local anesthetic 14 5.00 Very Low Very Low Very Low
Opioid 13 5.00 Very Low Very Low Very Low
Spinal cord 12 5.00 Very Low Very Low Very Low
Inflammation 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 80 99.34 Very High Very High Very High
Gastritis 3 98.08 Very High Very High Very High
Glioma 53 97.28 Very High Very High Very High
Hyperlipidemia 1 95.36 Very High Very High Very High
Ulcers 4 94.16 High High
Disease 29 93.64 High High
Stomach Cancer 4 93.16 High High
Stress 90 92.40 High High
Hypoxia 42 91.32 High High
Cancer 220 82.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Helicobacter pylori releases a factor(s) inhibiting cell cycle progression of human gastric cell lines by affecting cyclin E/cdk2 kinase activity and Rb protein phosphorylation through enhanced p27(KIP1) protein expression.
Phosphorylation (phosphorylation) of cdk2 associated with gastritis
1) Confidence 0.79 Published 2002 Journal Exp. Cell Res. Section Title Doc Link 12441136 Disease Relevance 0.70 Pain Relevance 0.09
However, the level of phospho-Rb (Ser795), which is specifically phosphorylated by Cdk2/4 in the G1 phase [12], was decreased at 15, 18, and 21 hours following exposure to 10-6 M OGF, and reached statistical significance at 21 hours (p < 0.01) (Figs. 2A, B).
Phosphorylation (phosphorylated) of Cdk2 associated with retinoblastoma
2) Confidence 0.66 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.86 Pain Relevance 0
Treatment with lovastatin or celecoxib decreased the levels of cyclin D1, CDK2, pRb and E2F1, while the combination treatment showed more pronounced suppression.
Phosphorylation (levels) of CDK2
3) Confidence 0.60 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19787257 Disease Relevance 0.33 Pain Relevance 0.07
Western blotting showed that cocaine significantly decreased the phosphorylated forms of CDK2 and pRb (Figure 5A), indicating that cocaine-induced down-regulation of cyclin A results in a hypoactive state of the downstream cell cycle signaling pathway.


Phosphorylation (phosphorylated) of CDK2 associated with cocaine
4) Confidence 0.52 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.18 Pain Relevance 0.41
-tubulin (Sigma-Aldrich), phospho-CDK2 (Thr-160), phospho-eIF2?
Phosphorylation (phospho) of CDK2
5) Confidence 0.51 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.07 Pain Relevance 0.04
Activated CDK2 phosphorylates the downstream molecule pRb, which in turn promotes the expression of genes required for progression from G1 to S.
Phosphorylation (phosphorylates) of CDK2
6) Confidence 0.51 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.14 Pain Relevance 0.41
In early and late G1 phase, p-Rb is hyperphosphorylated by D-type Cdks and Cdk2-cyclin E, respectively [26], [47], [48].
Phosphorylation (hyperphosphorylated) of Cdk2
7) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.09 Pain Relevance 0
However, AKT-independent and Cdk2-dependent phosphorylation affected FOXO1 nuclear export to different extents in U87 and U251 glioma cells [22].
Phosphorylation (phosphorylation) of Cdk2 associated with glioma
8) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.10 Pain Relevance 0
It has been observed that proteasome inhibitors partially prevent lovastatin-induced E2F-1 degradation, suggesting that lovastatin modulates E2F-1 proteasomal degradation, which may be a critical regulatory mechanism of lovastatin-induced effects [338], and that mevastatin inhibits cdk2 activity in PC3 cells through Thr-160 phosphorylation inhibition of cdk2 [339].
Phosphorylation (phosphorylation) of cdk2
9) Confidence 0.28 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.80 Pain Relevance 0
UL97 has an amino acid substitution at the Cdk site (Thr 160 of Cdk2) of phosphorylation by Cdk activating kinase (CAK), and is active under conditions of CAK inhibition.
Phosphorylation (phosphorylation) of Cdk2
10) Confidence 0.27 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 0.23 Pain Relevance 0
When treated with JAKinase inhibitors, STAT3 phosphorylation and associated proliferation factors involving cell growth and CDK1, CDK2, Rex1, Nanog, and RUNX3 expression was decreased profoundly (Figure 3A and 3B, 3C).
Phosphorylation (phosphorylation) of CDK2
11) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.54 Pain Relevance 0

General Comments

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