INT106745

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Context Info
Confidence 0.81
First Reported 2002
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 65
Total Number 67
Disease Relevance 66.44
Pain Relevance 15.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP) extracellular region (CRP)
Anatomy Link Frequency
blood 3
myocardium 2
joint 2
plaque 2
plasma 1
CRP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 820 100.00 Very High Very High Very High
rheumatoid arthritis 646 100.00 Very High Very High Very High
cytokine 408 100.00 Very High Very High Very High
chemokine 35 100.00 Very High Very High Very High
Inflammatory marker 96 99.96 Very High Very High Very High
Arthritis 180 99.70 Very High Very High Very High
Inflammatory response 66 99.66 Very High Very High Very High
spinal inflammation 84 99.40 Very High Very High Very High
spastic colon 25 99.32 Very High Very High Very High
Leflunomide 64 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 974 100.00 Very High Very High Very High
Disease 686 100.00 Very High Very High Very High
Rheumatoid Arthritis 653 100.00 Very High Very High Very High
Cardiovascular Disease 237 100.00 Very High Very High Very High
Coronary Artery Disease 229 100.00 Very High Very High Very High
Obesity 218 100.00 Very High Very High Very High
Alzheimer's Dementia 53 100.00 Very High Very High Very High
Cancer 119 99.92 Very High Very High Very High
Fever 22 99.80 Very High Very High Very High
Respiratory Syncytial Virus 50 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coronary atherectomy probes from 90 primary stenoses were immunohistochemically analyzed with regard to the presence and the localization of CRP.
Spec (analyzed) Localization (localization) of CRP associated with pathologic constriction
1) Confidence 0.81 Published 2002 Journal Z Kardiol Section Abstract Doc Link 12442194 Disease Relevance 1.25 Pain Relevance 0.31
CRP was focally localized in a maximum of 69% of all plaque cells, the most in macrophages/foam cells, infrequently in smooth muscle cells.
Localization (localized) of CRP in macrophages
2) Confidence 0.81 Published 2002 Journal Z Kardiol Section Abstract Doc Link 12442194 Disease Relevance 1.38 Pain Relevance 0.35
CRP secretion is increased in response to a complex network of cytokines, especially IL-6 and either IL-1 or tumor necrosis factor (TNF-?)
Localization (secretion) of CRP associated with necrosis, cancer and cytokine
3) Confidence 0.80 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2989710 Disease Relevance 1.36 Pain Relevance 0.21
Other inflammatory markers include cytokines such as interleukin-6 (IL-6), which can regulate CRP release [11,12], and tumor necrosis factor alpha (TNF-alpha), adhesion molecules such as VCAM-1, ICAM-1 and E-selectin [13] and eicosanoids like prostaglandin E2 (PGE2) [14,15].
Localization (release) of CRP associated with necrosis, cancer, inflammatory marker, adhesions and cytokine
4) Confidence 0.77 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2837611 Disease Relevance 2.65 Pain Relevance 0.42
Local CRP was predictive of features characteristic of OB (R = 0.456–0.879, P < .05?
Localization (Local) of CRP associated with respiratory syncytial virus
5) Confidence 0.74 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2686807 Disease Relevance 0.50 Pain Relevance 0.04
During OB development, CRP is localized in inflammatory cells, myofibroblasts and endothelial cells probably as a part of the local inflammatory response.


1.

Localization (localized) of CRP in endothelial cells associated with inflammatory response, inflammation and respiratory syncytial virus
6) Confidence 0.74 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2686807 Disease Relevance 0.67 Pain Relevance 0.14
To focus on modulation of inflammation by diclofenac, and not acute phase response, only markers that did not show significant correlation to CRP response (across all subjects) were selected.
Localization (response) of CRP associated with acute-phase reaction, inflammation and diclofenac
7) Confidence 0.72 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2837611 Disease Relevance 0.56 Pain Relevance 0.51
Furthermore, the distribution of CRP and the relationship between CRP and obesity vary according to race and gender, with certain minority groups having greater risks associated with CRP [24–26].
Localization (distribution) of CRP associated with obesity
8) Confidence 0.70 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872322 Disease Relevance 1.01 Pain Relevance 0.28
On the other hand, local CRP synthesis and secretion by smooth muscle cells, including those of the human coronary artery, have been suggested to play an important role as well [22].
Localization (secretion) of CRP in coronary artery
9) Confidence 0.70 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2975076 Disease Relevance 1.32 Pain Relevance 0.11
The partial correlation between MMP-9 and CRP (adjusting for age and sex) was r?
Localization (correlation) of CRP
10) Confidence 0.70 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258002 Disease Relevance 0.56 Pain Relevance 0.21
Such mechanism is supported by the observations of co-localization of CRP and activated complement in infarct-related myocardium.
Localization (-) of CRP in myocardium
11) Confidence 0.67 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.08 Pain Relevance 0.33
RA patients for DAS28, VAS, ESR, CRP, disease duration, HLA genotype, and radiological assessment of hand.
Localization (assessment) of CRP associated with rheumatoid arthritis and disease
12) Confidence 0.67 Published 2008 Journal Rheumatol Int Section Abstract Doc Link PMC2493537 Disease Relevance 1.31 Pain Relevance 0.46
Serum MMP-3 decreased significantly (P=0.04); significant decreases were also noted for the ESR, CRP, and BASDAI.
Localization (noted) of CRP
13) Confidence 0.67 Published 2008 Journal Joint Bone Spine Section Body Doc Link 18674944 Disease Relevance 0 Pain Relevance 0
Also in support of the biphasic recovery of CrP, Bogdanis et al. [5] found that following a 30 seconds sprint on a cycle ergometer CrP was depleted to 19.5 ± 1.2% of resting levels immediately following the cessation of exercise.
Localization (depleted) of CrP
14) Confidence 0.66 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3005844 Disease Relevance 0 Pain Relevance 0
Moreover, using high-sensitivity assays for CRP (hs-CRP), several studies have shown elevated CRP levels in obesity, since adiposity resembles a low grade systemic inflammatory state and hs-CRP is released by adipose tissue [21, 22].
Localization (released) of hs-CRP in adipose tissue associated with inflammation and obesity
15) Confidence 0.65 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2896837 Disease Relevance 1.54 Pain Relevance 0.15
Interleukin-6 (IL-6), an inflammatory cytokine and major inducer of the secretion of CRP, is also associated with CVD [15].
Localization (secretion) of CRP associated with inflammation, cardiovascular disease and cytokine
16) Confidence 0.64 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148106 Disease Relevance 1.62 Pain Relevance 0.50
Serum hs-CRP
Localization (Serum) of hs-CRP
17) Confidence 0.64 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804298 Disease Relevance 0.77 Pain Relevance 0
We used logarithmic transformation for CRP and triglycerides.
Localization (transformation) of CRP
18) Confidence 0.61 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2574036 Disease Relevance 0.45 Pain Relevance 0
For these analyses, natural log-transformations were performed to approximate normality of CRP, IL-6, adiponectin, resistin, PAI-1 and RBP4, as they were not normally distributed.
Localization (normality) of CRP
19) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148106 Disease Relevance 1.18 Pain Relevance 0.19
Such mechanism is supported by the observations of co-localization of CRP and activated complement in infarct-related myocardium.
Localization (localization) of CRP in myocardium
20) Confidence 0.59 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.08 Pain Relevance 0.33

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