INT106749

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Context Info
Confidence 0.34
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.12
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleolus (Casp3) nucleus (Casp3) intracellular (Casp3)
Anatomy Link Frequency
neurons 2
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 9 100.00 Very High Very High Very High
narcan 3 99.84 Very High Very High Very High
Glutamate 292 98.32 Very High Very High Very High
ischemia 29 96.96 Very High Very High Very High
antagonist 5 88.72 High High
Nerve growth factor 1 86.56 High High
Opioid 1 82.48 Quite High
cerebral cortex 1 81.76 Quite High
Endogenous opioid 1 81.40 Quite High
Hippocampus 2 80.40 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 213 99.92 Very High Very High Very High
Death 177 98.72 Very High Very High Very High
Hypoxia 29 98.28 Very High Very High Very High
Injury 28 97.60 Very High Very High Very High
Cv Unclassified Under Development 25 96.96 Very High Very High Very High
Neurodegenerative Disease 19 95.24 Very High Very High Very High
Cancer 13 94.32 High High
Disease 17 91.64 High High
Hypertension 3 71.60 Quite High
Stress 21 61.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glutamate-induced apoptosis in primary cortical neurons is inhibited by equine estrogens via down-regulation of caspase-3 and prevention of mitochondrial cytochrome c release

Background

Negative_regulation (down) of Negative_regulation (regulation) of caspase-3 in neurons associated with glutamate and apoptosis
1) Confidence 0.34 Published 2005 Journal BMC Neurosci Section Title Doc Link PMC555946 Disease Relevance 0.93 Pain Relevance 0.21
Caspase inhibitors, including inhibitors of caspase-3, may prolong the therapeutic window after hypoxic-ischemic injury (7, 27, 28).
Negative_regulation (inhibitors) of Negative_regulation (inhibitors) of caspase-3 associated with hypoxia and injury
2) Confidence 0.21 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693548 Disease Relevance 1.72 Pain Relevance 0.12
In contrast, caspase inhibitors, either the specific caspase-3 inhibitor z-DEVD (Figure 3E) or a pancaspase inhibitor z-VAD (Figure 3F) at a concentration of 100 ?
Negative_regulation (inhibitors) of Negative_regulation (inhibitor) of caspase-3
3) Confidence 0.20 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1526740 Disease Relevance 0.68 Pain Relevance 0.28
PES per se did not influence the natural place preference in rats, and (5). the inhibition of cocaine CPP induced by 100 Hz PES could be reversed by naloxone pre-treatment at 10 mg/kg, but not at lower doses.
Negative_regulation (reversed) of Negative_regulation (inhibition) of CPP associated with narcan and cocaine
4) Confidence 0.13 Published 2002 Journal Brain Res. Section Abstract Doc Link 12443988 Disease Relevance 0 Pain Relevance 0.63
Another interesting observation during this study was that at 21 days, a decrease in Ki-67 and Caspase-3 was predictive of favorable response (p = 0.01 for both).
Negative_regulation (predictive) of Negative_regulation (decrease) of Caspase-3
5) Confidence 0.08 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2669088 Disease Relevance 0.67 Pain Relevance 0
that rosiglitazone treatment decreases caspase-3 levels leading to reduced
Negative_regulation (reduced) of Negative_regulation (decreases) of caspase-3
6) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2293414 Disease Relevance 1.13 Pain Relevance 0.24

General Comments

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