INT10675

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Context Info
Confidence 0.67
First Reported 1981
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 28
Total Number 42
Disease Relevance 19.74
Pain Relevance 6.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (DBI) transport (DBI)
Anatomy Link Frequency
plasma 4
cerebrospinal fluid 2
bridges 2
oviduct 2
pituitary gland 2
DBI (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 30 100.00 Very High Very High Very High
Clonidine 4 99.78 Very High Very High Very High
headache 42 99.70 Very High Very High Very High
Analgesic 22 99.60 Very High Very High Very High
Opioid 4 99.38 Very High Very High Very High
Serotonin 4 99.20 Very High Very High Very High
Central grey 5 98.12 Very High Very High Very High
electroacupuncture 5 94.64 High High
Pain 18 93.68 High High
opiate 5 93.28 High High
Disease Link Frequency Relevance Heat
Ectopic Pregnancy 1425 100.00 Very High Very High Very High
Reprotox - General 1 210 100.00 Very High Very High Very High
Emergencies 60 100.00 Very High Very High Very High
Abdominal Pain 30 100.00 Very High Very High Very High
Headache 18 99.70 Very High Very High Very High
Neurological Disease 1 99.44 Very High Very High Very High
Tubal Pregnancy 150 98.68 Very High Very High Very High
Obesity 27 98.20 Very High Very High Very High
Urological Neuroanatomy 5 98.12 Very High Very High Very High
Threatened Abortion 15 97.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Low systemic levels of DI and EP are produced from DI-EP.
Gene_expression (produced) of DI-EP
1) Confidence 0.67 Published 2008 Journal Curr Med Res Opin Section Body Doc Link 18814824 Disease Relevance 0.06 Pain Relevance 0
DESIGN: We produced monoclonal antibodies to beta-EP and beta-LPH for the development of two-site immunoradiometric assays (IRMAs) which specifically quantitate beta-EP and beta-LPH.
Gene_expression (produced) of beta-EP
2) Confidence 0.44 Published 1993 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 8287571 Disease Relevance 0 Pain Relevance 0
Ac-beta-EP was detectable in all but 5 normal subjects.
Gene_expression (detectable) of beta-EP
3) Confidence 0.38 Published 1992 Journal Brain Res. Section Abstract Doc Link 1511339 Disease Relevance 0.26 Pain Relevance 0.38
Ac beta-EP is present in human fetal and adult pituitary gland and cross-reacts in all available beta-EP assays.
Gene_expression (present) of beta-EP in pituitary gland
4) Confidence 0.38 Published 1992 Journal Brain Res. Section Abstract Doc Link 1511339 Disease Relevance 0.14 Pain Relevance 0.28
Alpha-N-acetyl-beta-endorphin (Ac-beta-EP) is a post-translational product of beta-endorphin (beta-EP) with no analgesic properties.
Gene_expression (product) of beta-EP associated with analgesic
5) Confidence 0.38 Published 1992 Journal Brain Res. Section Abstract Doc Link 1511339 Disease Relevance 0.13 Pain Relevance 0.27
Alpha-N-acetyl-beta-endorphin (Ac-beta-EP) is a post-translational product of beta-endorphin (beta-EP) with no analgesic properties.
Gene_expression (product) of beta-EP associated with analgesic
6) Confidence 0.33 Published 1992 Journal Brain Res. Section Abstract Doc Link 1511339 Disease Relevance 0.08 Pain Relevance 0.21
In headache sufferers, Ac-beta-EP levels were higher than normal, whereas beta-EP concentrations were lower.
Gene_expression (levels) of beta-EP associated with headache
7) Confidence 0.33 Published 1992 Journal Brain Res. Section Abstract Doc Link 1511339 Disease Relevance 0.30 Pain Relevance 0.33
In headache sufferers, Ac-beta-EP levels were always detectable and their mean value was significantly higher than that of healthy subjects (11.6 +/- 11.8 vs 3.9 +/- 3.6 fmol/ml; P less than 0.01).
Gene_expression (detectable) of beta-EP associated with headache
8) Confidence 0.33 Published 1992 Journal Brain Res. Section Abstract Doc Link 1511339 Disease Relevance 0.27 Pain Relevance 0.39
Two antisera (HO and UA) were raised in rabbits against human beta-EP, each of which recognized human, porcine, bovine, ovine, camel and rat beta-EP, the only difference being that HO recognized rabbit beta-EP while UA did not.
Gene_expression (raised) of beta-EP
9) Confidence 0.30 Published 1983 Journal Int. J. Neurosci. Section Abstract Doc Link 6305863 Disease Relevance 0.35 Pain Relevance 0.75
No presence of beta-LPH, beta-EP and ACTH was confirmed, while gamma-EP, alpha-MSH and des-alpha-MSH were detected for the first time in follicular fluid.
Gene_expression (detected) of gamma-EP
10) Confidence 0.29 Published 1988 Journal Peptides Section Abstract Doc Link 2854246 Disease Relevance 0 Pain Relevance 0.06
The prostaglandin (PG) EP(4) receptor subtype is expressed by peripheral sensory neurons.
Gene_expression (expressed) of EP in sensory neurons
11) Confidence 0.27 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17495127 Disease Relevance 0.09 Pain Relevance 0.29
Two analogs of human beta-endorphin (beta-EP) which contain cystine bridges, [Cys15-Cys26,Phe27,Gly31]-beta-EP (I) and [Cys16-Cys26,Phe27,Gly31]-beta-EP (II), were synthesized by the solid-phase method.
Gene_expression (synthesized) of beta-EP in bridges
12) Confidence 0.25 Published 1985 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 2993181 Disease Relevance 0 Pain Relevance 0.16
Acute administration of L5-OH-triptophan, the physiologic precursor of serotonin (SE), induced a significant rise in plasma beta-EP and beta-LPH levels both when injected iv (20 and 40 mg) (four normal men) and when administered orally (200 and 400 mg) (seven normal men) (P less than 0.01 vs. placebo).
Gene_expression (levels) of beta-EP in plasma associated with serotonin
13) Confidence 0.25 Published 1984 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6092410 Disease Relevance 0 Pain Relevance 0.24
CJ-023,423 is highly selective for the human EP(4) receptor over other human prostanoid receptor subtypes.
Gene_expression (selective) of EP
14) Confidence 0.23 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17495127 Disease Relevance 0.28 Pain Relevance 0.48
We assessed plasma and cerebrospinal fluid (CSF) levels of SRIH, beta-endorphin (beta-EP), CRH, NPY and GHRH in a group of massively obese patients and in normal weight subjects.
Gene_expression (levels) of beta-EP in cerebrospinal fluid associated with obesity
15) Confidence 0.21 Published 1995 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 7719386 Disease Relevance 0.33 Pain Relevance 0
Plasma levels of SRIH, beta-EP, NPY and GHRH did not differ significantly in the two groups of subjects; plasma CRH was undetectable.
Gene_expression (levels) of beta-EP in plasma
16) Confidence 0.21 Published 1995 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 7719386 Disease Relevance 0.64 Pain Relevance 0.07
Two analogs of human beta-endorphin (beta-EP) which contain cystine bridges, [Cys15-Cys26,Phe27,Gly31]-beta-EP (I) and [Cys16-Cys26,Phe27,Gly31]-beta-EP (II), were synthesized by the solid-phase method.
Gene_expression (synthesized) of beta-EP in bridges
17) Confidence 0.17 Published 1985 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 2993181 Disease Relevance 0 Pain Relevance 0.16
In an attempt to characterize factors affecting production and secretion of VEGF in EP, expression of VEGF mRNA and the VEGF receptors KDR and flt-1 were measured in implanted and non-implanted sites of the oviduct in women with EP41.
Gene_expression (expression) of EP in oviduct associated with ectopic pregnancy
18) Confidence 0.13 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.88 Pain Relevance 0.05
In an attempt to characterize factors affecting production and secretion of VEGF in EP, expression of VEGF mRNA and the VEGF receptors KDR and flt-1 were measured in implanted and non-implanted sites of the oviduct in women with EP41.
Gene_expression (receptors) of EP in oviduct associated with ectopic pregnancy
19) Confidence 0.13 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.89 Pain Relevance 0.05
ROC curves demonstrated significant discriminatory capability of increased CK for EP diagnosis, suggesting that CK concentrations could be used to predict EP.42
Gene_expression (diagnosis) of EP associated with ectopic pregnancy
20) Confidence 0.13 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.15 Pain Relevance 0.03

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